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  #당뇨병#골다공증#뇌하수체 및 부신 질환#기타 내분비 질환

학력

· 경북대학교 의과대학 1982년 졸업
· 석사 - 1983년 경북대학교 대학원
· 박사 - 1988년 경북대학교 대학원

경력

· 1988 ~ 89 미국 하바드의대 조슬린 당뇨센터 연구원
· 1994 ~ 95 미국 하바드의대 조슬린 당뇨센터 연구원
· 1995 ~ 98 계명의대 동산의료원 내분비내과 내분비내과 분과장 부교수
· 1998 ~ 05 계명의대 동산의료원 내분비내과 내분비내과 분과장 교수
· 2005. 4. 1 ~ 현재 경북대학교 의과대학 내분비 내과학교수
· 2005. 4. 20 ~ 현재 경북대학병원 내분비내과 분과장
· 2005 ~ 현재 경북의대 내분비내과 내분비내과분과장 교수

논문

[2017] Low-Dose Persistent Organic Pollutants Impair Insulin Secretory Function of Pancreatic Beta-Cells: Human and in Vitro Evidence. (Diabetes)

[2017] The relationship between muscle mitochondrial nutritional overloading and insulin resistance (Yeungnam University Journal of Medicine)

[2017] Protective effects of 1,2,3-triazole derivative KPR-A020 against cisplatin-induced ototoxicity in murine cochlear cultures (INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY)

[2017] Pyruvate dehydrogenase kinase 4 deficiency attenuates cisplatin-induced acute kidney injury (KIDNEY INTERNATIONAL)

[2017] Gemigliptin ameliorates Western-diet-induced metabolic syndrome in mice (CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY)

[2017] A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells (CELL REPORTS)

[2017] Protective Effects of Gemigliptin, a Dipeptidyl Peptidase-4 Inhibitor, against Cisplatin-Induced Nephrotoxicity in Mice (MEDIATORS OF INFLAMMATION)

[2016] Role of Mitochondria-Associated Endoplasmic Reticulum Membrane in Inflammation-Mediated Metabolic Diseases (MEDIATORS OF INFLAMMATION)

[2016] Fyn deficiency attenuates renal fibrosis by inhibition of phospho-STAT3 (KIDNEY INTERNATIONAL)

[2016] Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis.
(Diabetes)

[2016] Mechanisms of Vascular Calcification: The Pivotal Role of Pyruvate Dehydrogenase Kinase 4 (Endocrinology and Metabolism)

[2015] Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation (Scientific Reports)

[2015] Estrogen-Related Receptor gamma Plays a Key Role in Vascular Calcification Through the Upregulation of BMP2 Expression (ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY)

[2015] Dipeptidyl peptidase-4 inhibition by gemigliptin prevents abnormal vascular remodeling via NF-E2-related factor 2 activation (VASCULAR PHARMACOLOGY)

[2015] Colorectal cancer-derived tumor spheroids retain the characteristics of original tumors (CANCER LETTERS)

[2015] Non-receptor tyrosine kinase inhibitors enhances beta-cell survival by suppressing the PKC delta signal transduction pathway in streptozotocin - induced
beta-cell apoptosis (CELLULAR SIGNALLING)

[2015] Regulation of systemic energy homeostasis by serotonin in adipose tissues (NATURE COMMUNICATIONS)

[2015] Retinoic Acid-Related Orphan Receptor Alpha Reprograms Glucose Metabolism in Glutamine-Deficient Hepatoma Cells (HEPATOLOGY)

[2015] Scoparone interferes with STAT3-induced proliferation of vascular smooth muscle cells (EXPERIMENTAL AND MOLECULAR MEDICINE)

[2015] Fibroblast growth factor 21 analogue LY2405319 lowers blood glucose in streptozotocin-induced insulin-deficient diabetic mice by restoring brown adipose tissue function (DIABETES OBESITY & METABOLISM)

[2014] Alpha lipoic acid induces hepatic fibroblast growth factor 21 expression via up-regulation of CREBH (BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS)

[2014] Activation of Nrf2 by dimethyl fumarate improves vascular calcification (VASCULAR PHARMACOLOGY)

[2014] Orphan Nuclear Receptor Nur77 Mediates Fasting-Induced Hepatic Fibroblast Growth Factor 21 Expression (ENDOCRINOLOGY)

[2014] Clusterin/Apolipoprotein J Attenuates Angiotensin II-Induced Renal Fibrosis (PLOS ONE)

[2014] The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity (Diabetes and Metabolism Journal)

[2014] The physiological roles of apolipoprotein J/clusterin in metabolic and cardiovascular diseases (REVIEWS IN ENDOCRINE & METABOLIC DISORDERS)

[2014] Physiological Effect and Therapeutic Application of Alpha Lipoic Acid (CURRENT MEDICINAL CHEMISTRY)

[2014] Dimethylfumarate attenuates restenosis after acute vascular injury by cell-specific and Nrf2-dependent mechanisms (REDOX BIOLOGY)

[2013] Scoparone Exerts Anti-Tumor Activity against DU145 Prostate Cancer Cells via Inhibition of STAT3 Activity (PLOS ONE)

[2013] Clusterin Decreases Hepatic SREBP-1c Expression and Lipid Accumulation (ENDOCRINOLOGY)

[2013] Serum irisin levels in new-onset type 2 diabetes (DIABETES RESEARCH AND CLINICAL PRACTICE)

[2013] Dimethylfumarate Suppresses Adipogenic Differentiation in 3T3-L1 Preadipocytes through Inhibition of STAT3 Activity (PLOS ONE)

[2013] Association of 11 beta-hydroxysteroid dehydrogenase type 1 gene polymorphisms with serum alanine aminotransferase activity (DIABETES RESEARCH
AND CLINICAL PRACTICE)

[2013] Clinical Characteristics for 348 Patients with Adrenal Incidentaloma (Endocrinology and Metabolism)

[2013] cAMP response element binding protein H mediates fenofibrate-induced suppression of hepatic lipogenesis (DIABETOLOGIA)

[2013] The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin Resistance (OXIDATIVE MEDICINE AND CELLULAR LONGEVITY)

[2012] Dimethylfumarate Attenuates Renal Fibrosis via NF-E2-Related Factor 2-
Mediated Inhibition of Transforming Growth Factor-β/Smad Signaling (PLoS One.)

[2012] Transcriptional Regulation of Pyruvate Dehydrogenase Kinase (Diabetes and Metabolism Journal)

[2012] Association of the DDAH2 gene polymorphism with type 2 diabetes and hypertension (DIABETES RESEARCH AND CLINICAL PRACTICE)

[2012] An Emerging Diabetes Mellitus Diagnosis Modality: HbA1c (The Korean Journal of Internal Medicine)

[2012] Mediation of glucolipotoxicity in INS-1 rat insulinoma cells by small heterodimer partner interacting leucine zipper protein (SMILE) (BIOCHEMICAL AND
BIOPHYSICAL RESEARCH COMMUNICATIONS)

[2012] Alpha-lipoic acid attenuates vascular calcification via reversal of mitochondrial function and restoration of Gas6/Axl/Akt survival pathway (J Cell Mol Med)

[2012] Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-beta/Smad signaling (FREE RADICAL BIOLOGY AND MEDICINE)

[2012] Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL/6 mice. (Life Sci.)

[2012] Guards and Culprits in the Endoplasmic Reticulum: Glucolipotoxicity and beta-Cell Failure in Type II Diabetes (EXPERIMENTAL DIABETES RESEARCH)

[2012] Clusterin Attenuates the Development of Renal Fibrosis (JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY)

[2011] Relationship of 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase gene polymorphisms with metabolic syndrome and type 2 diabetes (Endocrine Journal)

[2010] alpha-Lipoic Acid Prevents Neointimal Hyperplasia Via Induction of p38 Mitogen-Activated Protein Kinase/Nur77-Mediated Apoptosis of Vascular Smooth Muscle Cells and Accelerates Postinjury Reendothelialization (ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY)

[2010] Trend analysis of diabetic prevalence and incidence in a rural area of South Korea between 2003-2008 (JOURNAL OF DIABETES INVESTIGATION)

[2010] Relationship between cardiovascular autonomic neuropathy and coronary artery calcification in patients with type 2 diabetes (ENDOCRINE JOURNAL)

[2010] Impact of ENPP1 and MMP3 gene polymorphisms on aortic calcification in patients with type 2 diabetes in a Korean population (DIABETES RESEARCH AND CLINICAL PRACTICE)

[2010] Alpha-lipoic acid inhibits hepatic PAI-1 expression and fibrosis by inhibiting the TGF-beta signaling pathway (BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS)

[2010] Endoplasmic Reticulum Stress-Induced Activation of Activating Transcription Factor 6 Decreases cAMP-Stimulated Hepatic Gluconeogenesis via Inhibition of CREB
(ENDOCRINOLOGY)

[2010] Orphan nuclear receptor small heterodimer partner inhibits angiotensin II- stimulated PAI-1 expression in vascular smooth muscle cells (EXPERIMENTAL AND MOLECULAR MEDICINE)

[2009] Cilostazol inhibits high glucose- and angiotensin II-induced type 1 plasminogen activator inhibitor expression in artery wall and neointimal region after vascular injury (ATHEROSCLEROSIS)

[2009] Protective Role of Clusterin/Apolipoprotein J Against Neointimal Hyperplasia via Antiproliferative Effect on Vascular Smooth Muscle Cells and Cytoprotective Effect on Endothelial Cells (ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY)

[2009] Leptin is Negatively Associated with Femoral Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes Mellitus (KOREAN DIABETES JOURNAL)

[2009] Leptin is Negatively Associated with Femoral Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes Mellitus (KOREAN DIABETES JOURNAL)

[2009] Forkhead transcription factor FoxO1 inhibits insulin- and transforming growth factor-beta-stimulated plasminogen activator inhibitor-1 expression (BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS)

[2009] 제2형 당뇨병환자에서 요 알부민 크레아티닌 비와 관상동맥 석회화와의 관련성 (KOREAN DIABETES JOURNAL)

[2009] The Orphan Nuclear Receptor SHP Attenuates Renal Fibrosis (JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY)

[2009] Novel Mutation of Aquaporin-2 Gene in a Patient with Congenital Nephrogenic Diabetes Insipidus (ENDOCRINE JOURNAL)

[2009] Novel LMNA Gene Mutation in a Patient With Atypical Werner’s Syndrome (The Korean Journal of Internal Medicine)

[2009] Activation of NAD(P) H:Quinone Oxidoreductase 1 Prevents Arterial Restenosis by Suppressing Vascular Smooth Muscle Cell Proliferation (CIRCULATION RESEARCH)

[2009] Fabrication of an alpha-lipoic acid-eluting poly-(D,L-lactide-co-caprolactone) cuff for the inhibition of neointimal formation (EXPERIMENTAL AND MOLECULAR
MEDICINE)

[2008] Alpha-Lipoic Acid Decreases Hepatic Lipogenesis Through Adenosine Mono phosphate-Activated Protein Kinase (AMPK)-Dependent and AMPK-Independent
Pathways (HEPATOLOGY)

[2008] Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases insulin gene expression via up-regulation of orphan nuclear receptor small heterodimer partner (ENDOCRINOLOGY)

[2008] 한국인에서 PSMA6 (rs1048990)와 PSMB5 (rs2230087) 유전자 다형성과제2형 당뇨병과의 연관성 (KOREAN DIABETES JOURNAL)

[2007] 한국인에서 제2형 당뇨병과 Kir6.2 및 Peroxisome Proliferator -activated Receptor-gamma (PPARγ) 유전자 다형성의 연관성 (KOREAN DIABETES JOURNAL)

[2007] The modulating effects of the overexpression of uncoupling protein 2 on the formation of reactive oxygen species in vascular cells (DIABETES RESEARCH AND
CLINICAL PRACTICE)

[2007] INS-1 세포에서 SHP에 의해 유도된 유전자발현의 변화에 대한 마이크로어레이 분석 (KOREAN DIABETES JOURNAL)

[2007] Effects of PGC-1 alpha at on TNF-alpha-induced MCP-1 and VCAM-1 expression and NF-kappa B activation in human aortic smooth muscle and endothelial cells (Antioxid Redox Signal)

[2007] Glucotoxicity in the INS-1 rat insulinoma cell line is mediated by the orphan nuclear receptor small heterodimer partner (DIABETES)

[2007] alpha-Lipoic acid inhibits matrix metalloproteinase-9 expression by inhibiting
NF-kappa B transcriptional activity (EXPERIMENTAL AND MOLECULAR MEDICINE)

[2007] Glucocorticoid receptor mediated repression of human insulin gene expression is regulated by PGC-1 alpha (BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS)

[2006] The ascochlorin derivative, AS-6, inhibits TNF-alpha-induced adhesion molecule and chemokine expression in rat vascular smooth muscle cells (LIFE SCIENCES)

[2006] Alpha-lipoic acid inhibits fractalkine expression and prevents neointimal hyperplasia after balloon injury in rat carotid artery (ATHEROSCLEROSIS)

[2006] Effect of AP-1 decoy using hemagglutinating virus of Japan-liposome on the intimal hyperplasia of the autogenous vein graft in mongrel dogs (TRANSPLANTATION PROCEEDINGS)

[2006] Endoplasmic Reticulum (ER) 스트레스와 혈관 합병증 (Diabetes and Metabolism Journal)

[2006] Liver-directed gene therapy of diabetic rats using an HVJ-E vector containing EBV plasmids expressing insulin and GLUT 2 transporter (GENE THERAPY)

[2005] 백서의 혈관평활근세포에서 알파-리포산(alpha-lipoic acid)이 종양괴사인자-알파에 유도된 Fractalkine 발현에 미치는 효과 (KOREAN DIABETES JOURNAL)

[2005] 식이와 운동의 복합 처치후 운동부하에 따른 비만 흰쥐의 혈중 대사기질, 호르몬 및 사이토카인 농도의 변화 (운동과학)

[2005] Effects of recombinant adenovirus-mediated uncoupling protein 2 overexpression on endothelial function and apoptosis (CIRCULATION RESEARCH)

[2005] 폐경 전 여성에서 비만도에 따른 혈중 렙틴 농도와 대사증후군 관련인자와의 상관관계 비교 (Diabetes and Metabolism Journal)

[2005] The effects of the overexpression of recombinant uncoupling protein 2 on proliferation, migration and plasminogen activator inhibitor 1 expression in human vascular smooth muscle cells (DIABETOLOGIA)

[2005] 비만 흰쥐의 6주간 식이제한 및 트레드밀 운동 후 혈중 대사기질, 호르몬 및 사이토카인 농도의 변화 (Journal of Exercise Nutrition & Biochemistry)

[2005] Cilostazol inhibits vascular smooth muscle cell growth by downregulation of the transcription factor E2F (HYPERTENSION)

[2005] Circular dumbbell AP-1 and E2F decoy oligodeoxynucleotide based antiproliferative gene therapy (Gene therapy Molecular Biology)

[2005] E2F decoy oligodeoxynucleotides on neointimal hyperplasia in canine vein graft (TRANSPLANTATION PROCEEDINGS)

[2004] Prevention and treatment of macroangiopathy: focusing on oxidative stress (DIABETES RESEARCH AND CLINICAL PRACTICE)

[2004] Analysis of proteome and transcriptome of tumor necrosis factor alpha stimulated vascular smooth muscle cells with or without alpha lipoic acid (PROTEOMICS)

[2004] 대사조절과 PGC-1α (대한내분비학회지)

[2004] Transcription factor decoy for AP-1 reduces mesangial cell proliferation and extracellular matrix production in vitro and in vivo (GENE THERAPY)

[2004] 폐경 전 비만여성에서 내장지방량에 따른 혈중 아디포넥틴 농도와 대사증후군 관련인자와의 상관관계 (대한내과학회지)

[2004] Relationship between serum adiponectin and leptin concentrations and body fat distribution (DIABETES RESEARCH AND CLINICAL PRACTICE)

[2004] 성인 여성의 비만여부에 따른 신체구성 및 경구당부하검사 비교 (대한스포츠의학
회지)

[2003] Advantages of the circular dumbbell decoy in gene therapy and studies of gene regulation (CURRENT DRUG TARGETS)

[2003] Selective beta-cell loss and beta-cell expansion in patients with type 2 diabetes mellitus in Korea (JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM)

[2003] 스트렙토조토신 유발 당뇨병 백서에서 HVJ-리포좀과 Epstein-Barr Virus Plasmid를 이용한 인슐린 유전자 치료 (KOREAN DIABETES JOURNAL)

[2003] 베타3-아드레날린성 수용체 유전자 변이와 체지방 분포 (대한내분비학회지)

[2003] 뇌졸중 편마비 환자의 골밀도 (대한재활의학회지)

[2003] 제2형 당뇨병 환자에서 Cerivastatin 단기 투여가 혈관내피세포 기능에 미치는 영향 (한국지질동맥경화학회지)

[2002] Novel E2F decoy oligodeoxynucleotides inhibit in vitro vascular smooth muscle cell proliferation and in vivo neointimal hyperplasia (GENE THERAPY)

[2002] Endothelial dysfunction: its relationship with acute hyperglycaemia and hyperlipidemia (INTERNATIONAL JOURNAL OF CLINICAL PRACTICE)

[2001] 혈관 내피세포 기능 평가 (당뇨병)

[2001] 지방세포의 역할과 랩틴수용체의 다형성(Role of Adipocyte & Leptin Receptor Polymorphism) (대한비만학회지)

[2001] 당뇨병성 만성 합병증과 식후고혈당의 새로운 조명 (Medical Postgraduates)

[1999] 하시모토갑상선염의 병리기전 (대한소아내분비학회지)

[1997] Glucose-Induced Protein Kinase C Activation Regulates Vascular Permeability Factor mRNA Expression and Peptide Production by Human Vascular Smooth Mus (대
한당뇨병학회지)

[1997] 혈관질환에 대한 분자생물학적치료 (당뇨병)

[1996] 당뇨병 혈관합병증 발생기전으로 세포사의 역할 및 신호전달체계의 이상 (계명의대논문집)

[1996] 당뇨병 혈관합병증 발생기전으로 세포사의 역할 및 신호전달체계의 이상 (계명의대논문집)

[1994] 당뇨병 합병증에서 미세혈관 및 세포외 기질의 이상 (대한당뇨병학회지)

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