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  #비뇨기종양#남성과학#로봇복강경 수술 및 복강경수술#여성비뇨#헬스조선명의

학력

1988.2 : 중앙대학교 의과대학 석사
1991.2 : 중앙대학교 의과대학 석사
1999.8 : 중앙대학교 의과대학 박사

경력

2009-2012 : 중앙대학교병원 비뇨기과학교실 과장/주임교수
2009-2010 : 중앙대학교의과대학 연구부장, 의학전문대학원 부원장
2008-2009 : 혁신형 암연구중심병원 참여병원 연구 책임자
2009-현재, 보건복지부 주관 비뇨생식기질환 특성화 연구센터 센터장
2012-현재, 교육과학기술부 한국 연구재단 전문위원(review board)

논문

※ 국외 SCI 논문

가. 종양 및 전립선비대증 관련 논문
- Genetic variations in VDR associated with prostate cancer risk and progression in a Korean population. Gene. 2014;533(1):86-93.

- Licochalcone A enhances geldanamycin-induced apoptosis through reactive oxygen species-mediated caspase activation. Pharmacology. 2013;92(1-2):49-59.

- HNF1B polymorphism associated with development of prostate cancer in Korean patients. Urology. 2011 ;78(4):969.e1-6.

- Clinico-epigenetic combination including quantitative methylation value of DKK3 augments survival prediction of the patient with cervical cancer. J Cancer Res Clin Oncol. 2013;139(1):97-106.

- Radicicol, an inhibitor of Hsp90, enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells by promoting activation of apoptosis-related proteins. Mol Cell Biochem. 2012;359(1-2):33-43.

- Prostate specific antigen velocity per prostate volume: a novel tool for prostate biopsy prediction. Urology. 2011;78(4):874-9.

- Sequence variants of Toll-like receptor 4 (TLR4) and the risk of prostate cancer in Korean men. World J Urol. 2012;30(2):225-32.

- Expression of resistin in the prostate and its stimulatory effect on prostate cancer cell proliferation. BJU Int. 2011;108(2 Pt 2):E77-83.

- Relationship between insulin resistance, obesity and serum prostate-specific antigen levels in healthy men. Asian J Androl. 2010 ;12(3):400-4.

- The clinical significance in healthy men of the association between obesity related plasma hemodilution and tumor marker concentration. J Urol. 2009;181(2):567-72; discussion 572-3.

- Clinical significance of the leptin and leptin receptor expressions in prostate tissues. Asian J Androl. 2008;10(6):923-8.

- 18β-glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathway. Mol Cell Biochem. 2012;370(1-2):209-19.

- Variants in the HEPSIN gene are associated with susceptibility to prostate cancer. Prostate Cancer Prostatic Dis. 2012 Dec;15(4):353-8.

- Guanylate cyclase activator YC-1 potentiates apoptotic effect of licochalcone A on human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathways. Eur J Pharmacol. 2012 ;683(1-3):54-62.

- Combined effect of Hsp90 inhibitor geldanamycin and parthenolide via reactive oxygen species-mediated apoptotic process on epithelial ovarian cancer cells. Basic Clin Pharmacol Toxicol. 2012;111(3):173-81.

- Guanylate cyclase activator YC-1 enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells via activation of apoptosis-related proteins. Basic Clin Pharmacol Toxicol. 2011 ;109(4):283-91.

- Indole-3-carbinol inhibits prostate cancer cell migration via degradation of beta-catenin. Oncol Res. 2011;19(5):237-43.

- Different effect of protein kinase B/Akt and extracellular signal-regulated kinase inhibition on trichostatin A-induced apoptosis in epithelial ovarian carcinoma cell lines. Mol Cell Biochem. 2011;353(1-2):1-11.

- Photo-activated 5-hydroxyindole-3-acetic acid induces apoptosis of prostate and bladder cancer cells. J Photochem Photobiol B. 2011 4;103(1):50-6.

- Diarylheptanoid hirsutenone enhances apoptotic effect of TRAIL on epithelial ovarian carcinoma cell lines via activation of death receptor and mitochondrial pathway. Invest New Drugs. 2012;30(2):548-57.

- 18β-Glycyrrhetinic acid potentiates apoptotic effect of trichostatin A on human epithelial ovarian carcinoma cell lines. Eur J Pharmacol. 2010 15;649(1-3):354-61.

- Expression of human β-defensin-2 in the prostate. BJU Int. 2011 ;107(1):144-9.

- Akt inhibitor enhances apoptotic effect of carboplatin on human epithelial ovarian carcinoma cell lines. Eur J Pharmacol. 2010;632(1-3):7-13.

- Fluoxetine induces apoptosis in ovarian carcinoma cell line OVCAR-3 through reactive oxygen species-dependent activation of nuclear factor-kappaB. Basic Clin Pharmacol Toxicol. 2010;106(6):446-53.

- Casein kinase 2 inhibition differentially modulates apoptotic effect of trichostatin A against epithelial ovarian carcinoma cell lines. Mol Cell Biochem. 2010;338(1-2):157-66.

- Extramammary Paget's disease of scrotum treated with radiotherapy. Urology. 2009 ;74(2):474.e1-3.

- Relationship between serum prostate-specific antigen levels and components of metabolic syndrome in healthy men. Urology. 2008 ;72(4):749-54; discussion 754-5.

- Association between serum prostate-specific antigen level, liver function tests and lipid profile in healthy men. BJU Int. 2008;102(9):1097-101.

- Granulocyte macrophage colony-stimulating factor may modulate the post-transcription pathway of interleukin-6 expression in prostate carcinoma cells. J Korean Med Sci. 2008;23(1):94-7.

나. 남성 및 여성비뇨 관련 논문
- Mechanism of Relaxation Via TASK-2 Channels in Uterine Circular Muscle of Mouse. Korean J Physiol Pharmacol. 2013;17(4):359-65.

- The effects of α-defensin 1 on electrical field stimulation-induced contraction of rat bladders. Eur J Pharmacol. 2013 Sep 5;715(1-3):420-3.

- Improvement of andropause symptoms by dandelion and rooibos extract complex CRS-10 in aging male. Nutr Res Pract. 2012;6(6):505-12.

- The effects of smoking and alcohol intake on sperm quality: light and transmission electron microscopy findings. J Int Med Res. 2012;40(6):2327-35.

- The effects of dehydroepiandrosterone (DHEA)/DHEA-sulfate (DHEAS) on the contraction responses of the clitoral cavernous smooth muscle from female rabbits. J Sex Med. 2009 ;6(10):2653-60.

- A novel pathway underlying the inhibitory effects of melatonin on isolated rat urinary bladder contraction. Korean J Physiol Pharmacol. 2012 ;16(1):37-42.

- The Relaxing Effect of α-Defensin 1 on the Adrenergic Responses of Rat Bladder. Korean J Physiol Pharmacol. 2011;15(3):143-7.

- Light and transmission electron microscopic comparisons of sperms between petrochemical factory workers and public servants in a non industrialized area. Fertil Steril. 2010 ;94(7):2864-7.

- Effect of low concentrations of hydrogen peroxide on the contractile responses of rat detrusor smooth muscle strips. Eur J Pharmacol. 2010 25;638(1-3):115-20.

- Pyoderma gangranosum of the penis. J Korean Med Sci. 2009 ;24(6):1200-2.

- Effect of topical application and intraperitoneal injection of oregonin on atopic dermatitis in NC/Nga mice. Exp Dermatol. 2010 ;19(8):e37-43.

- Modulation of human beta-defensin-2 expression by 17beta-estradiol and progesterone in vaginal epithelial cells. Cytokine. 2010 ;49(2):209-14.

- The effect of endothelin-1 on the production of interleukin-6 in cultured human detrusor smooth muscle cells, and the effect of interleukin-6 on the contractile response of bladder smooth muscle strips from rats. BJU Int. 2009;104(5):707-12.

- The effects of interleukin-6 on the contraction and relaxation responses of the cavernous smooth muscle from rats. Eur J Pharmacol. 2008 28;589(1-3):228-32.

- Testosterone relaxes rabbit seminal vesicle by calcium channel inhibition. Korean J Physiol Pharmacol. 2008;12(2):73-7.

- Contractile changes of the clitoral cavernous smooth muscle in female rabbits with experimentally induced overactive bladder. J Sex Med. 2008 ;5(5):1088-96.

- Effects of spermine on the relaxation response of rat detrusor smooth muscles. Eur J Pharmacol. 2007;573(1-3):196-200.

- Effects of L-norgestrel on the endothelium-dependent relaxation response of rabbit clitoral cavernous smooth muscles. Fertil Steril. 2006;86(4 Suppl):1170-4.

- Vasomotor action of insulin on the rabbit normal cavernous smooth muscle. Eur J Pharmacol. 2006;536(1-2):142-7.

- Ionic currents in single smooth muscle cells of the human vas deferens. J Urol. 2004;172(2):628-33.

다. 결석 및 감염 관련 논문
- Correlation of metabolic syndrome with urinary stone composition. Int J Urol. 2013 Feb;20(2):208-13.

- Metabolic syndrome, urine pH, and time-dependent risk of nephrolithiasis in Korean men without hypertension and diabetes. Urology. 2011 ;78(4):753-8.

- NS-398 (a selective cyclooxygenase-2 inhibitor) decreases agonist-induced contraction of the human ureter via calcium channel inhibition. J Endourol. 2010;24(11):1863-8. doi: 10.1089/end.2009.0461.

- Development of a novel PCR assay based on the 16S-23S rRNA internal transcribed spacer region for the detection of Lactococcus garvieae. J Fish Dis. 2012 Jul;35(7):481-7.

- Comparative transcriptomic analysis of streptococcus pseudopneumoniae with viridans group streptococci. BMC Microbiol. 2012; 6;12:77.

- Algoriphagus chungangensis sp. nov., isolated from a tidal flat sediment. Int J Syst Evol Microbiol. 2013 ;63(Pt 2):648-53.

- Haloferula chungangensis sp. nov., isolated from marine sediment. Int J Syst Evol Microbiol. 2013;63(Pt 1):19-24.

- Identification of a pheA gene associated with Streptococcus mitis by using suppression subtractive hybridization. Appl Environ Microbiol. 2012 ;78(8):3004-9.

- Genomic characterization of a cell-culture-adapted Korean human G9P[8] rotavirus, CAU05-202. Arch Virol. 2012;157(4):753-9.

- Identification of the cpsA gene as a specific marker for the discrimination of Streptococcus pneumoniae from viridans group streptococci. J Med Microbiol. 2010 ;59(Pt 10):1146-52.

- Genetic characterization of norovirus GII.4 2006b variants from Jeju island, South Korea. J Med Virol. 2010 ;82(6):1065-70.

- Flavobacterium ponti sp. nov., isolated from seawater. Int J Syst Evol Microbiol. 2011;61(Pt 1):81-5. doi: 10.1099/ijs.0.017582-0.

- Pseudoclavibacter chungangensis sp. nov., isolated from activated sludge. Int J Syst Evol Microbiol. 2010 ;60(Pt 7):1672-7.

- Association between metabolic syndrome and chronic kidney disease in the Korean population. Nephrology (Carlton). 2009;14(3):321-6.

※ 국내 논문

- Effectiveness of flexible ureteroscopic stone removal for treating ureteral and ipsilateral renal stones: a single-center experience. Korean J Urol. 2013;54(6):377-82.

- Relaxing effect of acetylcholine on phenylephrine-induced contraction of isolated rabbit prostate strips is mediated by neuronal nitric oxide synthase. Korean J Urol. 2013 May;54(5):333-8.

- Delayed presentation of intravesical bone penetration after pelvic ring fracture. Korean J Urol. 2012 Dec;53(12):887-9.

- Influence of overweight on 24-hour urine chemistry studies and recurrent urolithiasis in children. Korean J Urol. 2012;53(4):268-74.

- Impact of changing trends in medical therapy on surgery for benign prostatic hyperplasia over two decades. Korean J Urol. 2012;53(1):23-8.

- Effect of Prostate Biopsy Hemorrhage on MRDW and MRS Imaging. Korean J Urol. 2011;52(10):674-80.

- Possible Relationship between Metabolic Syndrome Traits and Nephrolithiasis: Incidence for 15 Years According to Gender. Korean J Urol. 2011;52(8):548-53.

- Detection of nanobacteria in patients with chronic prostatitis and vaginitis by reverse transcriptase polymerase chain reaction. Korean J Urol. 2011 ;52(3):194-9.

- Leptin enhances nitric oxide-dependent relaxation of the clitoral corpus cavernosum. Korean J Urol. 2011;52(2):136-41.

- Significance of S100A2 and S100A4 Expression in the Progression of Prostate Adenocarcinoma. Korean J Urol. 2010;51(7):456-62.

- 레지스틴의 발현과 전립선암 세포분화 및 진행의 상관관계 대한비뇨기과학회지 2009; 50(06): 540-552.

- 전립선특이항원 선별검사 도입에 따른 전립선암의 임상병리학적 특성의 변화 대한비뇨기과학회지 2009; 50(05): 439-444.

- Adiponectin과 Leptin이 전립선암 세포의 증식에 미치는 영향 대한비뇨기과학회지 2009;50(05): 493-497.

- 여성 단순급성신우신염 환자에서 혈중 및 요중 싸이토카인의 임상적 유용성 대한비뇨기과학회지 2009;50(01): 33-38.

- 전립선암에서 조직 내 Tubulin ?와 ?II 발현의 임상적 의의 대한비뇨기과학회지 2008; 49(08): 709-714.

- 바소프레신과 데스모프레신이 가토 음경해면체 평활근의 수축 및 이완에 미치는 영향 대한비뇨기과학회지 2008;49(04): 366-372.

- 한국 요석 환자의 Eta-1/Osteopontin 유전자 다형성 분석 대한비뇨기과학회지 2008;49(01): 55-59.

- 근치적 신절제술 후 방광에 전이된 신세포암 대한비뇨기과학회지 2007;48(10): 1088-1091.

- 만성전립선염에서 다중 중합효소연쇄반응을 이용한 잠복 미생물의 검출 대한비뇨기과학회지 2007;48(03): 304-309.

- 전립선암 세포주에서 Peroxiredoxin I과 c-Myc에 의한 인간 Telomerase 역전사효소 유전자 발현의 억제 대한비뇨기과학회지 2006;47(04): 418-425.

- 전립선암세포주에서 선택적 Cyclooxygenase-2 억제제와 Prostaglandin E2 수용체 효현제가 Endothelin계에 미치는 영향 대한비뇨기과학회지 2006; 047(02): 195-200.

- 음경환상 피부절제술 시 발생한 음경절단의 육안적 재접합 대한비뇨기과학회지 2005;46(12): 1360-1362.

- Interleukin-1beta가 전립선암세포 PC-3 및 DU-145의 증식력과 Interleukin-6 및 Interleukin-6 수용체 mRNA 발현에 미치는 영향 대한비뇨기과학회지 2004;45(08): 810-816.

- 전립선암세포주 PC-3에서 Prostagladin E 수용체 II, IV에 의한 Martrix Metalloproteinase-7의 발현 증가 대한비뇨기과학회지 2004; 45(05): 478-484.


Mechanism of Relaxation Via TASK-2 Channels in Uterine Circular Muscle of Mouse KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, C/O EDITORIAL OFFICE, 448-13 SEOKYO-DONG, SEOUL, SOUTH KOREA 2013.08.01

Licochalcone A enhances geldanamycin-induced apoptosis through reactive oxygen species-mediated caspase activation PHARMACOLOGY KARGER, ALLSCHWILERSTRASSE 10, BASEL, SWITZERLAND, CH-4009 2013.02.01

Effectiveness of flexible ureteroscopic stone removal for treating ureteral and ipsilateral renal stones: a single-center experience Korean Journal of Urology Korean Urological Association 2013.06.01

Relaxing effect of acetylcholine on phenylephrine-induced contraction of isolated rabbit prostate strips is mediated by neuronal nitric oxide synthase Korean Journal of Urology Korean Urological Association 2013.05.01

The effects of α-defensin 1 on electrical field stimulation-induced contraction of rat bladders EUROPEAN JOURNAL OF PHARMACOLOGY ELSEVIER SCIENCE BV, PO BOX 211, AMSTERDAM, NETHERLANDS, 1000 AE 2013.09.05

Correlation of metabolic syndrome with urinary stone composition INTERNATIONAL JOURNAL OF UROLOGY WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN, USA, NJ, 07030-5774 2013.02.01

Clinico-epigenetic combination including quantitative methylation value of DKK3 augments survival prediction of the patient with cervical cancer JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY SPRINGER, 233 SPRING ST, NEW YORK, USA, NY, 10013 2013.01.01

Algoriphagus chungangensis sp. nov., isolated from a tidal flat sediment INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY SOC GENERAL MICROBIOLOGY, MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING, ENGLAND, BERKS, RG7 1AG 2013.02.01

Haloferula chungangensis sp. nov., isolated from marine sediment INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY SOC GENERAL MICROBIOLOGY, MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING, ENGLAND, BERKS, RG7 1AG 2013.01.01

저서

웃는 여자 우는 여자

여성 비뇨기과 크리닉

보도자료

높아지는 여성 비뇨기질환 병원은 잘 안가
http://www.monews.co.kr/news/articleView.html?idxno=99273

[명순철 건강 칼럼]화장실 자주 가는 당신, 날씨 탓? 예민한 방광 탓?
http://weekly.cnbnews.com/news/article.html?no=112196

[건강이 최고] 여성이 비뇨기과에 가야 할 증상 10가지
https://www.yna.co.kr/view/AKR20170428116600017?input=1195m

화장실이 어디 있죠? 참을 수 없는 ‘마려움’
http://www.k-health.com/news/articleView.html?idxno=36617

[전립선 질환 예방하기] 전립선염의 치료와 예방
http://withinnews.co.kr/news/view.html?section=1&category=97&item=&no=20075

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