최혜진

  #간암#췌장암#담도암#신경내분비종양#뇌종양#항암약물치료#신약치료#완화의료

학력

1995.03~2001.02 연세대학교 학사
2004.03~2006.02 연세대학교 석사
2007.09~ 2014.8 연세대학교 박사

경력

2001.03~2006.02 세브란스병원 인턴, 레지던트
2006.03~2008.02 세브란스병원 혈액종양내과 강사
2008.03~2009.02 연세의대 내과학교실 종양내과 임상연구조교수
2009.03~2015.01 연세의대 내과학교실 종양내과 임상조교수
2015.02~2019.02 연세의대 내과학교실 종양내과 조교수
2019.03~ 현 재 연세의대 내과학교실 종양내과 부교수

논문

진행성 간암의 치료, 대한간암연구회지, 2011년 제11호

전이성 간암의 치료, 대한내과학회지, 2011년 제81권 3호

Congenital absence of inferior vena cava as a rare cause of pulmonary thromboembolism
YONSEI MEDICAL JOURNAL 45/ :947-951,2004

항인지질 증후군 환자에서 동반된 간문맥 혈전증 1예
대한내과학회지(korean Journal of medcine) 68/1 :99-104,2005

A pilot study of trans-arterial injection of 166Holmium-Chitosan complex for treatment of small hepatocellular carcinoma
YONSEI MEDICAL JOURNAL 46/6 :799-805,2005

Cetuximab rescue a patient with non-small cell lung cancer from rapid disease progression during chemotherapy
ACTA ONCOLOGICA 46/4 :547-549,2007

Phase II trial of irinotecan and cisplatin with early concurrent radiotherapy in limited-disease small-cell lung cancer
CANCER 109/9 :1845-1850,2007

Phase II study of erlotinib in advanced non-small-cell lung cancer after failure of gefitinib
JOURNAL OF CLINICAL ONCOLOGY 25/18 :2528-2533,2007

Prognostic impact of resection margin involvement after extended (D2/D3) gastrectomy for advanced gastric cancer: A 15-year experience at a single Institute
JOURNAL OF SURGICAL ONCOLOGY 95/ :461-468,2007

VEGF-specific short hairpin RNA-expressing oncolytic adenovirus elicits potent inhibition of angiogenesis and tumor growth
MOLECULAR THERAPY 15/2 :295-302,2007

Phase I trial of neoadjuvant concurrent chemoradiotherapy with S-1 and weekly irinotecan in locally advanced rectal cancer
Radiotherapy And Oncology 87/ :361-366,2008

Capecitabine and doxorubicin combination chemotherapy as salvage therapy in pretreated advanced gastric cancer
Cancer Chemotherapy And Pharmacology 61/ :157-165,2008

The combination of capecitabine and irinotecan in treating 5-Fluorouracil- and Oxaliplatin-pretreated metastatic colorectal cancer
Cancer Chemotherapy And Pharmacology 61/ :75-81,2008

A single institutional experience of surgically resected thymic epithelial tumors over 10 years - Clinical outcomes and clinicopathologic features
Oncology Reports 19/ :1525-1531,2008

Combination of topotecan and etoposide as a salvage treatment for patients with recurrent small cell lung cancer following irinotecan and platinum first-line chemotherapy
Cancer Chemotherapy And Pharmacology 61/ :309-313,2008

Standardization of the Korean version of Mini-Mental Adjustment to Cancer (K-Mini-MAC) scale: factor structure, reliability and validity
Psycho-Oncology 17/ :592-597,2008

The number of residual metastatic lymph nodes following neoadjuvant chemotherapy predicts survival in patients with stage III NSCLC
Lung Cancer 60/3 :393-400,2008

Phase II Study of Transarterial Holmium-166-Chitosan Complex Treatment in Patients with a Single, Large Hepatocellular Carcinoma
Oncology 76/1 :1-9,2009

Activating mutations within the EGFR kinase domain: a molecular predictor of disease-free survival in resected pulmonary adenocarcinoma
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 135/12 :1647-1654,2009

High tumor metabolic activity as measured by fluorodeoxyglucose positron emission tomography is associated with poor prognosis in limited and extensive stage small-cell lung cancer
Clinical Cancer Research 15/7 :2426-2432,2009

Double E1B 19 kDa- and E1B 55 kDa-deleted oncolytic adenovirus in combination with radiotherapy elicits an enhanced anti-tumor effect
GENE THERAPY 16/ :1111-1121,2009

Weekly docetaxel in patients with platinum-refractory metastatic or recurrent squamous cell carcinoma of the head and neck
CANCER CHEMOTHERAPY AND PHARMACOLOGY 65/1 :27-32,2009

Brain metastases from hepatocellular carcinoma: prognostic factors and outcome
Journal Of Neuro-Oncology 91/3 :307-313,2009

Complete Response of Recurrent Squamous Cell Carcinoma of the Lung: Dose the Dose Matter?
Journal Of Thoracic Oncology 4/1 :141-142,2009

Weekly 5-fluorouracil plus cisplatin for concurrent chemoradiotherapy in patients with locally advanced head and neck cancer
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 32/2 :235-243,2010

Frequent central nervous system failure after clinical benefit with epidermal growth factor receptor tyrosine kinase inhibitors in Korean patients with nonsmall-cell lung cancer
Cancer 116/5 :1336-1343,2010

Phase II study of preoperative chemoradiotherapy (CRT) with irinotecan plus S-1 in locally advanced rectal cancer
Radiotherapy And Oncology 95/3 :303-307,2010

Paclitaxel combined with ifosfamide in anthracycline- and docetaxel-pretreated metastatic breast cancer: activity independence of prior docetaxel resistance
CANCER CHEMOTHERAPY AND PHARMACOLOGY 66/3 :425-431,2010

Belotecan for relapsing small-cell lung cancer patients initially treated with an irinotecan-containing chemotherapy: A phase II trial
Lung Cancer 70/1 :77-81,2010

Outcome of Adjuvant Therapy for Gallbladder Cancer
Oncology 79/3-4 :168-173,2010

Prognostic Factors in Small Cell Lung Cancer: A New Prognostic Index in Korean Patients
Oncology 79/3-4 :293-300,2010

MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation
ONCOLOGY REPORTS 25/2 :537-544,2011

A phase I study of nimotuzumab in combination with radiotherapy in stages IIB-IV non-small cell lung cancer unsuitable for radical therapy: Korean results
LUNG CANCER 71/1 :55-59,2011

Long-term clinical outcomes of hepatic arterial infusion chemotherapy with cisplatin with or without 5-fluorouracil in locally advanced hepatocellular carcinoma
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 137/4 :659-667,2011

Evaluation of Bone Metastasis from Hepatocellular Carcinoma Using 18F-FDG PET/CTand 99mTc-HDP Bone Scintigraphy: Characteristics of Soft Tissue Formation
Nuclear Medicine and Molecular Imaging 45/3 :203-211,2011

Serous Cystic Neoplasm: Do We Have to Wait Till It Causes Trouble?
Korean Journal Of Hepato-Biliary-Pancreatic Surgery(한국간담췌외과학회지) 15/2 :134-138,2011

Prognostic value of 18F-FDG PET for hepatocellular carcinoma patients treated with sorafenib
LIVER INTERNATIONAL 31/8 :1144-1149,2011

진행성 간암에서 전신 요법
대한간암연구학회지 11/1 :33-39,2011

전이성 간암의 치료
Korean J Med 81/3 :279-288,2011

항암화학요법을 받는 환자의 구강관리 프로토콜개발 및 적용효과
임상간호연구 17/1 :113-122,2011

Potential Contribution of Preoperative Neoadjuvant Concurrent Chemoradiation Therapy on Margin-Negative Resection in Borderline Resectable Pancreatic Cancer
JOURNAL OF GASTROINTESTINAL SURGERY 16/3 :509-517,2012

Gemcitabine and oxaliplatin with or without erlotinib in advanced biliary-tract cancer: a multicentre, open-label, randomised, phase 3 study
LANCET ONCOLOGY 13/2 :181-188,2012

In Vitro Adenosine Triphosphate-Based Chemotherapy Response Assay (ATP-CRA) in Solid Pseudopapillary Tumor of the Pancreas
PANCREAS 41/3 :498-500,2012

Sorafenib versus cytotoxic chemotherapy for patients with advanced hepatocellular carcinoma: a retrospective, single-institution study
INVESTIGATIONAL NEW DRUGS 30/3 :1150-1157,2012

동영상 운동프로그램이 항암 화학요법을 받는 암환자의 피로와 신체기능 및 정서상태에 미치는 효과
임상간호연구 18/3 :368-380,2012

Randomized controlled trial of standardized education and telemonitoring for pain in outpatients with advanced solid tumors
SUPPORTIVE CARE IN CANCER 21/6 :1751-1759,2013

Prognostic Value of 18F-Fluorodeoxyglucose Positron Emission Tomography in Patients with Resectable Pancreatic Cancer
YONSEI MEDICAL JOURNAL 54/6 :1377-1383,2013

Better Outcome of XELOX Chemotherapy in Patients with Advanced Intestinal-Type Adenocarcinoma of the Ampulla of Vater
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 231/ :21-28,2013

Two Cases of Humoral Hypercalcemia of Malignancy in Metastatic Cholangiocarcinoma
Cancer Research and Treatment 45/2 :145-149,2013

Prolonged clinical benefit from the maintenance hormone therapy in patients with metastatic breast cancer
BREAST 22/6 :1205-1209,2013

Prognostic Value of Metabolic Tumor Volume and Total Lesion Glycolysis on Preoperative 18F-FDG PET/CT in Patients with Pancreatic Cancer
JOURNAL OF NUCLEAR MEDICINE 55/6 :898-904,2014

Prognostic Significance of Volume-Based FDG PET/CT Parameters in Patients with Locally Advanced Pancreatic Cancer Treated with Chemoradiation Therapy
YONSEI MEDICAL JOURNAL 55/6 :1498-1506,2014

Hepatocellular carcinoma specific graded prognostic assessment can predict outcomes for patients with brain metastases from hepatocellular carcinoma
JOURNAL OF NEURO-ONCOLOGY 120/1 :199-207,2014

A phase II study of the efficacy and safety of the combination therapy of the MEK inhibitor refametinib (BAY 86-9766) plus sorafenib for Asian patients with unresectable hepatocellular carcinoma
CLINICAL CANCER RESEARCH 20/23 :5976-5985,2014

18F-FDG PET/CT in hepatocellular carcinoma: Detection of bone metastasis and prediction of prognosis
NUCLEAR MEDICINE COMMUNICATIONS 36/3 :226-233,2015

Ratio of phosphorylated HSP27 to nonphosphorylated HSP27 biphasically acts as a determinant of cellular fate in gemcitabine-resistant pancreatic cancer cells
CELLULAR SIGNALLING 27/4 :807-817,2015

Prognostic significance of standardized uptake value on preoperative 18F-FDG PET/CT in patients with ampullary adenocarcinoma
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 42/6 :841-847,2015

Pain Palliation in Patients with Bone Metastases Using Magnetic Resonance-Guided Focused Ultrasound with Conformal Bone System: A Preliminary Report
YONSEI MEDICAL JOURNAL 56/2 :503-509,2015

Molecular Subgroup Analysis of Clinical Outcomes in a Phase 3 Study of Gemcitabine and Oxaliplatin with or without Erlotinib in Advanced Biliary Tract Cancer
TRANSLATIONAL ONCOLOGY 8/1 :40-46,2015

Prediction of short- and long-term survival for advanced cancer patients after ICU admission
SUPPORTIVE CARE IN CANCER 23/6 :1647-1655,2015

Hepatitis B viral load predicts survival in hepatocellular carcinoma patients treated with sorafenib
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 30/6 :1024-1031,2015

Results of a Phase II Study to Evaluate the Efficacy of Docetaxel and Carboplatin in Metastatic Malignant Melanoma Patients Who Failed First-Line Therapy Containing Dacarbazine
CANCER RESEARCH AND TREATMENT 74/4 :781-789,2015

Pseudoprogression in glioblastoma patients: the impact of extent of resection
JOURNAL OF NEURO-ONCOLOGY 126/3 :559-566,2016

Survivin silencing and TRAIL expression using oncolytic adenovirus increase anti-tumorigenic activity in gemcitabine-resistant pancreatic cancer cells.
APOPTOSIS 21/3 :351-364,2016

Characteristics of Venous Thromboembolism in Pancreatic Adenocarcinoma in East Asian Ethnics : A Large Population-Based Observational Study.
MEDICINE 95/17 :e3472-,2016

Prime-boost immunization by both DNA vaccine and oncolytic adenovirus expressing GM-CSF and shRNA of TGF-β2 induces anti-tumor immune activation
ONCOTARGET 8/9 :15,858-15,877,2017

Down-regulation of TGF-β expression sensitizes the resistance of hepatocellular carcinoma cells to sorafenib
YONSEI MEDICAL JOURNAL 58/5 :899-909,2017

Long-term outcomes of concomitant chemoradiotherapy with temozolomide for newly diagnosed glioblastoma patients A single-center analysis
MEDICINE 96/27 :e7422-,2017

Outpatient Palliative Care and Aggressiveness of End-of-Life Care in Patients with Metastatic Colorectal Cancer.
AMERICAN JOURNAL OF HOSPICE & PALLIATIVE MEDICINE 35/1 :166-172,2018

Multiple systemic extraneural metastasis of glioblastoma
Chirurgia 31/1 :39-43,2018

TGF-β downregulation-induced cancer cell death is finely regulated by SAPKs signaling cascade
EXPERIMENTAL AND MOLECULAR MEDICINE 50/ :162-180,2018

Distinct immunological properties of the two histological subtypes of adenocarcinoma of the ampulla of Vater
CANCER IMMUNOLOGY IMMUNOTHERAPY 68/3 :443-454,2019

Interprofessional Collaboration Between a Multidisciplinary Palliative Care Team and the Team Pharmacist on Pain Management.
AMERICAN JOURNAL OF HOSPICE & PALLIATIVE MEDICINE 36/7 :616-622,2019

An Open-Label, Multicenter, Phase I, Dose Escalation Study with Phase II Expansion Cohort to Determine the Safety, Pharmacokinetics, and Preliminary Antitumor Activity of Intravenous TKM-080301 in Subjects with Advanced Hepatocellular Carcinoma.
ONCOLOGIST 24/6 :747-e218,2019

High levels of Daxx due to low cellular levels of HSP25 in murine cancer cells result in inefficient adenovirus replication
EXPERIMENTAL AND MOLECULAR MEDICINE 51/122 :122-141,2019

Real-world efficacy and safety of liposomal irinotecan plus fluorouracil/leucovorin in patients with metastatic pancreatic adenocarcinoma: a study by the Korean Cancer Study Group.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY 11/ :1-9,2019

Capecitabine plus oxaliplatin versus gemcitabine plus oxaliplatin as first-line therapy for advanced biliary tract cancers: a multicenter, open-label, randomized, phase III, noninferiority trial
ANNALS OF ONCOLOGY 30/5 :788-795,2019

Significance of Metabolic Tumor Volume and Total Lesion Glycolysis Measured Using ¹?F-FDG PET/CT in Locally Advanced and Metastatic Gallbladder Carcinoma.
YONSEI MEDICAL JOURNAL 60/7 :604-610,2019

Mesothelin Expression Is a Predictive Factor for Peritoneal Recurrence in Curatively Resected Stage III Gastric Cancer
ONCOLOGIST 24/11 :e1108-e1114,2019

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