박정엽

  #췌장암#담도암#췌담도계양성질환#신경내분비종양#항암치료#치료내시경

학력

연세대학교 의학과 학사 (1997)
연세대학교 의학과 석사 (2001)
인하대학교 박사 (2011)

경력

1997-1998 연세대학교 의과대학 내과학교실인턴 수료
1998-2002 연세대학교 의과대학 내과학교실 레지던트 수료
2002-2005 공중보건의
2005-2008 연세대학교 의과대학 내과학교실 연구강사
2008-2008 인하대학교 부속 병원 임상강사
2008-2009 인하대학교 의과대학 소화기내과 조교수
2009-2014 연세대학교 의과대학 내과학교실 조교수
2014-2019 연세대학교 의과대학 내과학교실 부교수
2019- 현재 연세대학교 의과대학 내과학교실 교수

논문

Treatment outcome of transcatheter arterial chemoinfusion according to anticancer agents and prognostic factors in patients with advanced hepatocellular carcinoma (TNM stage IVa)
YONSEI MEDICAL JOURNAL 45/5 :847-858,2004

Long-term clinical outcome of large volume paracentesis with intravenous albumin in patients with spontaneous bacterial peritonitis: A randomized prospective study
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 20/ :1215-1222,2005

The clinicopathologic significance of the expression of vascular endothelial growth factor-C in intrahepatic cholangiocarcinoma
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS 29/ :138-142,2006

Phase II study of cisplatin combined with weekly gemcitabine in the treatment of patients with metastatic pancreatic carcinoma
PANCREATOLOGY 6/ :635-641,2006

Endoscopic papillary balloon dilation with large balloon after limited sphincterotomy for retrieval of choledocholithiasis
YONSEI MEDICAL JOURNAL 47/6 :805-810,2006

Phase II study of gemcitabine and cisplatin in advanced biliary tract cancer
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 21/ :999-1003,2006

Bile acid analysis in biliary tract cancer
YONSEI MEDICAL JOURNAL 47/6 :817-825,2006

Concurrent chemoradiotherapy with doxifluridine and paclitaxel for extrahepatic bile duct cancer
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS 29/ :240-245,2006

Hepatic artery pseudoaneurysm associated with plastic biliary stent
YONSEI MEDICAL JOURNAL 48/3 :546-548,2007

Up-regulated claudin 7 expression in intestinal-type gastric carcinoma
ONCOLOGY REPORTS 18/ :377-382,2007

CXCL5 overexpression is associated with late stage gastric cancer
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 133/11 :835-840,2007

Analysis of the Effects of Stent Insertion and the Factors Related to Stent Retrieval in Chronic Pancreatitis Accompanying Main Pancreatic Duct Obstruction
Gut and Liver 1/1 :63-67,2007

ATP-Based chemotherapy response assay in patients with unresectable gastric cancer
ONCOLOGY 73/73 :439-440,2007

Weekly full-dose gemcitabine and single-dose cisplatin with concurrent radiotherapy in patients with locally advanced pancreatic cancer
British Journal Of Cancer 98/ :881-887,2008

Expression of nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1) inversely correlates with tumor progression in gastric adenomas and carcinomas
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 134/9 :1029-1035,2008

Effectiveness of self-expanding metal stents for malignant antropyloric and duodenal obstruction with a comparison between covered and uncovered stents
Hepato-Gastroenterology 55/88 :2091-2095,2008

Phase II trial of S-1 and concurrent radiotherapy in patients with locally advanced pancreatic cancer
CANCER CHEMOTHERAPY AND PHARMACOLOGY 63/ :535-541,2009

Phase II study of 5-fluorouracil and paclitaxel in patients with gemcitabine-refractory pancreatic cancer
CANCER CHEMOTHERAPY AND PHARMACOLOGY 63/3 :529-533,2009

First clinical trial of the MiRo capsule endoscope by using a novel transmission technology: electric-field propagation
GASTROINTESTINAL ENDOSCOPY 69/2 :253-259,2009

Long-term follow up of gallbladder polyps
Journal Of Gastroenterology And Hepatology 24/ :219-222,2009

Cripto-1 overexpression is involved in the tumorigenesis of gastric-type and pancreatobiliary-type intraductal papillary mucinous neoplasms of the pancreas
Oncology Reports 21/1 :19-24,2009

Hypoechoic foci on EUS are simple and strong predictive factors for neoplastic gallbladder polyps
GASTROINTESTINAL ENDOSCOPY 69/ :1244-1250,2009

Self-Expandable Metal Stents for Recurrent Malignant Obstruction after Gastric Surgery
Hepato-Gastroenterology 56/91-92 :914-917,2009

급성 췌장염을 동반한 불완전 분할췌와 담췌관합류이상 기형이 동반된 소아 환자의 내시경 치료
Korean Journal Of Gastroenterology 54/5 :333-336,2009

A Pilot Study of Sequential Capsule Endoscopy Using MiroCam and PillCam SB Devices with Different Transmission Technologies
GUT AND LIVER 4/2 :192-200,2010

Active locomotion of a paddling-based capsule endoscope in an in vitro and in vivo experiment (with videos)
GASTROINTESTINAL ENDOSCOPY 72/2 :381-387,2010

Oct4 and Nanog Expression Is Associated With Early Stages of Pancreatic Carcinogenesis
Pancreas 39/5 :622-626,2010

Intraductal ultrasonography combined with percutaneous transhepatic cholangioscopy for the preoperative evaluation of longitudinal tumor extent in hilar cholangiocarcinoma
Journal of Gastroenterology and Hepatology 25/2 :286-292,2010

Signet Ring Cell Carcinoma of the Extrahepatic Bile Duct
GUT AND LIVER 4/3 :402-406,2010

Longer Capsule Endoscopy Operation Time Increases the Rate of Complete Examination of the Small Bowel
Hepato-Gastroenterology 57/101 :746-750,2010

Placement of a fully covered self-expandable metal stent in a young patient with chronic pancreatitis
World Journal of Gastrointestinal Endoscopy 2/11 :375-378,2010

Development, Validation, and Responsiveness of a Novel Disease Activity Index for Intestinal Behcet's Disease
INFLAMMATORY BOWEL DISEASES 17/2 :605-613,2011

Comparison of outcomes among secondary covered metallic, uncovered metallic, and plastic biliary stents in treating occluded primary metallic stents in malignant distal biliary obstruction
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 25/2 :475-482,2011

췌장암의 2차 항암치료
대한소화기학회지(The Korean Journal of Gastroenterology) 57/4 :207-212,2011

Preoperative Serum CA 19-9 Level as a Predictive Factor for Recurrence after Curative Resection in Biliary Tract Cancer
ANNALS OF SURGICAL ONCOLOGY 18/6 :1651-1656,2011

Prospective Phase II Trial of Gemcitabine in Combination with Irinotecan as First-Line Chemotherapy in Patients with Advanced Biliary Tract Cancer
CHEMOTHERAPY 57/3 :236-243,2011

Primary intestinal lymphangiectasia diagnosed by capsule endoscopy and double balloon enteroscopy
World Journal of Gastrointestinal Endoscopy 3/11 :235-240,2011

Proteomic analysis of pancreatic juice for the identification of biomarkers of pancreatic cancer
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 137/8 :1229-1238,2011

Serous Cystic Neoplasm: Do We Have to Wait Till It Causes Trouble?
Korean Journal Of Hepato-Biliary-Pancreatic Surgery(한국간담췌외과학회지) 15/2 :134-138,2011

Endoscopic Management of Afferent Loop Syndrome after a Pylorus Preserving Pancreatoduodenecotomy Presenting with Obstructive Jaundice and Ascending Cholangitis
Clinical Endoscopy 44/1 :59-64,2011

The sonic hedgehog pathway as a treatment target for extrahepatic biliary tract cancer
MOLECULAR MEDICINE REPORTS 5/ :12-16,2012

Potential Contribution of Preoperative Neoadjuvant Concurrent Chemoradiation Therapy on Margin-Negative Resection in Borderline Resectable Pancreatic Cancer
JOURNAL OF GASTROINTESTINAL SURGERY 16/3 :509-517,2012

A novel disposable, transnasal esophagoscope: a pilot trial of feasibility, safety, and tolerance
ENDOSCOPY 44/2 :206-209,2012

Clinical features and outcomes of primary hepatic neuroendocrine carcinomas
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 27/ :1306-1311,2012

Safety of Capsule Endoscopy Using Human Body Communication in Patients with Cardiac Devices
DIGESTIVE DISEASES AND SCIENCES 57/6 :1719-1723,2012

Prognostic Factors and Characteristics of Pancreatic Neuroendocrine Tumors: Single Center Experience
YONSEI MEDICAL JOURNAL 53/5 :944-951,2012

Clinical Implications and Risk Factors of Acute Pancreatitis after Cardiac Valve Surgery
YONSEI MEDICAL JOURNAL 54/1 :154-159,2013

Serum CA 19-9 and CEA levels as a prognostic factor in pancreatic adenocarcinoma
YONSEI MEDICAL JOURNAL 54/3 :643-649,2013

Clinicopathologic Features and Outcomes of Pancreatic Cysts During a 12-Year Period
PANCREAS 42/2 :230-238,2013

Gastrointestinal Hemorrhage after Concurrent Chemoradiotherapy in Locally Advanced Pancreatic Cancer
GUT AND LIVER 7/1 :106-111,2013

Clinical advantages of a metal stent with an S-shaped anti-reflux valve in malignant biliary obstruction
DIGESTIVE ENDOSCOPY 25/3 :308-312,2013

Differential diagnosis between gallbladder adenomas and cholesterol polyps on contrast-enhanced harmonic endoscopic ultrasonography
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 27/4 :1414-1421,2013

Comparison of the Sixth and Seventh Editions of the AJCC TNM Classification for Gallbladder Cancer
JOURNAL OF GASTROINTESTINAL SURGERY 17/5 :925-930,2013

The use of health functional foods in gastrointestinal cancer patients
Clinical nutrition research 2/1 :19-25,2013

Endoscopic Papillary Large Balloon Dilatation Alone Is Safe and Effective for the Treatment of Difficult Choledocholithiasis in Cases of Billroth II Gastrectomy: A Single Center Experience
DIGESTIVE DISEASES AND SCIENCES 58/6 :1737-1743,2013

Radiotherapy Prolongs Biliary Metal Stent Patency in Malignant Pancreatobiliary Obstructions
GUT AND LIVER 7/4 :480-485,2013

Gemcitabine based neoadjuvant chemoradiotherapy therapy in patients with borderline resectable pancreatic cancer
PANCREATOLOGY 13/5 :539-543,2013

Phase II Trial of Erlotinib Plus Gemcitabine Chemotherapy in Korean Patients with Advanced Pancreatic Cancer and Prognostic Factors for Chemotherapeutic Response
GUT AND LIVER 7/5 :611-615,2013

Folfox4 as a Rescue Chemotherapy for Gemcitabine-Refractory Pancreatic Cancer
HEPATO-GASTROENTEROLOGY 60/122 :363-367,2013

재발성 췌장암으로 항암화학요법을 시행한 환자에서 발생한 복부 방선균증
대한내과학회지 85/4 :401-405,2013

High serum CA19-9 levels are associated with an increased risk of cholangiocarcinoma in patients with intrahepatic duct stones: a case-control study
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 27/11 :4210-4216,2013

Prognostic Value of Model for End-Stage Liver Disease Scores in Patients with Fulminant Hepatic Failure
TRANSPLANTATION PROCEEDINGS 45/8 :2992-2994,2013

Efficacy of concurrent chemoradiotherapy with 5-fluorouracil or gemcitabine in locally advanced biliary tract cancer
CANCER CHEMOTHERAPY AND PHARMACOLOGY 73/1 :191-198,2014

Notch pathway activation is associated with pancreatic cancer treatment failure
PANCREATOLOGY 14/1 :48-53,2014

Clinicopathologic characteristics associated with complications and long-term outcomes of endoscopic papillectomy for adenoma
YONSEI MEDICAL JOURNAL 55/3 :644-650,2014

Duodenal adenocarcinoma following a neuroendocrine tumor in the duodenum
KOREAN JOURNAL OF INTERNAL MEDICINE 29/1 :96-100,2014

Fatal liver injury complicated by percutaneous catheter drainage after distal pancreatosplenectomy in a patient with pancreatic cancer
Korean Journal Of Hepato-Biliary-Pancreatic Surgery 18/2 :64-67,2014

Clinical usefulness of 18F-fluorodeoxyglucose-positron emission tomography in patients with locally advanced pancreatic cancer planned to undergo concurrent chemoradiation therapy
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 90/1 :126-133,2014

The Efficacy of Endoscopic Palliation of Obstructive Jaundice in Hepatocellular Carcinoma
YONSEI MEDICAL JOURNAL 55/5 :1267-1272,2014

Phase II clinical trial of ex vivo-expanded cytokine-induced killer cells therapy in advanced pancreatic cancer
CANCER IMMUNOLOGY IMMUNOTHERAPY 63/9 :939-946,2014

Gastrojejunostomy by pure natural orifice transluminal endoscopic surgery using a newly designed anastomosing metal stent in a porcine model.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 28/5 :1439-1446,2014

Validation of Group B Borderline Resectable Pancreatic Cancer: Retrospective Analysis
GUT AND LIVER 8/5 :557-562,2014

Clinical Characteristics of Long-Term Survivors of Inoperable Pancreatic Cancer An 8-Year Cohort Analysis in Korea
PANCREAS 43/7 :1022-1031,2014

Intramuscular diclofenac for the prevention of post-ERCP pancreatitis: a randomized trial
ENDOSCOPY 47/1 :33-39,2015

MUC1 selectively targets human pancreatic cancer in orthotopic nude mouse models
PLOS ONE 10/3 :0-0,2015

Full-Dose Gemcitabine is a More Effective Chemotherapeutic Agent Than 5-Fluorouracil for Concurrent Chemoradiotherapy as First-Line Treatment in Locally Advanced Pancreatic Cancer
CHEMOTHERAPY 60/3 :191-199,2015

Conventional versus Analgesia-Oriented Combination Sedation on Recovery Profiles and Satisfaction after ERCP: A Randomized Trial
PLOS ONE 10/9 :e0138422-,2015

Fluorescent-Antibody Targeting of Insulin-Like Growth Factor-1 Receptor Visualizes Metastatic Human Colon Cancer in Orthotopic Mouse Models
PLOS ONE 11/1 :e0146504-,2016

Cholecystectomy for Prevention of Recurrence after Endoscopic Clearance of Bile Duct Stones in Korea
YONSEI MEDICAL JOURNAL 57/1 :132-137,2016

Efficacy of Adjuvant Chemotherapy and Prognostic Factors for Patients with Extrahepatic Bile Duct Cancer
CHEMOTHERAPY 61/3 :152-158,2016

A Comparison of Gastrointestinal Toxicities between Intensity-Modulated Radiotherapy and Three-Dimensional Conformal Radiotherapy for Pancreatic Cancer.
GUT AND LIVER 10/2 :303-309,2016

Can metformin change the prognosis of pancreatic cancer? Retrospective study for pancreatic cancer patients with pre-existingdiabetes existingdiabetes mellitus type 2
DIGESTIVE AND LIVER DISEASE 48/4 :435-440,2016

Targeting the insulin growth factor-1 receptor with fluorescent antibodies enables high resolution imaging of human pancreatic cancer in orthotopic mouse models
ONCOTARGET 7/14 :18262-18268,2016

Statin Use and Its Impact on Survival in Pancreatic Cancer Patients Cancer Patients
MEDICINE 95/19 :e3607-,2016

Prospective Study for Comparison of Endoscopic Ultrasound-Guided Tissue Acquisition Using 25- and 22-Gauge Core Biopsy Needles in Solid Pancreatic Masses
PLOS ONE 11/5 :e0154401-,2016

현악 연주를 전공하는 음악대학 학생들의 연주불안과 연주능력과의 관계
음악교육연구 45/4 :73-91,2016

Visceral Obesity is Associated with Poor Prognosis in Pancreatic Adenocarcinoma
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL 68/2 :201-207,2016

Concomiant Statin Use Has a Favorable Effect on Gemcitabine-Erlotinib Combination Chemotherapy for Advanced Pancreatic Cancer
YONSEI MEDICAL JOURNAL 57/5 :1,124-1,130,2016

A randomized, multicenter, phase III study of gemcitabine combined with capecitabine versus gemcitabine alone as first-line chemotherapy for advanced pancreatic cancer in South Korea.
MEDICINE 96/1 :e5702-,2017

Best options for preoperative biliary drainage in patients with Klatskin tumors
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 31/1 :422-429,2017

Clinical characteristics of second primary pancreatic cancer
PLOS ONE 12/6 :e0179784-,2017

A prospective randomized study for efficacy of an uncovered double bare metal stent compared to a single bare metal stent in malignant biliary obstruction
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 31/8 :3,159-3,167,2017

Benefit of neoadjuvant concurrent chemoradiotherapy locally advanced perihilar cholangiocarcinoma
WORLD JOURNAL OF GASTROENTEROLOGY 23/18 :3,301-3,308,2017

The Significance of the Prognostic Nutritional Index for All Stages of Pancreatic Cancer
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL 69/3 :512-519,2017

Assessment of the Risk of Colorectal Cancer Survivors Developing a Second Primary Pancreatic Cancer.
GUT AND LIVER 11/5 :728-732,2017

Combination Therapy with Capecitabine and Cisplatin as Second-Line Chemotherapy for Advanced Biliary Tract Cancer
CHEMOTHERAPY 62/6 :361-366,2017

Efficacy and treatment-related adverse events of gemcitabine plus nab-paclitaxel for treatment of metastatic pancreatic cancer “in a Korean” population: A single-center cohort study
SEMINARS IN ONCOLOGY 44/ :420-427,2017

Urgent endoscopic retrograde cholangiopancreatography is not superior to early ERCP in acute biliary pancreatitis with biliary obstruction without cholangitis
PLOS ONE 13/2 :e0190835-,2018

Combined use of CEMIP and CA 19-9 enhances diagnostic accuracy for pancreatic cancer
SCIENTIFIC REPORTS 8/1 :3,383-3,389,2018

Oncologic outcomes after radical surgery for periampullary cancer in octogenarians
Korean Journal Of Hepato-Biliary-Pancreatic Surgery 22/2 :128-135,2018

Comparison of efficacy and safety between standard-dose and modified-dose FOLFIRINOX as a first-line treatment of pancreatic cancer
World Journal of Gastrointestinal Oncology 10/11 :421-430,2018

Clinical Value of Contrast-Enhanced Harmonic Endoscopic Ultrasonography in the Differential Diagnosis of Pancreatic and Gallbladder Masses.
Clinical Endoscopy 51/1 :80-88,2018

KML001, an arsenic compound, as salvage chemotherapy in refractory biliary tract cancers: A prospective study
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL 18/1 :62-66,2019

Bleeding Complications and Clinical Safety of Endoscopic Retrograde Cholangiopancreatography in Patients with Liver Cirrhosis
YONSEI MEDICAL JOURNAL 60/5 :440-445,2019

Establishment of pancreatic cancer cell lines with endoscopic ultrasound?guided biopsy via conditionally reprogrammed cell culture
CANCER MEDICINE 8/7 :3339-3348,2019

A novel lumen-apposing metal stent with an anti-reflux valve for endoscopic ultrasound-guided drainage of pseudocysts and walled-off necrosis: A pilot study
PLOS ONE 14/9 :e0221812-,2019

Skeletal Muscle Mass Predicts Poor Prognosis in Patients with Advanced Pancreatic Cancer Undergoing Second-Line FOLFIRINOX Chemotherapy
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL 71/ 7 :1100-1107,2019

소화기암 치료 후 발생하는 2차 원발성 암
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 74/4 :193-196,2019

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보도자료

[KBS 아침이 좋다] 내 몸이 보낸 경고, 시그널 : 췌장암 - 소화기내..
http://www.kbs.co.kr/2tv/sisa/goodmorning/preview/pre/index.html

[연합뉴스] "젬백스 '리아백스주', 말기 췌장암에 효과 확인" - 소화기...
http://www.yonhapnews.co.kr/bulletin/2016/09/09/0200000000AKR20160909119800017.HTML?input=1195m

[메디컬TV] 췌장암 - 소화기내과 박정엽 교수
http://www.imeditv.com/bbs/board.php?bo_table=schedule_2_1_bbs

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