김혜련
#폐암#두경부암#식도암#항암약물치료#신약치료
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학력
연세대학교 의과대학 의학과 학사 (2005)
연세대학교 의과대학 의학과 석사 (2010)
연세대학교 의과대학 의학과 박사 (2015)
연세대학교 의과대학 의학과 석사 (2010)
연세대학교 의과대학 의학과 박사 (2015)
경력
2005-2006 세브란스병원 인턴 수료
2006-2010 세브란스병원 내과 레지던트 수료
2010-2012 세브란스 병원 연세 암센터 종양내과 임상강사
2012-2016 세브란스 병원 연세 암센터 종양내과 임상조교수
2016-2019 세브란스 병원 연세 암병원 종양내과 조교수
2019-현 재 세브란스 병원 연세 암병원 종양내과 부교수
2006-2010 세브란스병원 내과 레지던트 수료
2010-2012 세브란스 병원 연세 암센터 종양내과 임상강사
2012-2016 세브란스 병원 연세 암센터 종양내과 임상조교수
2016-2019 세브란스 병원 연세 암병원 종양내과 조교수
2019-현 재 세브란스 병원 연세 암병원 종양내과 부교수
논문
1. Clinical features and treatment outcomes of advanced stage primary hepatic angiosarcoma
H. R. Kim, S. Y. Rha, S. H. Cheon, J. K. Roh, Y. N. Park & N. C. Yoo
Annals of Oncology 20: 780?787, 2009
2. Efficacy and feasibility of radiofrequency ablation for liver metastases from gastric adenocarcinoma
HYE RYUN KIM, SEONG HA CHEON, KWANG-HUN LEE, JUNG RYUN AHN,HEI-CHEUL JEUNG SUNG SOOK LEE, HYUN CHEOL CHUNG,SUNG HOON NOH, & SUN YOUNG RHA
Int. J. Hyperthermia, 2010, 1?11
3. Tension pneumopericardium after removal of pericardiocentesis drainage catheter
Hye Ryun Kim, Donghoon Choi, Joo Won Chung, Young Nam Youn, Chi Young Shim
Cardiology Journal 2009, Vol. 16, No. 5, pp. 477?.478
4. A Case of Henoch-Shonlein Purpura Caused by Rifampin
Hye Ryun Kim, Byung Hoon Park, Ji Young Sohn, Ji Ye Chung, Jung Ryun Ahn, Yoon Suk Jeung, Joo Eun Yim, Joo Won Cheung, Jiye Moon, Moo Suk Park
Tuberculosus and Respiratory Disease August, 2008 Vol 65, No 2
Dynamic changes in PD-L1 expression and CD8+ T cell infiltration in non-small cell lung cancer following chemoradiation therapy.
LUNG CANCER 136/ :30-36,2019
Hyperprogressive disease during PD-1/PD-L1 blockade in patients with non-small-cell lung cancer
ANNALS OF ONCOLOGY 30/7 :1,104-1,113,2019
Predictive factors for the development of diabetes in cancer patients treated with phosphatidylinositol 3-kinase inhibitors
CANCER CHEMOTHERAPY AND PHARMACOLOGY 84/2 :405-414,2019
A phase Ib study of the combination of afatinib and ruxolitinib in EGFR mutant NSCLC with progression on EGFR-TKIs.
LUNG CANCER 134/ :46-51,2019
Investigating the Feasibility of Targeted Next-Generation Sequencing to Guide the Treatment of Head and Neck Squamous Cell Carcinoma
CANCER RESEARCH AND TREATMENT 51/1 :300-312,2019
A Randomized, Open-Label, Phase II Study Comparing Pemetrexed Plus Cisplatin Followed by Maintenance Pemetrexed versus Pemetrexed Alone in Patients with Epidermal Growth Factor Receptor (EGFR)-Mutant Non-small Cell Lung Cancer after Failure of First
CANCER RESEARCH AND TREATMENT 51/2 :718-726,2019
Comprehensive analysis of the characteristics and treatment outcomes of patients with non-small cell lung cancer treated with anti-PD-1 therapy in real-world practice.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 145/6 :1,613-1,623,2019
YH25448, an irreversible EGFR-TKI with Potent Intracranial Activity in EGFR mutant non-smallcell lung cancer
CLINICAL CANCER RESEARCH 25/8 :2,575-2,587,2019
TRIUMPH Trial: One Small Step Could Become One Giant Leap for Precision Oncology in Head and Neck Cancer.
CANCER RESEARCH AND TREATMENT 51/1 :413-414,2019
Indoor radon exposure increases tumor mutation burden in never-smoker patients with lung adenocarcinoma.
LUNG CANCER 131/ :139-146,2019
Real-World Analysis of the Efficacy of Rebiopsy and EGFR Mutation Test of Tissue and Plasma Samples in Drug-Resistant Non-Small Cell Lung Cancer
YONSEI MEDICAL JOURNAL 60/6 :525-534,2019
Neoadjuvant therapy for thymic neoplasms reduces tumor volume per 3D-reconstructed images but does not improve the complete resection rate
PLOS ONE 14/3 :e0214291-,2019
The Ratio of Peripheral Regulatory T Cells to Lox-11 Polymorphonuclear Myeloid-derived Suppressor Cells Predicts the Early Response to Anti?PD-1 Therapy in Patients with Non?Small Cell Lung Cancer
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 199/2 :243-246,2019
Brigatinib versus Crizotinib in ALK-Positive Non?Small-Cell Lung Cancer
NEW ENGLAND JOURNAL OF MEDICINE 379/21 :2,027-2,039,2018
ERK-dependent IL-6 autocrine signaling mediates adaptive resistance to pan-PI3K inhibitor BKM120 in head and neck squamous cell carcinoma.
ONCOGENE 37/3 :377-388,2018
Survival and Functional Outcome after Treatment for Primary Base of Tongue Cancer: A Comparison of Definitive Chemoradiotherapy versus Surgery Followed by Adjuvant Radiotherapy
CANCER RESEARCH AND TREATMENT 50/4 :1,214-1,225,2018
Characteristics and Outcome of ROS1-Positive Non?Small Cell Lung Cancer Patients in Routine Clinical Practice
JOURNAL OF THORACIC ONCOLOGY 13/9 :1,373-1,382,2018
Enhancer Remodeling and MicroRNA Alterations Are Associated with Acquired Resistance to ALK Inhibitors.
CANCER RESEARCH 78/12 :3,350-3,362,2018
Establishment of a platform of non-small-cell lung cancer patient-derived xenografts with clinical and genomic annotation.
LUNG CANCER 124/ :168-178,2018
Radon Exposure-induced Genetic Variations in Lung Cancers among Never Smokers
JOURNAL OF KOREAN MEDICAL SCIENCE 33/29 :e207-e216,2018
Effects of Serum Albumin, Calcium Levels, Cancer Stage and Performance Status on Weight Loss in Parathyroid Hormone-Related Peptide Positive or Negative Patients with Cancer
대한내분비학회지 33/1 :97-104,2018
A Clinical Trial of Combination Neoadjuvant Chemotherapy and Transoral Robotic Surgery in Patients with T3 and T4 Laryngo-Hypopharyngeal Cancer
ANNALS OF SURGICAL ONCOLOGY 25/4 :864-871,2018
The Benefit of Pro Re Nata Antiemetics Provided With Guideline-Consistent Antiemetics in Delayed Nausea Control.
CANCER NURSING 41/2 :49-57,2018
Efficacy and safety of vinorelbine plus cisplatin chemotherapy for patients with recurrent and/or metastatic salivary gland cancer of the head and neck
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 40/1 :55-62,2018
Patient Experience of Symptoms and Side Effects when Treated with Osimertinib for Advanced Non-Small-Cell Lung Cancer: A Qualitative Interview Substudy.
PATIENT-PATIENT CENTERED OUTCOMES RESEARCH 10/5 :593-603,2017
Novel Genetic Associations Between Lung Cancer and Indoor Radon Exposure
Journal of Cancer Prevention 22/4 :234-240,2017
Activity and safety of AZD3759 in EGFR-mutant non-small-cell lung cancer with CNS metastases (BLOOM): a phase 1, open-label, dose-escalation and dose-expansion study.
LANCET RESPIRATORY MEDICINE 5/11 :891-902,2017
Concordance of programmed death-ligand 1 expression between primary and metastatic non-small cell lung cancer by immunohistochemistry and RNA in situ hybridization.
ONCOTARGET 8/50 :87,234-87,243,2017
Transoral robotic surgery-based therapy in patients with stage III-IV oropharyngeal squamous cell carcinoma
ORAL ONCOLOGY 75/ :16-21,2017
Architectural patterns of p16 immunohistochemical expression associated with cancer immunity and prognosis of head and neck squamous cell carcinoma
APMIS 125/11 :974-984,2017
Detection of activating and acquired resistant mutation in plasma from EGFR-mutated NSCLC patients by peptide nucleic acid (PNA) clamping-assisted fluorescence melting curve analysis.
ONCOTARGET 8/39 :65,111-65,122,2017
Next-generation sequencing reveals novel resistance mechanisms and molecular heterogeneity in EGFR-mutant non-small cell lung cancer with acquired resistance to EGFR-TKIs
LUNG CANCER 113/0 :106-114,2017
A randomized, phase II study of gefitinib alone versus nimotuzumab plus gefitinib after platinum-based chemotherapy in advanced non-small cell lung cancer (KCSG LU12-01)
ONCOTARGET 8/9 :15,943-15,951,2017
Validation of ALK/ROS1 Dual Break Apart FISH Probe probe in non-small-cell lung cancer
LUNG CANCER 111/ :79-83,2017
Open-Label, Multicenter, Phase II Study of Ceritinib in Patients With Non-Small-Cell Lung Cancer Harboring ROS1 Rearrangement.
JOURNAL OF CLINICAL ONCOLOGY 35/23 :2,613-2,618,2017
Osimertinib or Platinum-Pemetrexed in EGFR T790M-Positive Lung Cancer
NEW ENGLAND JOURNAL OF MEDICINE 376/7 :629-640,2017
Clinical trial of nintedanib in patients with recurrent or metastatic salivary gland cancer of the head and neck: A multicenter phase 2 study (Korean Cancer Study Group HN14-01)
CANCER 123/11 :1,958-1,964,2017
Significance of immune checkpoint proteins in EGFR-mutant non-small cell lung cancer
LUNG CANCER 105/ :17-22,2017
Predictive factors of early distant brain failure after gamma knife radiosurgery alone in patients with brain metastases of nonsmall-cell lung cancer
JOURNAL OF NEURO-ONCOLOGY 132/2 :333-340,2017
Co-clinical trials demonstrate predictive biomarkers for dovitinib, an FGFR inhibitor, in lung squamous cell carcinoma.
ANNALS OF ONCOLOGY 28/6 :1,250-1,259,2017
Optimal dose and volume for postoperative radiotherapy in brain oligometastases from lung cancer: a retrospective study
Radiation Oncology Journal 35/2 :153-162,2017
Prevalence and prognostic implications of psychological distress in patients with gastric cancer
BMC CANCER 17/1 :283-,2017
Establishment of a Conditional Transgenic Mouse Model Recapitulating EML4-ALK-Positive Human Non?Small Cell Lung Cancer
JOURNAL OF THORACIC ONCOLOGY 12/3 :491-500,2017
EGFR-Mediated Reactivation of MAPK Signaling Induces Acquired Resistance to GSK2118436 in BRAF V600E-Mutant NSCLC Cell Lines
MOLECULAR CANCER THERAPEUTICS 15/7 :1,627-1,636,2016
Clinical course of stage IV invasive mucinous adenocarcinoma of the lung
LUNG CANCER 102/ :82-88,2016
PD-L1 expression on immune cells, but not on tumor cells, is a favorable prognostic factor for head and neck cancer patients
SCIENTIFIC REPORTS 6/36956 :1-12,2016
Alteration status and prognostic value of MET in head and neck squamous cell carcinoma
JOURNAL OF CANCER 7/15 :2,197-2,206,2016
Longitudinal monitoring of EGFR mutations in plasma predicts outcomes of NSCLC patients treated with EGFR TKIs: Korean Lung Cancer Consortium (KLCC-12-02)
ONCOTARGET 7/6 :6,984-6,993,2016
Pilot Study of a Next-Generation Sequencing-Based Targeted Anticancer Therapy in Refractory Solid Tumors at a Korean Institution
PLOS ONE 11/4 :e0154133-,2016
Clinical outcomes in ALK-rearranged lung adenocarcinomas according to ALK fusion variants.
JOURNAL OF TRANSLATIONAL MEDICINE 14/1 :296-,2016
Induction docetaxel and S-1 followed by concomitant radiotherapy with low-dose daily cisplatin in locally advanced head and neck carcinoma
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 38/Suppl :E1,653-E1,659,2016
Next-generation sequencing reveals somatic mutations that confer exceptional response to everolimus
ONCOTARGET 7/9 :10,547-10,556,2016
A randomized phase II trial of ERCC1 and RRM1 mRNA expression-based chemotherapy versus docetaxel/carboplatin in advanced non-small cell lung cancer
CANCER CHEMOTHERAPY AND PHARMACOLOGY 77/3 :539-548,2016
Genomic profiling of lung adenocarcinoma patients reveals therapeutic targets and confers clinical benefit when standard molecular testing is negative
ONCOTARGET 7/17 :24,172-24,178,2016
ER2, a novel human anti-EGFR monoclonal antibody inhibit tumor activity in non-small cell lung cancer models
LUNG CANCER 95/ :57-64,2016
Targeted sequencing identifies genetic alterations that confer Primary resistance to EGFR tyrosine kinase inhibitor (Korean Lung Cancer Consortium)
ONCOTARGET 7/24 :36,311-36,320,2016
Efficacy and Safety of Dovitinib in Pretreated Patients With Advanced Squamous Non-Small Cell Lung Cancer With FGFR1 Amplification: A Single-Arm, Phase 2 Study
CANCER 122/19 :3,024-3,031,2016
Activation of the Met kinase confers acquired drug resistance in FGFR-targeted lung cancer therapy.
Oncogenesis 5/7 :e241-,2016
PIK3CA amplification is associated with poor prognosis among patients with curatively resected esophageal squamous cell carcinoma
ONCOTARGET 7/21 :30691-30701,2016
Clinicopathological and prognostic significance of programmed cell death ligand-1 expression in lung adenocarcinoma and its relationship with p53 status
LUNG CANCER 97/ :73-80,2016
Assessment of Adrenal Function and Health-Related Quality of Life in Advanced Gastric Cancer Patients Who Received First-Line Chemotherapy
ONCOLOGY 90/5 :248-254,2016
A Case of ALK-Rearranged Adenocarcinoma with Small Cell Carcinoma-Like Transformation and Resistance to Crizotinib
JOURNAL OF THORACIC ONCOLOGY 11/5 :e55-e58,2016
Exome sequencing reveals recurrent REV3L mutations in cisplatin-resistant squamous cell carcinoma of head and neck
SCIENTIFIC REPORTS 6/ :19552-,2016
Serum PTHrP predicts weight loss in cancer patients independent of hypercalcemia, inflammation, and tumor burden
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 101/3 :1207-1214,2016
Hippocampus-Sparing Whole-Brain Radiotherapy and Simultaneous Integrated Boost for Multiple Brain Metastases From Lung Adenocarcinoma: Early Response and Dosimetric Evaluation.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT 15/1 :122-129,2016
Pharmacogenetic analysis of advanced non-small-cell lung cancer patients treated with first-line paclitaxel and carboplatin chemotherapy
PHARMACOGENETICS AND GENOMICS 26/3 :116-125,2016
Phase II clinical and exploratory biomarker study of dacomitinib in recurrent and/or metastatic esophageal squamous cell carcinoma
ONCOTARGET 6/42 :44971-44984,2015
Reduced expression of EI24 confers resistance to gefitinib through IGF-1R signaling in PC9 NSCLC cells
LUNG CANCER 90/2 :175-181,2015
PD-1: Dual guard for immunopathology
ONCOTARGET 6/26 :21783-21784,2015
Antitumor Activity and Acquired Resistance Mechanism of Dovitinib (TKI258) in RET-Rearranged Lung Adenocarcinoma
MOLECULAR CANCER THERAPEUTICS 14/10 :2238-2248,2015
Results of a Phase II Study to Evaluate the Efficacy of Docetaxel and Carboplatin in Metastatic Malignant Melanoma Patients Who Failed First-Line Therapy Containing Dacarbazine
CANCER RESEARCH AND TREATMENT 74/4 :781-789,2015
The Clinicopathologic Features and Prognostic Impact of ALK Positivity in Patients with Resected Gastric Cancer
ANNALS OF SURGICAL ONCOLOGY 22/12 :3938-3945,2015
An open label, multicenter, phase II study of dovitinib in advanced thyroid cancer
EUROPEAN JOURNAL OF CANCER 51/12 :1588-1595,2015
The frequency and impact of FGFR1 amplification on clinical outcomes in Korean patients with small cell lung cancer
LUNG CANCER 88/3 :325-331,2015
Fibroblast growth factor receptor 1 gene amplification is associated with poor survival in patients with resected esophageal squamous cell carcinoma
ONCOTARGET 6/4 :2562-2572,2015
Phase II Clinical and Exploratory Biomarker Study of Dacomitinib in Patients with Recurrent and/or Metastatic Squamous Cell Carcinoma of Head and Neck
CLINICAL CANCER RESEARCH 21/3 :544-552,2015
Efficacy and toxicity of sunitinib in patients with metastatic renal cell carcinoma with renal insufficiency
EUROPEAN JOURNAL OF CANCER 50/4 :746-752,2014
Screening of ROS1 rearrangements in lung adenocarcinoma by immunohistochemistry and comparison with ALK rearrangements
PLOS ONE 9/Issue 7 :e103333-,2014
Identification of somatic mutations in EGFR/KRAS/ALK-negative lung adenocarcinoma in never-smokers
GENOME MEDICINE 6/18 :1-10,2014
Impact of cigarette smoking on response to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors in lung adenocarcinoma with activating EGFR mutations
LUNG CANCER 84/2 :196-202,2014
Clinical and prognostic implications of ALK and ROS1 rearrangements in never-smokers with surgically resected lung adenocarcinoma
LUNG CANCER 83/3 :389-395,2014
A prospective phase II trial of S-1 and cisplatin-based chemoradiotherapy for locoregionally advanced esophageal cancer
CANCER CHEMOTHERAPY AND PHARMACOLOGY 73/4 :665-671,2014
Prediction for response duration to epidermal growth factor receptor-tyrosine kinase inhibitors in EGFR mutated never smoker lung adenocarcinoma
LUNG CANCER 83/3 :374-382,2014
Pharmacogenetic determinants associated with sunitinib-induced toxicity and ethnic difference in Korean metastatic renal cell carcinoma patients
CANCER CHEMOTHERAPY AND PHARMACOLOGY 72/ :825-835,2013
EGFR and TTF-1 Gene Amplification in Surgically Resected Lung Adenocarcinomas: Clinicopathologic Significance and Effect on Response to EGFR-Tyrosine Kinase Inhibitors in Recurred Cases
ANNALS OF SURGICAL ONCOLOGY 20/9 :3015-3022,2013
The frequency and impact of ROS1 rearrangement on clinical outcomes in never smokers with lung adenocarcinoma
ANNALS OF ONCOLOGY 24/9 :2364-2370,2013
Multicentre phase II trial of bevacizumab combined with docetaxel？-carboplatin for the neoadjuvant treatment of triple-negative breast cancer (KCSG BR-0905)
ANNALS OF ONCOLOGY 24/6 :1485-1490,2013
Phase II study of camtobell inj. (belotecan) in combination with cisplatin in patients with previously untreated, extensive stage small cell lung cancer
LUNG CANCER 80/3 :313-318,2013
The Impact of Cigarette Smoking on the Frequency of and Qualitative Differences in KRAS Mutations in Korean Patients with Lung Adenocarcinoma
YONSEI MEDICAL JOURNAL 54/4 :865-874,2013
Role of FGF receptors as an emerging therapeutic target in lung squamous cell carcinoma.
FUTURE ONCOLOGY 9/3 :377-386,2013
Fibroblast Growth Factor Receptor 1 Gene Amplification Is Associated With Poor Survival and Cigarette Smoking Dosage in Patients With Resected Squamous Cell Lung Cancer.
JOURNAL OF CLINICAL ONCOLOGY 31/6 :731-737,2013
A phase I trial of gefitinib and nimotuzumab in patients with advanced non-small cell lung cancer (NSCLC)
LUNG CANCER 79/3 :270-275,2013
Phase II Study of Cisplatin with Irinotecan as Induction Chemotherapy Followed by Chemoradiotherapy for Unresectable Stage III Non-small Cell Lung Cancer
ANTICANCER RESEARCH 32/8 :3515-3521,2012
The efficacy and toxicity of S-1 and cisplatin as first-line chemotherapy in recurrent or metastatic head and neck squamous cell carcinoma
CANCER CHEMOTHERAPY AND PHARMACOLOGY 70/4 :539-546,2012
A phase i pharmacokinetic study of TSU-68 (a multiple tyrosine kinase inhibitor of VEGFR-2, FGF and PDFG) in combination with S-1 and oxaliplatin in metastatic colorectal cancer patients previously treated with chemotherapy
INVESTIGATIONAL NEW DRUGS 30/4 :1501-1510,2012
A Phase Ib pharmacokinetic study of the anti-angiogenic agent CKD-732 used in combination with capecitabine and oxaliplatin (XELOX) in metastatic colorectal cancer patients who progressed on irinotecan-based chemotherapy
INVESTIGATIONAL NEW DRUGS 30/ :672-680,2012
Distinct clinical features and outcomes in never-smokers with nonsmall cell lung cancer who harbor EGFR or KRAS mutations or ALK rearrangement
CANCER 118/3 :729-739,2012
Efficacy of Oxaliplatin-Based Chemotherapy in Curatively Resected Colorectal Cancer with Liver Metastasis
ONCOLOGY 81/3-4 :175-183,2011
Treatment of recurrent hepatocellular carcinoma after liver transplantation
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY 7/3 :258-269,2011
Efficacy and feasibility of radiofrequency ablation for liver metastases from gastric adenocarcinoma
International Journal Of Hyperthermia 26/4 :305-315,2010
Docetaxel versus Paclitaxel Combined with 5-FU and Leucovorin in Advanced Gastric Cancer: Combined Analysis of Two Phase II Trials
Cancer Research And Treatment 41/4 :196-204,2009
Tension pneumopericardium after removal of pericardiocentesis drainage catheter
Cardiology Journal 16/5 :477-478,2009
Clinical features and treatment outcomes of advanced stage primary hepatic angiosarcoma
Annals Of Oncology 20/4 :780-787,2009
clinical value of ezrin expression in primary osteosarcoma
Cancer Research And Treatment 41/3 :138-144,2009
Prognosis of pN3 stage gastric cancer
Cancer Research And Treatment 41/2 :73-79,2009
선천성 간경변증에서 발생한 국소결절증식양 결절 1예
대한내과학회지 76/ :s26-s30,2009
결핵 환자에서 Rifampin에 의한 Henoch-Sh？nlein Purpura 1예
Tuberculosis and Respiratory Diseases(결핵 및 호흡기질환) 65/2 :116-120,2008
Transthoracic Echocardiographic Detection, Differential Diagnosis, and Follow-Up of Esophageal Hematoma
Korean Circulation Journal 37/12 :666-670,2007
H. R. Kim, S. Y. Rha, S. H. Cheon, J. K. Roh, Y. N. Park & N. C. Yoo
Annals of Oncology 20: 780?787, 2009
2. Efficacy and feasibility of radiofrequency ablation for liver metastases from gastric adenocarcinoma
HYE RYUN KIM, SEONG HA CHEON, KWANG-HUN LEE, JUNG RYUN AHN,HEI-CHEUL JEUNG SUNG SOOK LEE, HYUN CHEOL CHUNG,SUNG HOON NOH, & SUN YOUNG RHA
Int. J. Hyperthermia, 2010, 1?11
3. Tension pneumopericardium after removal of pericardiocentesis drainage catheter
Hye Ryun Kim, Donghoon Choi, Joo Won Chung, Young Nam Youn, Chi Young Shim
Cardiology Journal 2009, Vol. 16, No. 5, pp. 477?.478
4. A Case of Henoch-Shonlein Purpura Caused by Rifampin
Hye Ryun Kim, Byung Hoon Park, Ji Young Sohn, Ji Ye Chung, Jung Ryun Ahn, Yoon Suk Jeung, Joo Eun Yim, Joo Won Cheung, Jiye Moon, Moo Suk Park
Tuberculosus and Respiratory Disease August, 2008 Vol 65, No 2
Dynamic changes in PD-L1 expression and CD8+ T cell infiltration in non-small cell lung cancer following chemoradiation therapy.
LUNG CANCER 136/ :30-36,2019
Hyperprogressive disease during PD-1/PD-L1 blockade in patients with non-small-cell lung cancer
ANNALS OF ONCOLOGY 30/7 :1,104-1,113,2019
Predictive factors for the development of diabetes in cancer patients treated with phosphatidylinositol 3-kinase inhibitors
CANCER CHEMOTHERAPY AND PHARMACOLOGY 84/2 :405-414,2019
A phase Ib study of the combination of afatinib and ruxolitinib in EGFR mutant NSCLC with progression on EGFR-TKIs.
LUNG CANCER 134/ :46-51,2019
Investigating the Feasibility of Targeted Next-Generation Sequencing to Guide the Treatment of Head and Neck Squamous Cell Carcinoma
CANCER RESEARCH AND TREATMENT 51/1 :300-312,2019
A Randomized, Open-Label, Phase II Study Comparing Pemetrexed Plus Cisplatin Followed by Maintenance Pemetrexed versus Pemetrexed Alone in Patients with Epidermal Growth Factor Receptor (EGFR)-Mutant Non-small Cell Lung Cancer after Failure of First
CANCER RESEARCH AND TREATMENT 51/2 :718-726,2019
Comprehensive analysis of the characteristics and treatment outcomes of patients with non-small cell lung cancer treated with anti-PD-1 therapy in real-world practice.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 145/6 :1,613-1,623,2019
YH25448, an irreversible EGFR-TKI with Potent Intracranial Activity in EGFR mutant non-smallcell lung cancer
CLINICAL CANCER RESEARCH 25/8 :2,575-2,587,2019
TRIUMPH Trial: One Small Step Could Become One Giant Leap for Precision Oncology in Head and Neck Cancer.
CANCER RESEARCH AND TREATMENT 51/1 :413-414,2019
Indoor radon exposure increases tumor mutation burden in never-smoker patients with lung adenocarcinoma.
LUNG CANCER 131/ :139-146,2019
Real-World Analysis of the Efficacy of Rebiopsy and EGFR Mutation Test of Tissue and Plasma Samples in Drug-Resistant Non-Small Cell Lung Cancer
YONSEI MEDICAL JOURNAL 60/6 :525-534,2019
Neoadjuvant therapy for thymic neoplasms reduces tumor volume per 3D-reconstructed images but does not improve the complete resection rate
PLOS ONE 14/3 :e0214291-,2019
The Ratio of Peripheral Regulatory T Cells to Lox-11 Polymorphonuclear Myeloid-derived Suppressor Cells Predicts the Early Response to Anti?PD-1 Therapy in Patients with Non?Small Cell Lung Cancer
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 199/2 :243-246,2019
Brigatinib versus Crizotinib in ALK-Positive Non?Small-Cell Lung Cancer
NEW ENGLAND JOURNAL OF MEDICINE 379/21 :2,027-2,039,2018
ERK-dependent IL-6 autocrine signaling mediates adaptive resistance to pan-PI3K inhibitor BKM120 in head and neck squamous cell carcinoma.
ONCOGENE 37/3 :377-388,2018
Survival and Functional Outcome after Treatment for Primary Base of Tongue Cancer: A Comparison of Definitive Chemoradiotherapy versus Surgery Followed by Adjuvant Radiotherapy
CANCER RESEARCH AND TREATMENT 50/4 :1,214-1,225,2018
Characteristics and Outcome of ROS1-Positive Non?Small Cell Lung Cancer Patients in Routine Clinical Practice
JOURNAL OF THORACIC ONCOLOGY 13/9 :1,373-1,382,2018
Enhancer Remodeling and MicroRNA Alterations Are Associated with Acquired Resistance to ALK Inhibitors.
CANCER RESEARCH 78/12 :3,350-3,362,2018
Establishment of a platform of non-small-cell lung cancer patient-derived xenografts with clinical and genomic annotation.
LUNG CANCER 124/ :168-178,2018
Radon Exposure-induced Genetic Variations in Lung Cancers among Never Smokers
JOURNAL OF KOREAN MEDICAL SCIENCE 33/29 :e207-e216,2018
Effects of Serum Albumin, Calcium Levels, Cancer Stage and Performance Status on Weight Loss in Parathyroid Hormone-Related Peptide Positive or Negative Patients with Cancer
대한내분비학회지 33/1 :97-104,2018
A Clinical Trial of Combination Neoadjuvant Chemotherapy and Transoral Robotic Surgery in Patients with T3 and T4 Laryngo-Hypopharyngeal Cancer
ANNALS OF SURGICAL ONCOLOGY 25/4 :864-871,2018
The Benefit of Pro Re Nata Antiemetics Provided With Guideline-Consistent Antiemetics in Delayed Nausea Control.
CANCER NURSING 41/2 :49-57,2018
Efficacy and safety of vinorelbine plus cisplatin chemotherapy for patients with recurrent and/or metastatic salivary gland cancer of the head and neck
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 40/1 :55-62,2018
Patient Experience of Symptoms and Side Effects when Treated with Osimertinib for Advanced Non-Small-Cell Lung Cancer: A Qualitative Interview Substudy.
PATIENT-PATIENT CENTERED OUTCOMES RESEARCH 10/5 :593-603,2017
Novel Genetic Associations Between Lung Cancer and Indoor Radon Exposure
Journal of Cancer Prevention 22/4 :234-240,2017
Activity and safety of AZD3759 in EGFR-mutant non-small-cell lung cancer with CNS metastases (BLOOM): a phase 1, open-label, dose-escalation and dose-expansion study.
LANCET RESPIRATORY MEDICINE 5/11 :891-902,2017
Concordance of programmed death-ligand 1 expression between primary and metastatic non-small cell lung cancer by immunohistochemistry and RNA in situ hybridization.
ONCOTARGET 8/50 :87,234-87,243,2017
Transoral robotic surgery-based therapy in patients with stage III-IV oropharyngeal squamous cell carcinoma
ORAL ONCOLOGY 75/ :16-21,2017
Architectural patterns of p16 immunohistochemical expression associated with cancer immunity and prognosis of head and neck squamous cell carcinoma
APMIS 125/11 :974-984,2017
Detection of activating and acquired resistant mutation in plasma from EGFR-mutated NSCLC patients by peptide nucleic acid (PNA) clamping-assisted fluorescence melting curve analysis.
ONCOTARGET 8/39 :65,111-65,122,2017
Next-generation sequencing reveals novel resistance mechanisms and molecular heterogeneity in EGFR-mutant non-small cell lung cancer with acquired resistance to EGFR-TKIs
LUNG CANCER 113/0 :106-114,2017
A randomized, phase II study of gefitinib alone versus nimotuzumab plus gefitinib after platinum-based chemotherapy in advanced non-small cell lung cancer (KCSG LU12-01)
ONCOTARGET 8/9 :15,943-15,951,2017
Validation of ALK/ROS1 Dual Break Apart FISH Probe probe in non-small-cell lung cancer
LUNG CANCER 111/ :79-83,2017
Open-Label, Multicenter, Phase II Study of Ceritinib in Patients With Non-Small-Cell Lung Cancer Harboring ROS1 Rearrangement.
JOURNAL OF CLINICAL ONCOLOGY 35/23 :2,613-2,618,2017
Osimertinib or Platinum-Pemetrexed in EGFR T790M-Positive Lung Cancer
NEW ENGLAND JOURNAL OF MEDICINE 376/7 :629-640,2017
Clinical trial of nintedanib in patients with recurrent or metastatic salivary gland cancer of the head and neck: A multicenter phase 2 study (Korean Cancer Study Group HN14-01)
CANCER 123/11 :1,958-1,964,2017
Significance of immune checkpoint proteins in EGFR-mutant non-small cell lung cancer
LUNG CANCER 105/ :17-22,2017
Predictive factors of early distant brain failure after gamma knife radiosurgery alone in patients with brain metastases of nonsmall-cell lung cancer
JOURNAL OF NEURO-ONCOLOGY 132/2 :333-340,2017
Co-clinical trials demonstrate predictive biomarkers for dovitinib, an FGFR inhibitor, in lung squamous cell carcinoma.
ANNALS OF ONCOLOGY 28/6 :1,250-1,259,2017
Optimal dose and volume for postoperative radiotherapy in brain oligometastases from lung cancer: a retrospective study
Radiation Oncology Journal 35/2 :153-162,2017
Prevalence and prognostic implications of psychological distress in patients with gastric cancer
BMC CANCER 17/1 :283-,2017
Establishment of a Conditional Transgenic Mouse Model Recapitulating EML4-ALK-Positive Human Non?Small Cell Lung Cancer
JOURNAL OF THORACIC ONCOLOGY 12/3 :491-500,2017
EGFR-Mediated Reactivation of MAPK Signaling Induces Acquired Resistance to GSK2118436 in BRAF V600E-Mutant NSCLC Cell Lines
MOLECULAR CANCER THERAPEUTICS 15/7 :1,627-1,636,2016
Clinical course of stage IV invasive mucinous adenocarcinoma of the lung
LUNG CANCER 102/ :82-88,2016
PD-L1 expression on immune cells, but not on tumor cells, is a favorable prognostic factor for head and neck cancer patients
SCIENTIFIC REPORTS 6/36956 :1-12,2016
Alteration status and prognostic value of MET in head and neck squamous cell carcinoma
JOURNAL OF CANCER 7/15 :2,197-2,206,2016
Longitudinal monitoring of EGFR mutations in plasma predicts outcomes of NSCLC patients treated with EGFR TKIs: Korean Lung Cancer Consortium (KLCC-12-02)
ONCOTARGET 7/6 :6,984-6,993,2016
Pilot Study of a Next-Generation Sequencing-Based Targeted Anticancer Therapy in Refractory Solid Tumors at a Korean Institution
PLOS ONE 11/4 :e0154133-,2016
Clinical outcomes in ALK-rearranged lung adenocarcinomas according to ALK fusion variants.
JOURNAL OF TRANSLATIONAL MEDICINE 14/1 :296-,2016
Induction docetaxel and S-1 followed by concomitant radiotherapy with low-dose daily cisplatin in locally advanced head and neck carcinoma
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 38/Suppl :E1,653-E1,659,2016
Next-generation sequencing reveals somatic mutations that confer exceptional response to everolimus
ONCOTARGET 7/9 :10,547-10,556,2016
A randomized phase II trial of ERCC1 and RRM1 mRNA expression-based chemotherapy versus docetaxel/carboplatin in advanced non-small cell lung cancer
CANCER CHEMOTHERAPY AND PHARMACOLOGY 77/3 :539-548,2016
Genomic profiling of lung adenocarcinoma patients reveals therapeutic targets and confers clinical benefit when standard molecular testing is negative
ONCOTARGET 7/17 :24,172-24,178,2016
ER2, a novel human anti-EGFR monoclonal antibody inhibit tumor activity in non-small cell lung cancer models
LUNG CANCER 95/ :57-64,2016
Targeted sequencing identifies genetic alterations that confer Primary resistance to EGFR tyrosine kinase inhibitor (Korean Lung Cancer Consortium)
ONCOTARGET 7/24 :36,311-36,320,2016
Efficacy and Safety of Dovitinib in Pretreated Patients With Advanced Squamous Non-Small Cell Lung Cancer With FGFR1 Amplification: A Single-Arm, Phase 2 Study
CANCER 122/19 :3,024-3,031,2016
Activation of the Met kinase confers acquired drug resistance in FGFR-targeted lung cancer therapy.
Oncogenesis 5/7 :e241-,2016
PIK3CA amplification is associated with poor prognosis among patients with curatively resected esophageal squamous cell carcinoma
ONCOTARGET 7/21 :30691-30701,2016
Clinicopathological and prognostic significance of programmed cell death ligand-1 expression in lung adenocarcinoma and its relationship with p53 status
LUNG CANCER 97/ :73-80,2016
Assessment of Adrenal Function and Health-Related Quality of Life in Advanced Gastric Cancer Patients Who Received First-Line Chemotherapy
ONCOLOGY 90/5 :248-254,2016
A Case of ALK-Rearranged Adenocarcinoma with Small Cell Carcinoma-Like Transformation and Resistance to Crizotinib
JOURNAL OF THORACIC ONCOLOGY 11/5 :e55-e58,2016
Exome sequencing reveals recurrent REV3L mutations in cisplatin-resistant squamous cell carcinoma of head and neck
SCIENTIFIC REPORTS 6/ :19552-,2016
Serum PTHrP predicts weight loss in cancer patients independent of hypercalcemia, inflammation, and tumor burden
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 101/3 :1207-1214,2016
Hippocampus-Sparing Whole-Brain Radiotherapy and Simultaneous Integrated Boost for Multiple Brain Metastases From Lung Adenocarcinoma: Early Response and Dosimetric Evaluation.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT 15/1 :122-129,2016
Pharmacogenetic analysis of advanced non-small-cell lung cancer patients treated with first-line paclitaxel and carboplatin chemotherapy
PHARMACOGENETICS AND GENOMICS 26/3 :116-125,2016
Phase II clinical and exploratory biomarker study of dacomitinib in recurrent and/or metastatic esophageal squamous cell carcinoma
ONCOTARGET 6/42 :44971-44984,2015
Reduced expression of EI24 confers resistance to gefitinib through IGF-1R signaling in PC9 NSCLC cells
LUNG CANCER 90/2 :175-181,2015
PD-1: Dual guard for immunopathology
ONCOTARGET 6/26 :21783-21784,2015
Antitumor Activity and Acquired Resistance Mechanism of Dovitinib (TKI258) in RET-Rearranged Lung Adenocarcinoma
MOLECULAR CANCER THERAPEUTICS 14/10 :2238-2248,2015
Results of a Phase II Study to Evaluate the Efficacy of Docetaxel and Carboplatin in Metastatic Malignant Melanoma Patients Who Failed First-Line Therapy Containing Dacarbazine
CANCER RESEARCH AND TREATMENT 74/4 :781-789,2015
The Clinicopathologic Features and Prognostic Impact of ALK Positivity in Patients with Resected Gastric Cancer
ANNALS OF SURGICAL ONCOLOGY 22/12 :3938-3945,2015
An open label, multicenter, phase II study of dovitinib in advanced thyroid cancer
EUROPEAN JOURNAL OF CANCER 51/12 :1588-1595,2015
The frequency and impact of FGFR1 amplification on clinical outcomes in Korean patients with small cell lung cancer
LUNG CANCER 88/3 :325-331,2015
Fibroblast growth factor receptor 1 gene amplification is associated with poor survival in patients with resected esophageal squamous cell carcinoma
ONCOTARGET 6/4 :2562-2572,2015
Phase II Clinical and Exploratory Biomarker Study of Dacomitinib in Patients with Recurrent and/or Metastatic Squamous Cell Carcinoma of Head and Neck
CLINICAL CANCER RESEARCH 21/3 :544-552,2015
Efficacy and toxicity of sunitinib in patients with metastatic renal cell carcinoma with renal insufficiency
EUROPEAN JOURNAL OF CANCER 50/4 :746-752,2014
Screening of ROS1 rearrangements in lung adenocarcinoma by immunohistochemistry and comparison with ALK rearrangements
PLOS ONE 9/Issue 7 :e103333-,2014
Identification of somatic mutations in EGFR/KRAS/ALK-negative lung adenocarcinoma in never-smokers
GENOME MEDICINE 6/18 :1-10,2014
Impact of cigarette smoking on response to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors in lung adenocarcinoma with activating EGFR mutations
LUNG CANCER 84/2 :196-202,2014
Clinical and prognostic implications of ALK and ROS1 rearrangements in never-smokers with surgically resected lung adenocarcinoma
LUNG CANCER 83/3 :389-395,2014
A prospective phase II trial of S-1 and cisplatin-based chemoradiotherapy for locoregionally advanced esophageal cancer
CANCER CHEMOTHERAPY AND PHARMACOLOGY 73/4 :665-671,2014
Prediction for response duration to epidermal growth factor receptor-tyrosine kinase inhibitors in EGFR mutated never smoker lung adenocarcinoma
LUNG CANCER 83/3 :374-382,2014
Pharmacogenetic determinants associated with sunitinib-induced toxicity and ethnic difference in Korean metastatic renal cell carcinoma patients
CANCER CHEMOTHERAPY AND PHARMACOLOGY 72/ :825-835,2013
EGFR and TTF-1 Gene Amplification in Surgically Resected Lung Adenocarcinomas: Clinicopathologic Significance and Effect on Response to EGFR-Tyrosine Kinase Inhibitors in Recurred Cases
ANNALS OF SURGICAL ONCOLOGY 20/9 :3015-3022,2013
The frequency and impact of ROS1 rearrangement on clinical outcomes in never smokers with lung adenocarcinoma
ANNALS OF ONCOLOGY 24/9 :2364-2370,2013
Multicentre phase II trial of bevacizumab combined with docetaxel？-carboplatin for the neoadjuvant treatment of triple-negative breast cancer (KCSG BR-0905)
ANNALS OF ONCOLOGY 24/6 :1485-1490,2013
Phase II study of camtobell inj. (belotecan) in combination with cisplatin in patients with previously untreated, extensive stage small cell lung cancer
LUNG CANCER 80/3 :313-318,2013
The Impact of Cigarette Smoking on the Frequency of and Qualitative Differences in KRAS Mutations in Korean Patients with Lung Adenocarcinoma
YONSEI MEDICAL JOURNAL 54/4 :865-874,2013
Role of FGF receptors as an emerging therapeutic target in lung squamous cell carcinoma.
FUTURE ONCOLOGY 9/3 :377-386,2013
Fibroblast Growth Factor Receptor 1 Gene Amplification Is Associated With Poor Survival and Cigarette Smoking Dosage in Patients With Resected Squamous Cell Lung Cancer.
JOURNAL OF CLINICAL ONCOLOGY 31/6 :731-737,2013
A phase I trial of gefitinib and nimotuzumab in patients with advanced non-small cell lung cancer (NSCLC)
LUNG CANCER 79/3 :270-275,2013
Phase II Study of Cisplatin with Irinotecan as Induction Chemotherapy Followed by Chemoradiotherapy for Unresectable Stage III Non-small Cell Lung Cancer
ANTICANCER RESEARCH 32/8 :3515-3521,2012
The efficacy and toxicity of S-1 and cisplatin as first-line chemotherapy in recurrent or metastatic head and neck squamous cell carcinoma
CANCER CHEMOTHERAPY AND PHARMACOLOGY 70/4 :539-546,2012
A phase i pharmacokinetic study of TSU-68 (a multiple tyrosine kinase inhibitor of VEGFR-2, FGF and PDFG) in combination with S-1 and oxaliplatin in metastatic colorectal cancer patients previously treated with chemotherapy
INVESTIGATIONAL NEW DRUGS 30/4 :1501-1510,2012
A Phase Ib pharmacokinetic study of the anti-angiogenic agent CKD-732 used in combination with capecitabine and oxaliplatin (XELOX) in metastatic colorectal cancer patients who progressed on irinotecan-based chemotherapy
INVESTIGATIONAL NEW DRUGS 30/ :672-680,2012
Distinct clinical features and outcomes in never-smokers with nonsmall cell lung cancer who harbor EGFR or KRAS mutations or ALK rearrangement
CANCER 118/3 :729-739,2012
Efficacy of Oxaliplatin-Based Chemotherapy in Curatively Resected Colorectal Cancer with Liver Metastasis
ONCOLOGY 81/3-4 :175-183,2011
Treatment of recurrent hepatocellular carcinoma after liver transplantation
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY 7/3 :258-269,2011
Efficacy and feasibility of radiofrequency ablation for liver metastases from gastric adenocarcinoma
International Journal Of Hyperthermia 26/4 :305-315,2010
Docetaxel versus Paclitaxel Combined with 5-FU and Leucovorin in Advanced Gastric Cancer: Combined Analysis of Two Phase II Trials
Cancer Research And Treatment 41/4 :196-204,2009
Tension pneumopericardium after removal of pericardiocentesis drainage catheter
Cardiology Journal 16/5 :477-478,2009
Clinical features and treatment outcomes of advanced stage primary hepatic angiosarcoma
Annals Of Oncology 20/4 :780-787,2009
clinical value of ezrin expression in primary osteosarcoma
Cancer Research And Treatment 41/3 :138-144,2009
Prognosis of pN3 stage gastric cancer
Cancer Research And Treatment 41/2 :73-79,2009
선천성 간경변증에서 발생한 국소결절증식양 결절 1예
대한내과학회지 76/ :s26-s30,2009
결핵 환자에서 Rifampin에 의한 Henoch-Sh？nlein Purpura 1예
Tuberculosis and Respiratory Diseases(결핵 및 호흡기질환) 65/2 :116-120,2008
Transthoracic Echocardiographic Detection, Differential Diagnosis, and Follow-Up of Esophageal Hematoma
Korean Circulation Journal 37/12 :666-670,2007
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