강한성

  #유방암의 진단 및 수술적 치료#유방암의 새로운 치료법 개발을 위한 유전자 연구

학력

1983-03~1989-02 서울대학교 의과대학 의학과 대졸(의대)
1993-03~1998-02 서울대학교 의과대학원 의학과 대학원졸(석사)
1998-03~2000-08 서울대학교 의과대학원 보건과학과 대학원졸(박사)

경력

1989-03~1990-02 서울대학교병원 인턴
1990-03~1994-02 서울대학교병원 레지던트
1997-05~1998-04 서울대학교병원 전임의
1998-05~1999-12 서울시립보라매병원 임상교수
2000-01~2000-09 서울시립보라매병원 임상교수
2000-10~2001-05 국립암센터 유방암센터 의사직
2001-05~2015-02 국립암센터 유방내분비암연구과 선임연구원
2001-05~현재 국립암센터 유방암센터 전문의
2002-01~2004-09 국립암센터 응급실 실장
2004-09~2005-08 미국 NCI 해외연수
2009-02~2012-08 국립암센터 유방암센터 센터장
2014-10~2015-02 국립암센터 유방내분비암연구과 과장
2019-02~현재 국립암센터 외과 의사직

논문

2020 SCI-E Exon splicing analysis of intronic variants in multigene cancer panel testing for hereditary breast/ovarian cancer: CANCER SCIENCE. Online:Published (4.966)

2020 기타 Comparison of clinical outcomes between sentinel lymph node biopsy and axillary lymph node dissection in a single-center Z0011-eligible breast cancer cohort: Korean Journal of Clinical Oncology. 16(1):18~24 ()

2020 SCI-E Role of aldehyde dehydrogenases, alcohol dehydrogenase 1B genotype, alcohol consumption, and their combination in breast cancer in East-Asian women: SCIENTIFIC REPORTS. 10(1):6564~ (3.998)

2020 SCI-E Comparing the Characteristics and Outcomes of Male and Female Breast Cancer Patients in Korea: Korea Central Cancer Registry: CANCER RESEARCH AND TREATMENT. 52(3):739~746 (3.761)

2019 SCI The Sentinel Lymph Node Biopsy Using Indocyanine Green Fluorescence Plus Radioisotope Method Compared With the Radioisotope-Only Method for Breast Cancer Patients After Neoadjuvant Chemotherapy: A Prospective, Randomized, Open-Label, Single-Center Phase 2 Trial: ANNALS OF SURGICAL ONCOLOGY. 26(8):2409~2416 (3.681)

2019 기타 Radiaion-induced sarcoma after breast cancer treatment: Two cases with different prognosis: 대한유방검진학회지. 16:25~31 (0)

2019 SCI-E Interaction Effect Between Breast Density and Reproductive Factors on Breast Cancer Risk in Korean Population: EUROPEAN JOURNAL OF CANCER PREVENTION. 24(1):26~32 (2.33)

2018 SCI-E Different Patterns of Risk Reducing Decisions in Affected or Unaffected BRCA Pathogenic Variant Carriers: CANCER RESEARCH AND TREATMENT. 51(1):280~288 (3.23)

2018 SCI-E Predicting Response to Neoadjuvant Chemotherapy in Patients With Breast Cancer: combined Statistical Modeling Using Clinicopathological Factors and FDG PET/CT Texture Parameters: clinical nuclear medicine. 44(1):21~29 (6.309)

2018 SCI-E Magnetic Resonance Imaging (MRI) Assessment of Residual Breast Cancer After Neoadjuvant Chemotherapy: Relevance to Tumor Subtypes and MRI Interpretation Threshold.: Clinical breast cancer. 18(6):459~467 (2.703)

2018 SCI Prognostic impact of skeletal muscle volume derived from crosssectional computed tomography images in breast cancer: BREAST CANCER RESEARCH AND TREATMENT. 172(2):425~436 (3.605)

2017 SCI-E Prognostic Impact of Elective Supraclavicular Nodal Irradiation for Patients with N1 Breast Cancer after Lumpectomy and Anthracycline plus Taxane-based Chemotherapy (KROG 1418): A Multicenter Case-Controlled Study: Cancer Research and Treatment. 49(4):970~980 (3.772)

2017 SCI-E CKAP2 (cytoskeleton-associated protein2) is a new prognostic marker in HER2-negative luminal type breast cancer: PLOS ONE. 12(8):e0182107~e0182107 (2.806)

2017 SCI-E A magnetic resonance image-guided breast needle intervention robot system: overview and design considerations: International Journal of Computer Assisted Radiology and Surgery. 12:1319~1331 (1.863)

2016 SCI-E Optimal radiation dose for patients with one to three lymph node positive breast cancer following breast-conserving surgery and anthracycline plus taxane-based chemotherapy: A retrospective multicenter analysis (KROG 1418): Oncotarget. 8(1):1796~1804 (5.008)

2016 SSCI Three-Year Prospective Cohort Study of Factors Associated with Return to Work After Breast Cancer Diagnosis.: Journal of Occup Rehabilitation. Online:Published (1.644)

2016 SCI-E The Significance of Serum HER2 Levels at Diagnosis on Intrinsic Subtype-Specific Outcome of Operable Breast Cancer Patients: PLOS ONE. 11(10):e0163370~e0163370 (3.057)
2016 SCI-E Identification of Prognostic Risk Factors for Transient and Persistent Lymphedema after Multimodal Treatment for Breast Cancer: Cancer Research and Treatment. 48(4):1330~1337 (4.245)

2015 SCI-E Effect of Time Interval between Breast-conserving Surgery and Radiation Therapy on Outcomes of Node-positive Breast Cancer Patients Treated with Adjuvant Doxorubicin/Cyclophosphamide followed by Taxane: Cancer research and treatment. 48(2):483~490 (3.318)

2015 SCI-E Prognostic Implications of Tumor-Infiltrating Lymphocytes in Association With Programmed Death Ligand 1 Expression in Early-Stage Breast Cancer: Clinical Breast Cancer. 16(1):51~58 (2.107)

2015 SCI-E Identification of Risk Factors for Locoregional Recurrence in Breast Cancer Patients with Nodal Stage N0 and N1: Who Could Benefit from Post-Mastectomy Radiotherapy?: PLoS ONE. 10(12):e0145463~e0145463 (3.234)

2015 SCI The Value of Ki67 in Very Young Women with Hormone Receptor-Positive Breast Cancer: Retrospective Analysis of 9,321 Korean Women.: Annals of surgical oncology. 22(11):3481~3488 (3.93)

2015 SCI-E Breast Cancer-Related Lymphedema after Neoadjuvant Chemotherapy: Cancer research and treatment. 47(3):416~423 (3.318)

2014 SCI High Volumetric Breast Density Predicts Risk for Breast Cancer in Postmenopausal, but not Premenopausal, Korean Women: Annals of surgical oncology. 21(13):4124~4132 (3.943)

2014 SCI Treatment factors affecting breast cancer-related lymphedema after systemic chemotherapy and radiotherapy in stage II/III breast cancer patients: Breast cancer research and treatment. 148(1):91~98 (4.198)

2014 SCI Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1: Nature genetics. 46(8):886~890 (29.648)

2014 SCI MicroRNA signature for HER2-positive breast and gastric cancer.: Anticancer research. 34(7):3807~3810 (1.872)

2014 SCI Comparison of Sentinel Lymph Node Biopsy Guided by the Multimodal Method of Indocyanine Green Fluorescence, Radioisotope, and Blue Dye Versus the Radioisotope Method in Breast Cancer: A Randomized Controlled Trial: Annals of Surgical Oncology. 21(4):1254~1259 (3.943)

2014 SCI-E Phase II randomized trial of neoadjuvant metformin plus letrozole versus placebo plus letrozole for estrogen receptor positive postmenopausal breast cancer (METEOR): BMC cancer. 14:170~174 (3.319)

2014 SCI-E Association of Polymorphisms and Haplotypes in the Insulin-Like Growth Factor 1 Receptor (IGF1R) Gene with the Risk of Breast Cancer in Korean Women.: PLOS One. 9(1):e84532~e84532 (3.534)

2013 SCI Phase 2 trial of accelerated, hypofractionated whole-breast irradiation of 39 Gy in 13 fractions followed by a tumor bed boost sequentially delivering 9 Gy in 3 fractions in early-stage breast cancer: International Journal of Radiation Oncology Biology Physics. 87(5):1037~1042 (4.524)

2013 SCI DNA Methylation of MAPK Signal-inhibiting Genes in Papillary Thyroid Carcinoma: AntiCancer Research. 33(11):4833~4839 (1.713)

2013 SCI-E Nuclear-encoded mitochondrial MTO1 and MRPL41 are regulated in an opposite epigenetic mode based on estrogen receptor status in breast cancer.: BMC cancer. 13(1):502~502 (3.333)

2013 SCI A Model to Estimate the Risk of Breast Cancer-Related Lymphedema: Combinations of Treatment-Related Factors of the Number of Dissected Axillary Nodes, Adjuvant Chemotherapy, and Radiation Therapy: International Journal of Radiation Oncology, Biology, Physics. 86(3):498~503 (4.524)

2013 기타 MALDI MS Profiles Distinguish ER-Negative Breast Cancers from Lung Adenocarcinoma: Journal of Proteomics and Bioinformatics. 2013:S6~S6 (0)

2013 SCI-E A Case of Locally Advanced Breast Cancer Complicated by Pulmonary Tumor Thrombotic Microangiopathy: Cancer Research and Treatment. 44(4):267~270 (0)

2012 SCI-E Prognostic implication of thyroglobulin and quantified whole body scan after initial radioiodine therapy on early prediction of ablation and clinical response for the patients with differentiated thyroid cancer: Annals of Nuclear Medicine. 26(10):777~786 (1.502)

2012 SCI-E Stage-to-stage Comparison of Neoadjuvant Chemotherapy Versus Adjuvant Chemotherapy in Pathological Lymph Node Positive Breast Cancer Patients: Japanese Journal of Clinical Oncology. 42(11):995~1001 (1.783)

2012 SCI Predicting Nonsentinel Lymph Node Metastasis Using Lymphoscintigraphy in Patients with Breast Cancer: The Journal of Nuclear Medicine. 53(11):1693~1700 (6.381)

2012 SCI Resumption or persistence of menstruation after cytotoxic chemotherapy is a prognostic factor for poor disease-free survival in premenopausal patients with early breast cancer: Annals of Oncology. 23(9):2283~2289 (6.425)

2012 SCI Salinomycin, a p-glycoprotein inhibitor, sensitizes radiation-treated cancer cells by increasing DNA damage and inducing G2 arrest: Investigational New Drugs. 30(4):1311~1318 (3.357)

2012 SCI Metaplastic breast cancer: clinicopathological features and its prognosis: Journal of clinical pathology. 65(5):441~446 (2.306)

2012 SCI Phase II trial of preoperative paclitaxel, gemcitabine, and trastuzumab combination therapy in HER2 positive stage II/III breast cancer: The Korean Cancer Study Group BR 07-01: Breast Cancer Res Treat. 132(2):589~600 (4.431)

2012 SCI Salinomycin sensitizes antimitotic drugs-treated cancer cells by increasing apoptosis via the prevention of G2 arrest: Biochemical and Biophysical Research Communications. 481(1):98~103 (2.484)

2012 SCI lack of any association between functionally significant CYP2D6 polymorphisms and clinical outcomes in early breast cancer patients receiving adjuvant tamoxifen treatment: Breast cancer research and treatment. 131(2):455~461 (4.431)

2011 SCI A phase Ib study of preoperative lapatinib, paclitaxel, and gemcitabine combination therapy in women with HER2 positive early breast cancer: Investigational New Drugs. 30(5):1972~1977 (3.357)

2011 SCI Locoregional recurrence of breast cancer in patients treated with breast conservation surgery and radiotherapy following neoadjuvant chemotherapy.: International Journal of Radiation Oncology*Biology*Physics. 81(5):e697~e705 (4.503)

2011 SCI Outcomes of Positron Emission Tomography-Staged Clinical N3 Breast Cancer Treated with Neoadjuvant Chemotherapy, Surgery, and Radiotherapy.: Int J Radiat Oncol Biol Phys. 81(5):e689~e695 (4.503)

2011 SCI-E Locoregional Recurrence of Breast Conserving Surgery after Preoperative Chemotherapy in Korean Women with Locally Advanced Breast Cancer: Journal of Breast Cancer. 14(4):289~295 (0.179)

2011 SCI-E Protein and lipid MALDI profiles classify breast cancers according to the intrinsic subtype.: BMC cancer. 11:465~465 (3.153)

2011 SCI Differential methylation hybridization profiling identifies involvement of STAT1-mediated pathways in breast cancer: International Journal of Oncology. 39:955~963 (2.571)

2011 SCI Social support and depressive mood 1 year after diagnosis of breast cancer compared with the general female population: a prospective cohort study.: Supportive care in cancer. 19(9):1379~1392 (2.058)

2011 SCI Clinicopathological parameters and biological markers predicting non-sentinel node metastasis in sentinel node-positive breast cancer patients: Oncology Reports. 25(4):1063~1071 (1.686)

2011 SCI Adipokines, insulin resistance, metabolic syndrome, and breast cancer recurrence: a cohort study: BREAST CANCER RESEARCH. 13(2):r34~r34 (5.785)

2011 SCI Accumulation of p53 determined by immunohistochemistry as a prognostic marker in node negative breast cancer; analysis according to st gallen consensus and intrinsic subtypes.: Journal of Surgical Oncology. 103(3):207~211 (2.428)

2011 SCI-E Randomized Piolt test of a Simultaneous Stage-matched Exercise and Diet Interventions for Breast Cancer Survivors: Oncology Nursing Forum. 38(2):e97~e106 (1.779)

2011 SCI Salinomycin sensitizes cancer cells to the effects of doxorubicin and etoposide treatment by increasing DNA damage and reducing p21 protein: British Journal of Pharmacology. 162(3):773~784 (4.925)

2011 SCI Health-Related Quality of Life in Survivors With Breast Cancer 1 Year After Diagosis Compared With the General Population A Prospective Cohort Study: Annals of Surgery. 253(1):101~108 (7.474)

2010 SCI-E Charlson Comorbidity Index as a Predictor of Long-Term Survival after Surgery for Breast Cancer: A Nationwide Retrospective Cohort Study in South Korea: Journal of Breast Cancer. 13(4):409~417 (0.329)

2010 SCI-E The invasive lobular carcinoma as a prototype luminal A breast cancer: a retrospective cohort study.: BMC cancer. 10(1):664~664 (2.736)

2010 SCI Hypomethylation of the interleukin-10 gene in breast cancer tissues: Breast. 19(6):484~488 (2.087)

2010 SCI Methylation patterns of genes coding for drug-metabolizing enzymes in tamoxifen-resistant breast cancer tissues: Journal of Molecular medicine. 88(11):1123~1131 (5.004)

2010 SCI Predictive factors of pathologic complete response and clinical tumor progression after preoperative chemotherapy in patients with stage II and III breast cancer.: Investigational new drugs. Online:Published (3.072)

2010 SCI-E Oncological Safety and Quality of Life Associated with Mastectomy and Immediate Breast Reconstruction with a Latissimus Dorsi Myocutaneous Flap.: The breast journal. 16(4):356~361 (1.61)

2010 SCI Phase II Parallel Group Study Showing Comparable Efficacy Between Premenopausal Metastatic Breast Cancer Patients Treated With Letrozole Plus Goserelin and Postmenopausal Patients Treated With Letrozole Alone As First-Line Hormone Therapy: Journal of Clinical Oncology. 28(16):2705~2711 (17.793)

2010 SCI Hs.137007 is a novel epigenetic marker hypermethylated and up-regulated in breast cancer.: international journal of oncology. 36:1105~1111 (2.447)

2010 SCI Worse prognosis of metaplastic breast cancer patients than other patients with triple-negative breast cancer: Breast cancer research and treatment. 120(3):627~637 (4.696)

2010 SCI Jnk signaling pathway-mediated regulation of Stat3 activation is linked to the development of doxorubicin resistance in cancer cell lines: Biochemical Pharmacology. 79(3):373~380 (4.254)

2010 SCI Risk Factors for Malignancy in Benign Papillomas of the Breast on Core Needle Biopsy.: World Journal of Surgery. 34(2):261~265 (2.696)

2010 SCI Primary systemic therapy with intermittent weekly paclitaxel plus gemcitabine in patients with stage II and III breast cancer: a phase II trial: Investigational New Drugs. 28(1):83~90 (3.072)

2010 SCI Prognostic impact of [18F] FDG-PET in operable breast cancer treated with neoadjuvant chemotherpy: Annals of Surgical Oncology. 17(1):247~253 (4.13)

2009 SCI SP600125, an inhibitor of Jnk pathway, reduces viability of relatively resistant cancer cells to doxorubicin.: Biochemical and Biophysical Research Communications(상위20#이내 학술지 아님). 387(30:450~455 (2.648)

2009 SCI-E Fatty fish and fish omega-3 fatty acid intakes decrease the breast cancer risk: a case-control study: BioMedCentral Cancer. 9(1):216~216 (3.087)

2009 SCI-E Radiation pneumonitis after adjuvant radiotherapy for breast cancer: a volumetric analysis using CT simulator: Journal of Breast Cancer. 12(2):73~78 (0)

2008 SCI Analysis of chemotherapy-induced amenorrhea rates by three different anthracycline and taxane containing regimens for early breast cancer: Breast Cancer Research and Treatment. Online:Published (4.453)

2008 SCI Promoter hypomethylation of the N-acetyltransferase 1 gene in breast cancer: Oncology Reports. 19:663~8 (1.597)

2007 SCI A randomized phase-III trial of docetaxel/capecitabine versus doxorubicin/cyclophosphamide as primary chemotherapy for patients with stage II/III breast cancer.: Breast Cancer Research and Treatment. 109:481~489 (4.671)

2007 SCI Extent of rountine central lymphnode dissection with small palilloary thyroid carcinoma: World Journal Sug. 31:1954~1959 (1.765)

2007 SCI Extent of routine central lymph node dissection with small papillary thyroid carcinoma: World Journal of Surgery. 10:1954~1959 (1.765)

2007 SCI Sentinel node identification rate, but not accuracy, is significantly decreased after pre-operative chemotherapy in axillary node-positive breast cancer patients: Breast Cancer Research and Treatment. 102:283~288 (4.671)

2006 SCI Serum HER-2 concentration in patients with primary breast cancer: Journal of Clinical Pathology. 59:601~605 (2.17)

2006 SCI Epigenetic silencing of the sulftransferase1A1 gene by hypermethylation in breast tissue: Oncology Reports. 15:27~32 (1.572)

2005 SCI Tamoxifen-resistant breast cancers show less frequent methylation of the estrogen receptor beta but not the estrogen receptor alpha gene: JOURNAL OF MOLECULAR MEDICINE-JMM. 83:132~139 (4.82)

2004 SCI Decreased identification rate of sentinel lymph node after neoadjuvant chemotherapy: World Journal of Surgery. 28:1019~1024 (1.952)

2004 SCI Predictive value of [18F]FDG PET for pathological response of breast cancer to neo-adjuvant chemotherapy: ANNALS OF ONCOLOGY. 15(9):1352~1357 (4.319)

2004 SCI CpG methylation of the Erα and Erβ genes in breast cancer: INT J Mol MED. 14:289~293 (1.94)

2003 SCI Prevalence and Risk of Cancer of Focal Thyroid Incidentaloma Identified by F-18 Fluorodeoxyglucose-Position Emission Tomography for Metastasis Evaluation and Cancer-screening in Healthy Subjects: J Clin Endocrinol Metab. 88:4100~4104 (5.16)

2003 SCI High level expression of the bioactive human interleukin-10 in milk of transgenic mice: JOURNAL OF BIOTECHNOLOGY. 103:11~19 (2.323)

2001 SCI Interleukin-10 up-regulates tumour-necrosis-factor-a-related apoptosis-inducing ligand (TRAIL) gene expression in mammary epithelial cells at the involution stage: BIOCHEMICAL JOURNAL. 360:31~38 (4.278)

2001 SCI The timing and characterization of p53 mutations in progression from atypical ductal hyperplasia to invasive lesions in the breast cancer: J Mol Med. 79:648~655 (3.445)

2001 SCI Methylation in the p53 promoter is a supplementary route to breast carcinogenesis: Correlation between CpG methylation in the p53 promoter and the mutation of the p53 gene in the progression from ductal carcinoma in situ to invasive ductal carcinoma: LABORATORY INVESTIGATION. 81:571~599 (4.165)

2000 SCI Flow Cytometric Analysis of Primary Tumors and Their Corresponding Metastatic Nodes in Breast Cancer. Breast Cancer Research and Treatment.: Breast Cancer Research and Treatment. 63:81~87 (4.643)

저서

2005 유방학 / 한국유방암학회

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