연세대학교 의과대학 의학과 학사(1983) 연세대학교 대학원 의학석사(1986) 연세대학교 대학원 의학박사(1994)
경력
1990-1991 연세대학교 의과대학 소아신경학 연구강사 1991-1993 인제대학교 의과대학 상계백병원 소아과 전임강사 1993-1999 인제대학교 의과대학 상계백병원 소아과 조교수 1999-2003 인제대학교 의과대학 상계백병원 소아과 부교수 2001-2003 인제대학교 의과대학 상계백병원 소아과 과장 및 책임교수 2003-2006 연세대학교 의과대학 소아과학교실 부교수(신촌세브란스병원) 2006- 현재 연세대학교 의과대학 소아과학교실 교수(세브란스 어린이병원) 1994-1996 미국 펜실바니아대학 부속 필라델피아 소아병원 소아신경학 및 소아뇌전증 연구원 1995-1996 미국 뇌전증재단 선정 William G. Lennox 국제 뇌전증 연구원 2003 프랑스 파리 Rothschild Foundation Hospital 방문교수 2006- 현재 연세대학교 의과대학 장애아동연구소 소장 2009.2-2009.7 University of Pennsylvania, Children's Hospital of Philadelphia 2011.3-2017.2. 세브란스 어린이병원 소아신경과 과장
논문
2021 Clinical characteristics of KCNQ2 encephalopathy BRAIN & DEVELOPMENT
2020 Screening of Tuberous Sclerosis-Associated Neuropsychiatric Disorders in Korea Using the TAND Checklist Annals of Child Neurology
2020 Cannabidiol for Treating Lennox-Gastaut Syndrome and Dravet Syndrome in Korea JOURNAL OF KOREAN MEDICAL SCIENCE
2020 Epilepsy surgery for pediatric patients with mild malformation of cortical development SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
2020 Long-term outcomes of ketogenic diet in patients with tuberous sclerosis complex-derived epilepsy EPILEPSY RESEARCH
2020 Genetic diagnosis and clinical characteristics by etiological classification in early-onset epileptic encephalopathy with burst suppression pattern EPILEPSY RESEARCH
2020 Alteration in brain connectivity in patients with Dravet syndrome after vagus nerve stimulation (VNS): exploration of its effectiveness using graph theory analysis with electroencephalography JOURNAL OF NEURAL ENGINEERING
2020 Targeted gene panel sequencing in early infantile onset developmental and epileptic encephalopathy BRAIN & DEVELOPMENT
2020 Effective and safe diet therapies for Lennox-Gastaut syndrome with mitochondrial dysfunction Therapeutic Advances in Neurological Disorders
2020 Clinical Implementation of Targeted Gene Sequencing for Malformation of Cortical Development PEDIATRIC NEUROLOGY
2019 Precise detection of low-level somatic mutation in resected epilepsy brain tissue ACTA NEUROPATHOLOGICA
2019 Genetic and clinical features of SCN8A developmental and epileptic encephalopathy EPILEPSY RESEARCH
2019 Proband-Only Clinical Exome Sequencing for Neurodevelopmental Disabilities PEDIATRIC NEUROLOGY
2019 Optimized Treatment for Infantile Spasms: Vigabatrin versus Prednisolone versus Combination Therapy Journal of Clinical Medicine
2019 Short- and long-term seizure-free outcomes of dietary treatment in infants according to etiology Seizure - European Journal of Epilepsy
2019 Clobazam as an adjunctive treatment for infantile 넴는 Epilepsy & Behavior
2019 Epilepsy Surgery for Children With Low-Grade Epilepsy-Associated Tumors: Factors Associated With Seizure Recurrence and Cognitive Function PEDIATRIC NEUROLOGY
2018 Changes in functional brain network topology after successful and unsuccessful corpus callosotomy for Lennox-Gastaut Syndrome SCIENTIFIC REPORTS
2018 미토콘드리아 질환에서 웨스트 증후군 환자의 경련 발생 연령에 따른 임상 양상 비교 Journal of the Korean Child Neurology Society
2018 Rufinamide efficacy and safety in children aged 1-4?years with Lennox-Gastaut syndrome BRAIN & DEVELOPMENT
2018 Brain somatic mutations in SLC35A2 cause intractable epilepsy with aberrant N-glycosylation NEUROLOGY-GENETICS
2018 Diagnostic exome sequencing을 통한 KBG 증후군의 조기 진단 Journal of the Korean Child Neurology Society
2018 Long-term Outcome of Resective Epilepsy Surgery in Patients With Lennox-Gastaut Syndrome PEDIATRICS
2018 Interregional metabolic connectivity of 2-deoxy-2[18 F]fluoro-D-glucose positron emission tomography in vagus nerve stimulation for pediatric patients with epilepsy: A retrospective cross-sectional study EPILEPSIA
2018 Vigabatrin and high-dose prednisolone therapy for patients with West syndrome EPILEPSY RESEARCH
2018 The efficacy of ketogenic diet for specific genetic mutation in developmental and epileptic encephalopathy FRONTIERS IN NEUROLOGY
2018 Adverse Events During Perampanel Adjunctive Therapy in Intractable Epilepsy JOURNAL OF CLINICAL NEUROLOGY
2018 Differential effects on sodium current impairments by distinct SCN1A mutations in GABAergic neurons derived from Dravet syndrome patients BRAIN & DEVELOPMENT
2018 Targeted gene panel and genotype-phenotype correlation in children with developmental and epileptic encephalopathy EPILEPSY RESEARCH
2018 Efficient strategy for the molecular diagnosis of intractable early-onset epilepsy using targeted gene sequencing BMC MEDICAL GENOMICS
2018 Efficacy of Stiripentol in Dravet Syndrome with or without SCN1A Mutations JOURNAL OF CLINICAL NEUROLOGY
2017 Mowat-Wilson syndrome presenting with fever-associated seizures EPILEPTIC DISORDERS
2017 Altered brain functional connectivity induced by physical exercise may improve neuropsychological functions in patients with benign epilepsy EPILEPSY & BEHAVIOR
2017 Electroencephalography Network Effects of Corpus Callosotomy in Patients with Lennox-Gastaut Syndrome FRONTIERS IN NEUROLOGY
2017 Low glycemic index treatment in patients with drug-resistant epilepsy BRAIN & DEVELOPMENT
2017 국소 겉질 형성이상으로 인한 소아 뇌전증 환자에서 뇌전증 수술 후 항경련제 복용 중단 Journal of the Korean Child Neurology Society
2017 KCNT1 돌연변이가 확인된 영아 이동성 부분 발작뇌전증 환아에서의 Quinidine 치료를 시도한 영아 1예 Journal of the Korean Child Neurology Society
2017 드라베 증후군의 SCN1A 유전자 변이 양상 Journal of the Korean Child Neurology Society
2017 An Analysis of a Novel, Short-Term Therapeutic Psychoeducational Program for Children and Adolescents with Chronic Neurological Illness and Their Parents; Feasibility and Efficacy FRONTIERS IN NEUROSCIENCE
2017 Ketogenic Diet for the Management of Epilepsy Associated with Tuberous Sclerosis Complex in Children Journal of Epilepsy Research
2017 Modification of electrophysiological activity pattern after anterior thalamic deep brain stimulation for intractable epilepsy: report of 3 cases JOURNAL OF NEUROSURGERY
2017 Protein-Losing Enteropathy as a Complication of the Ketogenic Diet. YONSEI MEDICAL JOURNAL
2017 Spectral characteristics of intracranial electroencephalographic activity in patients with Lennox-Gastaut syndrome BRAIN & DEVELOPMENT
2017 Cause of Death in Children With Mitochondrial Diseases PEDIATRIC NEUROLOGY
2017 Somatic Mutations in TSC1 and TSC2 Cause Focal Cortical Dysplasia AMERICAN JOURNAL OF HUMAN GENETICS
2016 Estimating the Prevalence of Treated Epilepsy Using Administrative Health Data and Its Validity: ESSENCE Study JOURNAL OF CLINICAL NEUROLOGY
2016 Review of clinical studies of perampanel in adolescent patients BRAIN AND BEHAVIOR
2016 Ketogenic Diet for Children with Epilepsy: A Practical Meal Plan in a Hospital Clinical Nutrition Research
2016 Juvenile Myasthenia Gravis in Korea: Subgroup Analysis According to Sex and Onset Age JOURNAL OF CHILD NEUROLOGY
2016 Epilepsy Characteristics and Clinical Outcome in Patients With Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes (MELAS) PEDIATRIC NEPHROLOGY
2016 미토콘드리아 호흡연쇄 복합체 결함이 동반된 난치성 소아 뇌전증에서의 Zonisamide 부가 요법 Journal of the Korean Child Neurology Society
2016 Surgical versus medical treatment for children with epileptic encephalopathy in infancy and early childhood: Results of an international multicenter cohort study in Far-East Asia (the FACE study) BRAIN & DEVELOPMENT
2016 Surgical treatment of pediatric focal cortical dysplasia: Clinical spectrum and surgical outcome NEUROLOGY
2016 Predictive role of brain connectivity for resective surgery in Lennox-Gastaut syndrome CLINICAL NEUROPHYSIOLOGY
2016 Family factors contributing to emotional and behavioral problems in Korean adolescents with epilepsy EPILEPSY & BEHAVIOR
2016 The Impact of a 35-Week Long-Term Exercise Therapy on Psychosocial Health of Children With Benign Epilepsy. JOURNAL OF CHILD NEUROLOGY
2016 Efficacy of the classic ketogenic and the modified Atkins diets in refractory childhood epilepsy EPILEPSIA
2015 Parry-Romberg syndrome with ipsilateral hemipons involvement presenting as monoplegic ataxia Korean Journal of Pediatrics
2015 이차적 사경을 증상으로 한 척추 종양 Journal of the Korean Child Neurology Society
2015 The causal epileptic network identifies the primary epileptogenic zone in Lennox-Gastaut syndrome SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
2015 Chronic inflammatory demyelinating polyneuropathy in children: a report of four patients with variable relapsing courses Korean Journal of Pediatrics
2015 Applying the bacterial meningitis score in children with cerebrospinal fluid pleocytosis: a single center's experience Korean Journal of Pediatrics
2015 결절성 경화증 (Tuberous sclerosis) 환자에서 뇌실막밑 거대세포 별아교세포종의 (Subependymal giant cell astrocytoma) 치료 Journal of the Korean Child Neurology Society
2015 Neuropsychological effects of levetiracetam and carbamazepine in children with focal epilepsy NEUROLOGY
2015 Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy NATURE MEDICINE
2015 Screening for depression and anxiety disorder in children with headache Korean Journal of Pediatrics
2015 Long-term prognosis of patients with Lennox--Gastaut syndrome in recent decades EPILEPSY RESEARCH
2015 Perceived stigma in Korean adolescents with epilepsy: Effects of knowledge about epilepsy and maternal perception of stigma SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
2015 Neurocognitive function in children after anterior temporal lobectomy with amygdalohippocampectomy PEDIATRIC NEUROLOGY
2015 Localization of epileptogenic zones in Lennox-Gastaut syndrome (LGS) using graph theoretical analysis of ictal intracranial EEG: a preliminary investigation BRAIN & DEVELOPMENT
2014 Wernicke's encephalopathy in a child with high dose thiamine therapy Korean Journal of Pediatrics
2014 Myocardial atrophy in children with mitochondrial disease and Duchenne muscular dystrophy. Korean Journal of Pediatrics
2014 Psychological problems and clinical outcomes of children with psychogenic non-epileptic seizures YONSEI MEDICAL JOURNAL
2014 Congenital muscular dystrophy type 1A with residual merosin expression Korean Journal of Pediatrics
2014 A modified Atkin's diet for an infant with pyruvate dehydrogenase complex deficiency confirmed by PDHA1 gene mutation NEUROLOGY ASIA
2014 Adjunctive Levetiracetam Treatment in Pediatric Lennox-Gastaut Syndrome PEDIATRIC NEUROLOGY
2014 Epilepsy-related clinical factors and psychosocial functions in pediatric epilepsy EPILEPSY & BEHAVIOR
2014 The impact of an exercise therapy on psychosocial health of children with benign epilepsy: A pilot study EPILEPSY & BEHAVIOR
2014 Combined Use of Multiple Computational Intracranial EEG Analysis Techniques for the Localization of Epileptogenic Zones in Lennox-Gastaut Syndrome CLINICAL EEG AND NEUROSCIENCE
2014 Primary central nervous system anaplastic large cell lymphoma presenting initially with meningitis NEUROLOGY ASIA
2014 Outcomes of epilepsy surgery in childhood-onset epileptic encephalopathy BRAIN & DEVELOPMENT
2014 Changing name of epilepsy in Korea; cerebroelectric disorder(noi-jeon-jeung,뇌전증,): my epilepsy story. EPILEPSIA
2014 Polyunsaturated fatty acid-enriched diet therapy for a child with epilepsy BRAIN & DEVELOPMENT
2013 Relapsed herpes simplex virus encephalitis after epilepsy surgery Journal of Epilepsy Research
2013 Epilepsy Surgery in Pediatric Intractable Epilepsy with Destructive Encephalopathy Journal of Epilepsy Research
2013 The Significance of Insular Hypometabolism in Temporal Lobe Epilepsy in Children Journal of Epilepsy Research
2013 Quantitative Analysis of Simultaneous EEG Features during PET Studies for Childhood Partial Epilepsy YONSEI MEDICAL JOURNAL
2013 Schilder's disease in a young child with tumefactive demyelinating brain lesion NEUROLOGY ASIA
2013 The Usefulness of Diffusion Tensor Image-integrated Neuronavigation in Pediatric Epilepsy Surgery Korean Journal of Pediatric Neurosurgery (대한소아신경외과학회지)
2013 Clinical Presentations and the Bacterial Meningitis Score in Children with Cerebrospinal Fluid (CSF) Pleocytosis Journal of the Korean Child Neurology Society
2013 Interferon β-1b Treatment in a Korean Girl with Multiple Sclerosis Journal of the Korean Child Neurology Society
2013 Lower fat and better quality diet therapy for children with pharmacoresistant epilepsy Korean Journal of Pediatrics
2013 Localization of epileptogenic zones in Lennox?Gastaut syndrome using frequency domain source imaging of intracranial electroencephalography: a preliminary investigation PHYSIOLOGICAL MEASUREMENT
2013 Clinical analysis of catastrophic epilepsy in infancy and early childhood: Results of the Far-East Asia Catastrophic Epilepsy (FACE) study group BRAIN & DEVELOPMENT
2013 Seizure outcome of infantile spasms with focal cortical dysplasia BRAIN & DEVELOPMENT
2013 Mitochondrial disease and epilepsy BRAIN & DEVELOPMENT
2013 Catch-up growth after long-term implementation and weaning from ketogenic diet in pediatric epileptic patients CLINICAL NUTRITION
2013 Usefulness of Diffusion Tensor Tractography in Pediatric Epilepsy Surgery YONSEI MEDICAL JOURNAL
2012 Epilepsy in Korean patients with Angelman syndrome Korean Journal of Pediatrics
2012 Genetic and epileptic features in Rett syndrome YONSEI MEDICAL JOURNAL