김한상

  #대장암#간암#항암약물치료#신약치료

학력

연세대학교 의과대학 의학과 학사 (2008)
연세대학교 대학원 내과학 (세부분야: 종양학) 석사 (2012)
연세대학교 대학원 인체생물학 및 유전체학 이학박사 (2018)

경력

2008-2009 연세대학교 의과대학 세브란스병원 인턴 수료
2009-2013 연세대학교 의과대학 세브란스병원 내과 레지던트 수료
2013-2018 연세대학교 의과대학 의과학자 양성 과정 수료 (Physician-Scientist Program)
2016-2018 코넬 의대 Research Fellow
2018-2019 연세대학교 의과대학 내과학교실 종양내과 강사
2019-2020연세대학교 의과대학 내과학교실 종양내과 임상조교수
2020-현재 연세대학교 의과대학 내과학교실 종양내과 조교수

논문

* First Author
1. Kim S*, Kim HS*, Kim E, Lee MG, Shin E, Paik S, Kim S. Neopepsee: accurate genome-level prediction of neoantigens by harnessing sequence and amino acid immunogenicity information. Ann Oncol. 2018. 1;29(4):1030-1036. *co-first
2. Matei I*, Kim HS*, Lyden D. Unshielding exosomal RNA unleashes tumor growth and metastasis. Cell. 2017;170(2):223-225. *co-first

3. Kim HS*, Cheon JH*, Jung ES*, Park J, Aum S, Park SJ, Eun S, Lee J, Ruther U, Yeo GS, Ma M, Park KS, Naito T, Kakuta Y, Lee JH, Kim WH, Lee MG. A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD. Gut. 2017;66(11):1926-1935. *co-first

4. Kim HS*, Jung M*, Kang HN*, Kim H, Park CW, Kim SM, Shin SJ, Kim SH, Kim SG, Kim EK, Yun MR, Zheng Z, Chung KY, Greenbowe J, Ali SM, Kim TM, Cho BC. Oncogenic BRAF fusions in mucosal melanomas activate the MAPK pathway and are sensitive to MEK/PI3K inhibition or MEK/CDK4/6 inhibition. Oncogene. 2017;36(23):3334-3345. *co-first

5. Kim HS, Kwon HJ, Jung I, Yun MR, Ahn MJ, Kang BW, Sun JM, Kim SB, Yoon DH, Park KU, Lee SH, Koh YW, Kim SH, Choi EC, Koo DH, Sohn JH, Kim B, Kwon NJ, Yun HJ, Lee MG, Lee JH, Kim TM, Kim HR, Kim JH, Paik S, Cho BC. Phase II Clinical and Exploratory Biomarker Study of Dacomitinib in Patients with Recurrent and/or Metastatic Squamous Cell Carcinoma of Head and Neck. Clin Cancer Res. 2015;21(3):544-52. “Highlights” Selected Articles from CCR Vol. 21 Num. 3

6. Yoon JK*, Ahn J*, Kim HS*, Han SM, Jang H, Lee MG, Lee JH, Bang D. microDuMIP: target-enrichment technique for microarray-based duplex molecular inversion probes. Nucleic Acids Res. 2015;43(5). *co-first

7. Jung J*, Kim HS*, Lee MG, Yang EJ, Choi JY, Novel COCH p.V123E mutation, causative of DFNA9 sensorineural hearing loss and vestibular disorder, shows impaired cochlin post-translational cleavage and secretion. Hum Mutat. 2015;36(12):1168-75. *co-first

8. Ahn JW*, Kim HS*, Yoon JK*, Jang H, Han SM, Eun S, Shim HS, Cho BC, Lee JH, Bang D, et al. Identification of somatic mutations in EGFR/KRAS/ALK-negative lung adenocarcinoma in never-smokers. Genome Medicine. 2014;6(2):18 *co-first

9. Kim HS, Tetsuya Mitsudomi, Ross A. Soo, Cho BC. Personalized therapy on the horizon for squamous cell carcinoma of the lung, Lung Cancer. 2013;80 (3):249-55.
10. Kim HS, Lee S, et al. Randomized controlled trial of standardized education and telemonitoring for pain in outpatients with advanced Solid Tumor, Support Care Cancer. 2013;21(6):1751-9.

11. Kim HS, Shin SJ, Kim JH, Kim H, Choi HJ. Better Outcome of XELOX Chemotherapy in Patients with Advanced Intestinal-Type Adenocarcinoma of the Ampulla of Vater. Tohoku J Exp Med. 2013;231(1):21-8

12. Kim HS*, Kim SC*, Kim SJ, Park CH, Jeung HC, Kim YB, Ahn JB, Chung HC, Rha SY, Identification of a radiosensitivity signature using integrative metaanalysis of published microarray data for NCI-60 cancer cells. BMC Genomics. 2012;13(1):348. *co-first

13. Kim HS, Kim HR, Kim GM, Kim HS, Koh YW, Kim SH, Choi EC, Hong YK, Sung JH, Kim SM, Kim JH, Cho BC. The Efficacy and Toxicity of S-1 and Cisplatin as First-line Chemotherapy in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma. Cancer Chemother Pharmacol. 2012 Oct;70(4):539-46.
14. Kim HS, Kang SH, Park CH, Yang WI, Jeung HC, Chung HC, Roh JK, Ahn JB, Kim NK, Min BS, Rha SY. Genome-wide molecular characterization of mucinous colorectal adenocarcinoma using cDNA microarray analysis. Oncol Rep. 2011;25(3):717-27.

15. Kim HS, Pak HN, Park JS, Kim SS. Flecainide-Associated Bradycardia-Dependent Torsade de Pointes: Another Potential Mechanism of Proarrhythmia. Pacing Clin Electrophysiol. 2013;36(3):e84-6.

16. Kim HS, Chon HJ, Kim H, Shin SJ, Wacheck V, Gruver AM, Kim JS, Rha SY, Chung HC. MET in gastric cancer with liver metastasis: The relationship between MET amplification and Met overexpression in primary stomach tumors and liver metastasis. J Surg Oncol;117(8):1679-1686


* Contributing author
1. Rodrigues G, Hoshino A, Kenific CM, Matei IR, Steiner L, Freitas D, Kim HS, Oxley PR, Scandariato I, Casanova-Salas I, Dai J, Badwe CR, Gril B, Te?i? Mark M, Dill BD, Molina H, Zhang H, Benito-Martin A, Bojmar L, Ararso Y, Offer K, LaPlant Q, Buehring W, Wang H, Jiang X, Lu TM, Liu Y, Sabari JK, Shin SJ, Narula N, Ginter PS, Rajasekhar VK, Healey JH, Meylan E, Costa-Silva B, Wang SE, Rafii S, Altorki NK, Rudin CM, Jones DR, Steeg PS, Peinado H, Ghajar CM, Bromberg J, de Sousa M, Pisapia D, Lyden D. Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis. Nat Cell Biol. 2019;21(11):1403-1412

2. Zhang H, Freitas D*, Kim HS*, Fabijanic K, Li Z, Chen H, Mark MT, Molina H, Martin AB, Bojmar L, Fang J, Rampersaud S, Hoshino A, Matei I, Kenific C, Nakajima M, Mutvei AP, Sansone P, Buehring W, Wang H, Jimenez JP, Cohen-Gould L, Paknejad N, Brendel M, Manova-Todorova K, Magalhaes A, Ferreira JA, Osorio H, Silva AM, Massey A, Cubillos-Ruiz JR, Galletti G, Giannakakou P, Cuervo AM, Blenis J, Schwartz R, Brady MS, Peinado H, Bromberg J, Matsui H, Reis CA, Lyden D. Identification of novel nanoparticles and distinct exosome subsets via asymmetric-flow field-flow fractionation. Nat Cell Biol. 2018;20(3):332-343. *co-second

3. Becker A*, Thakur BK*, Weiss JM, Kim HS, Peinado H, Lyden D. Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis. Cancer Cell. 2016;30(6):836-848.

4. Kim W, Lee S, Kim HS, Song M, Cha YH, Kim YH, Shin J, Lee ES, Joo Y, Song JJ, Choi EJ, Choi JW, Lee J, Kang M, Yook JI, Lee MG, Kim YS, Paik S. Kim HH. Targeting mutant KRAS with CRISPR-Cas9 controls tumor growth. Genome Res. 2018. Epub.

5. Kim CG, Lee HW, Choi HJ, Lee JI, Lee HW, Kim SU, Park JY, Kim DY, Ahn SH, Han KH, Kim HS, Kim KH, Choi SJ, Kim Y, Lee KS, Kim GM, Kim MD, Won JY, Lee DY, Kim BK. Development and validation of a prognostic model for patients with hepatocellular carcinoma undergoing radiofrequency ablation. Cancer Med. 2019;8(11):5023-5032

6. Huang KK*, Jang KW*, Kim S, Kim HS, Kim SM, Kwon HJ, Kim HR, Yun HJ, Ahn MJ, Park KU, Ramnayanan K, McPherson J, Zhang S, Rhee J, Vettore A, Das K, Ishimoto T, Kim J, Koh YW, Kim SH, Choi EC, Teh BT, Rozen S, Kim T, Tan P. Exome sequencing reveals recurrent REV3L mutations in cisplatin-resistant squamous cell carcinoma of head and neck. Scientific Reports. 2016;21(6):19552.

7. Kim GM, Ahn JB, Rha SY, Kim HS, Kang B, Kim MW, Choi SY, Roh JK, Chung HC, Kim NK, Shin SJ. Changing Treatment Patterns in Elderly Patients with Resectable Colon Cancer. Asia-Pacific Journal of Clinical Oncology. 2013;9(3):265-72.

8. Lim S, Cho BC, Jung JY, Kim GM, Kim SH, Kim HR, Kim HS, Lim SM, Park JS, Lee JH, Kim D, Kim EY, Park MS, Kim YS, Kim SK, Chang J, Kim JH. Phase II study of camtobell inj. (belotecan) in combination with cisplatin in patients with previously untreated, extensive stage small cell lung cancer. Lung Cancer. 2013;80(3):313-8.

9. Leem AY, Kim HS, Yoo BW, Kang BD, Kim MH, Rha SY, and Kim HS. Ifosfamide-induced Fanconi syndrome with diabetes insipidus. Korean J Intern Med. 2014;29(2):246-249.

10. Rim HT*, Byun IH*, Kim HS, Lee SY, Yoon JS. Factors associated with diabetic retinopathy and nephropathy screening in Korea: The Third and Fourth Korea National Health and Nutrition Examination Survey (KNHANES III and IV). J Korean Med Sci. 2013;28(6):814-20.

11. Wittkowski KM, Dadurian C, Seybold MP, Kim HS, Hoshino A, Lyden D. Complex polymorphisms in endocytosis genes suggest alpha-cyclodextrin as a treatment for breast cancer. PLoS One. 2018;13(7):e0199012
Genome-wide molecular characterization of mucinous colorectal adenocarcinoma using cDNA microarray analysis
ONCOLOGY REPORTS 25/3 :717-727,2011

Identification of a radiosensitivity signature using integrative metaanalysis of published microarray data for NCI-60 cancer cells
BMC GENOMICS 13/348 :-,2012

The efficacy and toxicity of S-1 and cisplatin as first-line chemotherapy in recurrent or metastatic head and neck squamous cell carcinoma
CANCER CHEMOTHERAPY AND PHARMACOLOGY 70/4 :539-546,2012

Phase II study of camtobell inj. (belotecan) in combination with cisplatin in patients with previously untreated, extensive stage small cell lung cancer
LUNG CANCER 80/3 :313-318,2013

Factors Associated with Diabetic Retinopathy and Nephropathy Screening in Korea: The Third and Fourth Korea National Health and Nutrition Examination Survey (KNHANES III and IV)
JOURNAL OF KOREAN MEDICAL SCIENCE 28/6 :814-820,2013

Randomized controlled trial of standardized education and telemonitoring for pain in outpatients with advanced solid tumors
SUPPORTIVE CARE IN CANCER 21/6 :1751-1759,2013

Changing treatment patterns in elderly patients with resectable colon cancer
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY 9/3 :265-272,2013

Personalized therapy on the horizon for squamous cell carcinoma of the lung
LUNG CANCER 80/3 :249-255,2013

Flecainide-Associated Bradycardia-Dependent Torsade de Pointes: Another Potential Mechanism of Proarrhythmia
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY 36/3 :e84-e86,2013

Better Outcome of XELOX Chemotherapy in Patients with Advanced Intestinal-Type Adenocarcinoma of the Ampulla of Vater
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 231/ :21-28,2013

Ifosfamide-induced Fanconi syndrome with diabetes insipidus
KOREAN JOURNAL OF INTERNAL MEDICINE 29/2 :246-249,2014

Identification of somatic mutations in EGFR/KRAS/ALK-negative lung adenocarcinoma in never-smokers
GENOME MEDICINE 6/18 :1-10,2014

Phase II Clinical and Exploratory Biomarker Study of Dacomitinib in Patients with Recurrent and/or Metastatic Squamous Cell Carcinoma of Head and Neck
CLINICAL CANCER RESEARCH 21/3 :544-552,2015

microDuMIP: target-enrichment technique for microarray-based duplex molecular inversion probes
NUCLEIC ACIDS RESEARCH 43/5 :e28-e28,2015

Novel COCH p.V123E Mutation, Causative of DFNA9 Sensorineural Hearing Loss and Vestibular Disorder, Shows Impaired Cochlin Post-Translational Cleavage and Secretion
HUMAN MUTATION 36/12 :1168-1175,2015

Exome sequencing reveals recurrent REV3L mutations in cisplatin-resistant squamous cell carcinoma of head and neck
SCIENTIFIC REPORTS 6/ :19552-,2016

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis
CANCER CELL 30/6 :836-848,2016

Oncogenic BRAF fusions in mucosal melanomas activate the MAPK pathway and are sensitive to MEK/PI3K inhibition or MEK/CDK4/6 inhibition.
ONCOGENE 36/23 :3,334-3,345,2017

A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD.
GUT 66/11 :1,926-1,935,2017

Unshielding Exosomal RNA Unleashes Tumor Growth And Metastasis
CELL 170/2 :223-225,2017

Neopepsee: accurate genome-level prediction of neoantigens by harnessing sequence and amino acid immunogenicity information
ANNALS OF ONCOLOGY 29/4 :1,030-1,036,2018

Targeting mutant KRAS with CRISPR-Cas9 controls tumor growth
GENOME RESEARCH 28/3 :374-382,2018

MET in gastric cancer with liver metastasis: The relationship between MET amplification and Met overexpression in primary stomach tumors and liver metastasis
JOURNAL OF SURGICAL ONCOLOGY 117/8 :1,679-1,686,2018

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation
NATURE CELL BIOLOGY 20/3 :332-343,2018

Complex polymorphisms in endocytosis genes suggest alpha-cyclodextrin as a treatment for breast cancer
PLOS ONE 13/7 :e0199012-e0199043,2018

저서

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보도자료

연세의료원, Nature 발표 암 연구 의료기관 국내 1위...세계 75위
https://cp.news.search.daum.net/p/93531543

연세의료원, 네이쳐가 인정한 암 연구 의료기관 국내 1위. 세계75위
http://v.media.daum.net/v/20200514090918601?f=o

연세의료원, 네이처 '암 연구 100대 기관' 중 국내 1위
http://v.media.daum.net/v/20200513192253747?f=o

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