정지향

교수
    

  #퇴행성뇌질환(치매) #기억력 및 인지기능장애 #언어장애 #행동장애 #치매예방 #웰에이징 #AI 진단 #보호자 케어 #연령별 치매 예방 #3대 뇌질환#헬스조선명의

학력

이화여자대학교 의과대학 박사(신경병리학)
이화여자대학교 의과대학 석사
이화여자대학교 의과대학 졸업

경력

1994-1995 | 이대동대문병원 인턴
1996-2000 | 이대동대문병원 신경과 전공의
2000-2001 | 삼성서울병원 신경과 전임의(치매/인지장애 및 행동신경학)
2001-2002 | 한국에자이제약회사 의학부 이사
2002-2003 | 이대목동병원 임상강사(치매클리닉/뇌졸중)
2003 | UCLA, Alzheimer’s disease and Research Center, Pathology lab, visiting Instructor
2003-2004 | University of California, San Franscisco, Alzheimer’s disease and Research Center, Visiting Instructor
2004-2005 | 이대목동병원 신경과 임상강사(치매 및 노인신경학)
2005-2008 | 이대목동병원 신경과 조교수
2008-2014 | 이대목동병원 신경과 부교수
2010-2011 | 서울시 서남병원 신경과 과장 및 공공의료단 단장역임
2011-2012 | 이화의료원 운영 서울시 서남병원 신경과 과장 및 공공의료단 단장
2012-2013 | University College of London, National Hospital for Neurology and Neurosurgery, Dementia Research Center, Honorary Visiting Professor
2014-2019 | 이대목동병원 임상의학연구부장/임상시험센터장
2014-2020 | 이대목동병원 임상시험센터장
2014-현재 | 이대목동병원 신경과 과장
2014-현재 | 이대목동병원 신경과 교수
2019-현재 | 이대목동병원 뇌과학연구소장
2019-현재 | 이화여자대학 의과대학 신경과학교실 주임교수
2020-현재 | 이화의료원 헬스케어시스템부장

논문

South Korean Study to Prevent Cognitive Impairment and Protect Brain Health Through Lifestyle Intervention in At-Risk Elderly People: Protocol of a Multicenter, Randomized Controlled Feasibility Trial. 2020-04.

Telomere shortening reflecting physical aging is associated with cognitive decline and dementia conversion in mild cognitive impairment due to Alzheimer's disease. 2020-03.

암 환자에서 연수막 전이 진단표지자로서의 뇌척수액 CYFRA 21-1. 2019-05.

APOE Promoter Polymorphism-219T/G is an Effect Modifier of the Influence of APOE epsilon 4 on Alzheimer's Disease Risk in a Multiracial Sample. 2019-08.

Observational Study of Clinical and Functional Progression Based on Initial Brain MRI Characteristics in Patients with Alzheimer's Disease. 2018-01.

Clinical and Biomarker Characteristics According to Clinical Spectrum of Alzheimer's Disease (AD) in the Validation Cohort of Korean Brain Aging Study for the Early Diagnosis and Prediction of AD. 2019-03.

A Multicenter, Randomized Clinical Trial to Assess the Efficacy of a Therapeutic Intervention Program for Caregivers of People with Dementia. 2019-04.

A Comparative Evaluation of the KDSQ-C, AD8, and SMCQ as a Cognitive Screening Test to Be Used in National Medical Check-ups in Korea. 2019-04.

Blood amyloid- oligomerization associated with neurodegeneration of Alzheimer's disease. 2019-05.

Association of Nutritional Status with Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease. 2019-07.

Clustering and Switching Patterns in Semantic Fluency and Their Relationship to Working Memory in Mild Cognitive Impairment. 2019-06.

Effect of 12-week home-based cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment. 2019-06.

Self- and informant-reported cognitive functioning and awareness in subjective cognitive decline, mild cognitive impairment, and very mild Alzheimer disease. 2020-01.

Cerebrospinal Fluid Biomarkers for the Diagnosis of Alzheimer Disease in South Korea. 2017-01.

Anosognosia and Its Relation to Psychiatric Symptoms in Early-Onset Alzheimer Disease. 2017-05.

Prediction Model of Conversion to Dementia Risk in Subjects with Amnestic Mild Cognitive Impairment: A Longitudinal, Multi-Center Clinic-Based Study. 2017-01.

PSEN1 p. Thr116Ile Variant in Two Korean Families with Young Onset Alzheimer's Disease. 2018-09.

Predictors of Institutionalization in Patients with Alzheimer's Disease in South Korea. 2018-04.

Age-Specific Cutoff Scores on a T1-Weighted Axial Medial Temporal-Lobe Atrophy Visual Rating Scale in Alzheimer's Disease Using Clinical Research Center for Dementia of South Korea Data. 2018-07.

Effect of Physical Activity on the Progression of Alzheimer's Disease: The Clinical Research Center for Dementia of South Korea Study. 2018-01.

Effectiveness of Anti-Dementia Drugs in Extremely Severe Alzheimer's Disease: A 12-Week, Multicenter, Randomized, Single-Blind Study. 2018-01.

Analysis of frontotemporal dementia, amyotrophic lateral sclerosis, and other dementia-related genes in 107 Korean patients with frontotemporal dementia. 2018-12.

A genetic screen of the mutations in the Korean patients with early-onset Alzheimer's disease. 2016-11.

Prognosis of Patients with Behavioral Variant Frontotemporal Dementia Who have Focal Versus Diffuse Frontal Atrophy. 2017-07.

Clinical characteristics of parkinsonism in frontotemporal dementia according to subtypes. 2017-01.

Effect of Individual and District-level Socioeconomic Disparities on Cognitive Decline in Community-dwelling Elderly in Seoul. 2017-09.

Diagnostic and prognostic values of cerebrospinal fluid CYFRA 21-1 in patients with leptomeningeal carcinomatosis. 2017-08.

알츠하이머병과 피질하혈관치매의 언어유창성검사수행능력 차이: 노인성치매임상연구센터 연구. 2016-02.

The Effect of Processing Load on Semantic and Phonological Working Memory in Mild Cognitive Impairment. 2016-06.

Encephalopathy in an Elderly Patient Following Oral Ingestion of Topical Methyl Salicylate. 2016-06.

Effects of Ganglioside on Working Memory and the Default Mode Network in Individuals with Subjective Cognitive Impairment: A Randomized Controlled Trial. 2016-04.

Clinical Predictors for Mild Cognitive Impairment Progression in a Korean Cohort. 2016-09.

Recent Updates of Therapeutic Intervention Programs for Caregivers of Patient with Dementia: Proposal of Hospital-Based Individual Therapy. 2016-06.

Amyloid Beta-Mediated Hypomethylation of Heme Oxygenase 1 Correlates with Cognitive Impairment in Alzheimer's Disease. 2016-04.

Higher Physical Activity Is Associated with Increased Attentional Network Connectivity in the Healthy Elderly. 2016-08.

Effects of working memory treatment using verb-carrier phrases on language processing in persons with mild cognitive impairment. 2016-09.

Factors related to prevalence, persistence, and incidence of depressive symptoms in mild cognitive impairment: vascular depression construct. 2016-07.

Group- and Home-Based Cognitive Intervention for Patients with Mild Cognitive Impairment: A Randomized Controlled Trial. 2016-01.

The effects of semantic feature analysis treatment on naming performance in Korean individuals with early dementia of the Alzheimer's type: Using a familiarity of nouns scale. 2015-03.

Elevation of the Plasma A beta(40)/A beta(42) Ratio as a Diagnostic Marker of Sporadic Early-Onset Alzheimer's Disease. 2015-01.

Reduced Gray Matter Density in the Posterior Cerebellum of Patients with Panic Disorder : A Voxel-Based Morphometry Study. 2015-02.

Normative Study of the Literacy Independent Cognitive Assessment in Illiterate and Literate Elderly Koreans. 2015-07.

Hippocampal volume and shape in pure subcortical vascular dementia. 2015-01.

The Effects of Galantamine Treatment on Attention and Its Relationship with Cognition and Activities of Daily Living in Patients with Mild to Moderate Alzheimer's Disease?. 2015-01.

Body Mass Index and Mortality Rate in Korean Patients with Alzheimer's Disease. 2015-01.

Structural Brain Changes after Traditional and Robot-Assisted Multi-Domain Cognitive Training in Community-Dwelling Healthy Elderly. 2015-04.

Clinical evolution, neuroimaging, and volumetric analysis of a patient with a CSF1R mutation who presented with progressive nonfluent aphasia. 2015-07.

Gender differences in risk factors for transition from mild cognitive impairment to Alzheimer's disease: A CREDOS study. 2015-10.

Predictors of Clinical Progression of Subjective Memory Impairment in Elderly Subjects: Data from the Clinical Research Centers for Dementia of South Korea (CREDOS). 2015-01.

Literacy Independent Cognitive Assessment: Assessing Mild Cognitive Impairment in Older Adults with Low Literacy Skills. 2015-07.

The Heterogeneity and Natural History of Mild Cognitive Impairment of Visual Memory Predominant Type. 2015-01.

저서

저서 내용이 없습니다.

보도자료

[쿠키뉴스] [치매 일상예찬-⑤] 치매환자 돌보는 당신에게 감사합니다
http://www.kukinews.com/newsView/kuk201707240147

[한국경제] [건강한 인생] "남편이 치매 걸리면 아내도 비슷한 고통 겪죠"
https://www.hankyung.com/society/article/2016102650381

[동아일보] “치매 돌보는 사람도 치료해야 효과”… ‘보호자 케어’ 개발 선구자
https://www.donga.com/news/article/all/20201107/103841522/1

포스팅

포스팅 내용이 없습니다.

영상자료

[MBC] '면허증 반납'이 답?…"나이 들수록 차 필요한데"
https://imnews.imbc.com/replay/2019/nwdesk/article/5289181_28802.html

[KBS 생로병사의 비밀] 특집 치매와의 전쟁 - 1편 치매쇼크
https://vod.kbs.co.kr/index.html?source=episode&sname=vod&stype=vod&program_code=T2002-0429&program_id=PS-2019103120-01-000§ion_code=05&broadcast_complete_yn=N&local_station_code=00§ion_sub_code=03

[KBS 무엇이든 물어보세요] 치매는 불치병이다? 치매에 대한 오해와 진실
https://vod.kbs.co.kr/index.html?source=episode&sname=vod&stype=vod&program_code=T2000-0038&program_id=PS-2019207869-01-000§ion_code=05&broadcast_complete_yn=N&local_station_code=00§ion_sub_code=03

발표자료

(특허) 알츠하이머병 치매의 발병 위험성 예측을 위한 후성 유전학적 진단 키트 개발

(특허) TNFRSF19 유전자의 DNA 메틸레이션 변화를 이용한 알츠하이머병 치매 조기진단 마커

(특허) 알츠하이머병 치매 관련 유전자 바이오마커 및 이의 이용

(특허) 알츠하이머병 치매 특이적 DNA 메틸레이션 마커 검출용 조성물 및 검출방법

(특허) 알츠하이머병 경도인지장애의 진단 또는 알츠하이머병 치매로의 진행 위험성 예측 방법

(특허) 알츠하이머병 치매 특이적 유전자 NHLRC4 및 이를 이용한 알츠하이머병 치매 예측

(특허) 유전자 CpG 메틸화 변화를 이용한 알츠하이머병 치매 진단용 조성물 및 이의 이용

(특허) 유전자의 DNA 메틸레이션 변화를 이용한 알츠하이머병 경도인지장애의 진단 마커

(특허) 알츠하이머병 치매 조기 진단을 위한 후성 유전학적 진단 키트 개발

(특허) 알츠하이머병 치매 치료를 위한 분자 진단 테스트

(특허) 피부 세포에서 IDE 유전자 프로모터의 CpG 메틸화 변화를 이용한 알츠하이머 질환 진단용 조성물 및 이의 이용

(특허) 상호작용 가능한 블록 도구

(특허) 체감형 인터랙티브 콘텐츠를 제공하기 위한 도구 및 그 방법

(특허) 피부 세포에서 IDE 유전자 프로모터의 CpG 메틸화 변화를 이용한 알츠하이머 질환 진단용 조성물 및 이의 이용

(특허) 퇴행성 질환의 조기 발견을 위한 언어능력진단 시스템, 방법 및 이를 제공하기 위한 컴퓨터 프로그램이 기록된 컴퓨터로 판독가능한 기록 매체

(특허) 경도 인지 장애 및 알츠하이머성 치매 진단을 위한 문장 이해력 및 표현력 검사 장치 및 방법