박경수
#임상약리#임상시험#적정약물요법#약동약력학 모델링
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학력
서울대학교 전자공학 학사(1987)
Univ. of Southern California 의공학 박사(1994)
연세대학교 의학과 학사(2004)
Univ. of Southern California 의공학 박사(1994)
연세대학교 의학과 학사(2004)
경력
1995-1997 미국 USCF대학교 의과대학 Postdoctoral fellow
1997-1998 미국 Northwestern 대학교 Research Assistant Professor
1998-2000 미국 Northwestern 대학교 Consulting faculty
2004-2005 연세의대 약리학교실 전임강사
2005-2009 연세의대 약리학교실 조교수
2009-2014 연세의대 약리학교실 부교수
2014-현재 연세의대 약리학교실 교수
1997-1998 미국 Northwestern 대학교 Research Assistant Professor
1998-2000 미국 Northwestern 대학교 Consulting faculty
2004-2005 연세의대 약리학교실 전임강사
2005-2009 연세의대 약리학교실 조교수
2009-2014 연세의대 약리학교실 부교수
2014-현재 연세의대 약리학교실 교수
논문
Race and sex influence clearance of nifedipine: Results of a population study
CLINICAL PHARMACOLOGY & THERAPEUTICS 68/2 :130-142,2000
국내인에서의 항생제 약동학 모델링 : 아미카신의 적용예
감염과화학요법 37/1 :S34-39,2005
Bispectral index does not correlate with observer assessment of alertness and sedation scores during 0.5% bupivacaine epidural anesthesia with nitrous oxide sedation
ANESTHESIA AND ANALGESIA 103/2 :385-389,2006
Influence of the CYP3A5 and MDR1 genetic polymorphisms on the pharmacokinetics of tacrolimus in healthy Korean subjects
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 64/2 :185-191,2007
A randomized, open-label, two-period, crossover bioavailability study of two oral formulations of tacrolimus in healthy Korean adults
CLINICAL THERAPEUTICS 29/1 :154-162,2007
Influence of OATP1B1 genotype on the pharmacokinetics of rosuvastatin in Koreans
Clinical Pharmacology & Therapeutics 83/ :251-257,2008
Phase II Study of Transarterial Holmium-166-Chitosan Complex Treatment in Patients with a Single, Large Hepatocellular Carcinoma
Oncology 76/1 :1-9,2009
Pharmacokinetic properties and tissue storage of FITC conjugated SA-MnMEIO nanoparticles in mice
Current Applied Physics 9/0 :e304-e307,2009
Nerve growth factor and expression of its receptors in patients with diabetic neuropathy
Diabetic Medicine 26/12 :1228-1234,2009
Pharmacokinetic Comparison of Controlled-Release and Immediate-Release Oral Formulations of Simvastatin in Healthy Korean Subjects: A Randomized, Open-Label, Parallel-Group, Single- and Multiple-Dose Study
Clinical Therapeutics 32/ :206-216,2010
A phase I pharmacokinetic and pharmacodynamic study of CKD-732, an antiangiogenic agent, in patients with refractory solid cancer
Investigational New Drugs 28/5 :650-658,2010
Modeling the Effect of Sevoflurane on Corrected QT Prolongation A Pharmacodynamic Analysis
Anesthesiology 113/ :806-811,2010
Prognostic Factors in Small Cell Lung Cancer: A New Prognostic Index in Korean Patients
Oncology 79/3-4 :293-300,2010
PEG-인터페론 알파-2a 제제 DA-3021의 안전성 및 약동력학적 특성 연구
Journal Of Korean Society For Clinical Pharmacology And Therapeutics 18/2 :117-126,2010
Effect of CYP2B6 Genotype on the Pharmacokinetics of Sibutramine and Active Metabolites in Healthy Subjects
JOURNAL OF CLINICAL PHARMACOLOGY 51/1 :53-59,2011
Rifampin Enhances the Glucose-Lowering Effect of Metformin and Increases OCT1 mRNA Levels in Healthy Participants
CLINICAL PHARMACOLOGY & THERAPEUTICS 89/3 :416-421,2011
The effect of beta1-adrenergic receptor gene polymorphism on prolongation of corrected QT interval during endotracheal intubation under sevoflurane anesthesia
Korean Journal of Anesthesiology 61/2 :117-121,2011
Population pharmacokinetics of amikacin in a Korean clinical population
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 49/6 :371-381,2011
The T2-Shortening Effect of Gadolinium and the Optimal Conditions for Maximizing the CNR for Evaluating the Biliary System: a Phantom Study
KOREAN JOURNAL OF RADIOLOGY 12/3 :358-364,2011
Pharmacokinetic Comparison of Sustained- and Immediate-Release Oral Formulations of Cilostazol in Healthy Korean Subjects: A Randomized, Open-Label, 3-Part, Sequential, 2-Period, Crossover, Single-Dose, Food-Effect, and Multiple-Dose Study
CLINICAL THERAPEUTICS 33/12 :2038-2053,2011
A Phase Ib pharmacokinetic study of the anti-angiogenic agent CKD-732 used in combination with capecitabine and oxaliplatin (XELOX) in metastatic colorectal cancer patients who progressed on irinotecan-based chemotherapy
INVESTIGATIONAL NEW DRUGS 30/ :672-680,2012
The views of patients and healthy volunteers on participation in clinical trials: An exploratory survey study
CONTEMPORARY CLINICAL TRIALS 33/ :611-619,2012
Modeling of the LDL cholesterol-lowering effect of atorvastatin in Korean dyslipidemic patients and non-patient volunteers.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 50/9 :647-656,2012
The UGT1A3*2 polymorphism affects atorvastatin lactonization and lipid-lowering effect in healthy volunteers
PHARMACOGENETICS AND GENOMICS 22/8 :598-605,2012
Pharmacokinetic Comparison of an Orally Disintegrating Film Formulation With a Film-Coated Tablet Formulation of Sildenafil in Healthy Korean Subjects: A Randomized, Open-Label, Single-Dose, 2-Period Crossover Study
CLINICAL THERAPEUTICS 35/3 :205-214,2013
Pharmacokinetics of Rosuvastatin/Olmesartan Fixed-Dose Combination: A Single-Dose, Randomized, Open-Label, 2-Period Crossover Study in Healthy Korean Subjects
CLINICAL THERAPEUTICS 35/7 :915-922,2013
Pharmacokinetic Comparison of 2 Fixed-Dose Combination Tablets of Amlodipine and Valsartan in Healthy Male Korean Volunteers: A Randomized, Open-Label, 2-Period, Single-Dose, Crossover Study
CLINICAL THERAPEUTICS 35/7 :934-940,2013
Development of a Pharmacokinetic Interaction Model for Co-administration of Simvastatin and Amlodipine
DRUG METABOLISM AND PHARMACOKINETICS 29/2 :120-128,2014
Pharmacokinetic Interaction between Rosuvastatin and Telmisartan in Healthy Korean Male Volunteers: A Randomized, Open-label, Two-period, Crossover, Multiple-dose Study
CLINICAL THERAPEUTICS 36/8 :1147-1158,2014
Pharmacokinetic Interaction between Rosuvastatin and Olmesartan: A Randomized, Open-label, 3-period, Multiple-dose Crossover Study in Healthy Korean Male Subjects
CLINICAL THERAPEUTICS 36/8 :1159-1170,2014
Pharmacokinetic Interaction between Rosuvastatin and Metformin in Healthy Korean Male Volunteers: A Randomized, Open-label, 3-period, Crossover, Multiple-dose Study
CLINICAL THERAPEUTICS 36/8 :1171-1181,2014
Population pharmacokinetic analysis of diurnal and seasonal variations of plasma concentrations of cilostazol in healthy volunteers
THERAPEUTIC DRUG MONITORING 36/6 :771-780,2014
Pharmacokinetics of a telmisartan/rosuvastatin fixed-dose combination: a single-dose, randomized, open-label, 2-period crossover study in healthy Korean subjects
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 53/10 :883-889,2015
Modelling of the Effect of End-Tidal Carbon Dioxide on Cerebral Oxygen Saturation in Beach Chair Position under General Anaesthesia
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 119/1 :85-92,2016
Pore dilatation increases the bicarbonate permeability of CFTR, ANO1 and glycine receptor anion channels
JOURNAL OF PHYSIOLOGY-LONDON 594/11 :2929-2955,2016
Pharmacokinetics of a nanocrystal-containing megestrol acetate formulation: A Single-Dose, Randomized, Open-Label, 2-Part, 2-Period Crossover Study in Healthy Korean Subjects
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 54/9 :698-704,2016
Quantitative Model for the Blood Pressure Lowering Interaction of Valsartan and Amlodipine
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 82/6 :1,557-1,567,2016
Quantitative assessment of food effect on the pharmacokinetics of nano-crystallized megestrol acetate
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 120/3 :270-277,2017
Experience and pharmacokinetics of Levetiracetam in Korean neonates with neonatal seizures
Korean Journal of Pediatrics 60/2 :50-54,2017
A Review of Modeling Approaches to Predict Drug Response in Clinical Oncology
YONSEI MEDICAL JOURNAL 58/1 :1-8,2017
Mechanistic Model for Blood Pressure and Heart Rate Changes Produced by Telmisartan in Human Beings
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 122/1 :139-148,2018
An item response theory based integrated model of headache, nausea, photophobia, and phonophobia in migraine patients
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS 45/5 :721-731,2018
Model-based assessment of the benefits and risks of recombinant tissue plasminogen activator treatment in acute ischaemic stroke
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 84/11 :2,586-2,599,2018
A Prediction Model of Tumor Progression and Survival in HER2-Positive Metastatic Gastric Cancer Patients Treated with Trastuzumab and Chemotherapy
AAPS JOURNAL 20/4 :72-87,2018
Population PK-PD Model of Pegylated Interferon Alfa-2a in Healthy Korean Men
JOURNAL OF PHARMACEUTICAL SCIENCES 107/12 :3,171-3,178,2018
Population pharmacokinetic model of levetiracetam in Korean neonates with seizures
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 56/5 :217-223,2018
Optimal Dosing Regimen of Phenytoin for Korean Epilepsy Patients: From Premature Babies to the Elderly
JOURNAL OF PHARMACEUTICAL SCIENCES 108/8 :2,765-2,773,2019
Predicting Disease Progression in Patients with Bicuspid Aortic Stenosis Using Mathematical Modeling
Journal of Clinical Medicine 8/9 :E1302-,2019
CLINICAL PHARMACOLOGY & THERAPEUTICS 68/2 :130-142,2000
국내인에서의 항생제 약동학 모델링 : 아미카신의 적용예
감염과화학요법 37/1 :S34-39,2005
Bispectral index does not correlate with observer assessment of alertness and sedation scores during 0.5% bupivacaine epidural anesthesia with nitrous oxide sedation
ANESTHESIA AND ANALGESIA 103/2 :385-389,2006
Influence of the CYP3A5 and MDR1 genetic polymorphisms on the pharmacokinetics of tacrolimus in healthy Korean subjects
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 64/2 :185-191,2007
A randomized, open-label, two-period, crossover bioavailability study of two oral formulations of tacrolimus in healthy Korean adults
CLINICAL THERAPEUTICS 29/1 :154-162,2007
Influence of OATP1B1 genotype on the pharmacokinetics of rosuvastatin in Koreans
Clinical Pharmacology & Therapeutics 83/ :251-257,2008
Phase II Study of Transarterial Holmium-166-Chitosan Complex Treatment in Patients with a Single, Large Hepatocellular Carcinoma
Oncology 76/1 :1-9,2009
Pharmacokinetic properties and tissue storage of FITC conjugated SA-MnMEIO nanoparticles in mice
Current Applied Physics 9/0 :e304-e307,2009
Nerve growth factor and expression of its receptors in patients with diabetic neuropathy
Diabetic Medicine 26/12 :1228-1234,2009
Pharmacokinetic Comparison of Controlled-Release and Immediate-Release Oral Formulations of Simvastatin in Healthy Korean Subjects: A Randomized, Open-Label, Parallel-Group, Single- and Multiple-Dose Study
Clinical Therapeutics 32/ :206-216,2010
A phase I pharmacokinetic and pharmacodynamic study of CKD-732, an antiangiogenic agent, in patients with refractory solid cancer
Investigational New Drugs 28/5 :650-658,2010
Modeling the Effect of Sevoflurane on Corrected QT Prolongation A Pharmacodynamic Analysis
Anesthesiology 113/ :806-811,2010
Prognostic Factors in Small Cell Lung Cancer: A New Prognostic Index in Korean Patients
Oncology 79/3-4 :293-300,2010
PEG-인터페론 알파-2a 제제 DA-3021의 안전성 및 약동력학적 특성 연구
Journal Of Korean Society For Clinical Pharmacology And Therapeutics 18/2 :117-126,2010
Effect of CYP2B6 Genotype on the Pharmacokinetics of Sibutramine and Active Metabolites in Healthy Subjects
JOURNAL OF CLINICAL PHARMACOLOGY 51/1 :53-59,2011
Rifampin Enhances the Glucose-Lowering Effect of Metformin and Increases OCT1 mRNA Levels in Healthy Participants
CLINICAL PHARMACOLOGY & THERAPEUTICS 89/3 :416-421,2011
The effect of beta1-adrenergic receptor gene polymorphism on prolongation of corrected QT interval during endotracheal intubation under sevoflurane anesthesia
Korean Journal of Anesthesiology 61/2 :117-121,2011
Population pharmacokinetics of amikacin in a Korean clinical population
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 49/6 :371-381,2011
The T2-Shortening Effect of Gadolinium and the Optimal Conditions for Maximizing the CNR for Evaluating the Biliary System: a Phantom Study
KOREAN JOURNAL OF RADIOLOGY 12/3 :358-364,2011
Pharmacokinetic Comparison of Sustained- and Immediate-Release Oral Formulations of Cilostazol in Healthy Korean Subjects: A Randomized, Open-Label, 3-Part, Sequential, 2-Period, Crossover, Single-Dose, Food-Effect, and Multiple-Dose Study
CLINICAL THERAPEUTICS 33/12 :2038-2053,2011
A Phase Ib pharmacokinetic study of the anti-angiogenic agent CKD-732 used in combination with capecitabine and oxaliplatin (XELOX) in metastatic colorectal cancer patients who progressed on irinotecan-based chemotherapy
INVESTIGATIONAL NEW DRUGS 30/ :672-680,2012
The views of patients and healthy volunteers on participation in clinical trials: An exploratory survey study
CONTEMPORARY CLINICAL TRIALS 33/ :611-619,2012
Modeling of the LDL cholesterol-lowering effect of atorvastatin in Korean dyslipidemic patients and non-patient volunteers.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 50/9 :647-656,2012
The UGT1A3*2 polymorphism affects atorvastatin lactonization and lipid-lowering effect in healthy volunteers
PHARMACOGENETICS AND GENOMICS 22/8 :598-605,2012
Pharmacokinetic Comparison of an Orally Disintegrating Film Formulation With a Film-Coated Tablet Formulation of Sildenafil in Healthy Korean Subjects: A Randomized, Open-Label, Single-Dose, 2-Period Crossover Study
CLINICAL THERAPEUTICS 35/3 :205-214,2013
Pharmacokinetics of Rosuvastatin/Olmesartan Fixed-Dose Combination: A Single-Dose, Randomized, Open-Label, 2-Period Crossover Study in Healthy Korean Subjects
CLINICAL THERAPEUTICS 35/7 :915-922,2013
Pharmacokinetic Comparison of 2 Fixed-Dose Combination Tablets of Amlodipine and Valsartan in Healthy Male Korean Volunteers: A Randomized, Open-Label, 2-Period, Single-Dose, Crossover Study
CLINICAL THERAPEUTICS 35/7 :934-940,2013
Development of a Pharmacokinetic Interaction Model for Co-administration of Simvastatin and Amlodipine
DRUG METABOLISM AND PHARMACOKINETICS 29/2 :120-128,2014
Pharmacokinetic Interaction between Rosuvastatin and Telmisartan in Healthy Korean Male Volunteers: A Randomized, Open-label, Two-period, Crossover, Multiple-dose Study
CLINICAL THERAPEUTICS 36/8 :1147-1158,2014
Pharmacokinetic Interaction between Rosuvastatin and Olmesartan: A Randomized, Open-label, 3-period, Multiple-dose Crossover Study in Healthy Korean Male Subjects
CLINICAL THERAPEUTICS 36/8 :1159-1170,2014
Pharmacokinetic Interaction between Rosuvastatin and Metformin in Healthy Korean Male Volunteers: A Randomized, Open-label, 3-period, Crossover, Multiple-dose Study
CLINICAL THERAPEUTICS 36/8 :1171-1181,2014
Population pharmacokinetic analysis of diurnal and seasonal variations of plasma concentrations of cilostazol in healthy volunteers
THERAPEUTIC DRUG MONITORING 36/6 :771-780,2014
Pharmacokinetics of a telmisartan/rosuvastatin fixed-dose combination: a single-dose, randomized, open-label, 2-period crossover study in healthy Korean subjects
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 53/10 :883-889,2015
Modelling of the Effect of End-Tidal Carbon Dioxide on Cerebral Oxygen Saturation in Beach Chair Position under General Anaesthesia
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 119/1 :85-92,2016
Pore dilatation increases the bicarbonate permeability of CFTR, ANO1 and glycine receptor anion channels
JOURNAL OF PHYSIOLOGY-LONDON 594/11 :2929-2955,2016
Pharmacokinetics of a nanocrystal-containing megestrol acetate formulation: A Single-Dose, Randomized, Open-Label, 2-Part, 2-Period Crossover Study in Healthy Korean Subjects
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 54/9 :698-704,2016
Quantitative Model for the Blood Pressure Lowering Interaction of Valsartan and Amlodipine
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 82/6 :1,557-1,567,2016
Quantitative assessment of food effect on the pharmacokinetics of nano-crystallized megestrol acetate
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 120/3 :270-277,2017
Experience and pharmacokinetics of Levetiracetam in Korean neonates with neonatal seizures
Korean Journal of Pediatrics 60/2 :50-54,2017
A Review of Modeling Approaches to Predict Drug Response in Clinical Oncology
YONSEI MEDICAL JOURNAL 58/1 :1-8,2017
Mechanistic Model for Blood Pressure and Heart Rate Changes Produced by Telmisartan in Human Beings
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 122/1 :139-148,2018
An item response theory based integrated model of headache, nausea, photophobia, and phonophobia in migraine patients
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS 45/5 :721-731,2018
Model-based assessment of the benefits and risks of recombinant tissue plasminogen activator treatment in acute ischaemic stroke
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 84/11 :2,586-2,599,2018
A Prediction Model of Tumor Progression and Survival in HER2-Positive Metastatic Gastric Cancer Patients Treated with Trastuzumab and Chemotherapy
AAPS JOURNAL 20/4 :72-87,2018
Population PK-PD Model of Pegylated Interferon Alfa-2a in Healthy Korean Men
JOURNAL OF PHARMACEUTICAL SCIENCES 107/12 :3,171-3,178,2018
Population pharmacokinetic model of levetiracetam in Korean neonates with seizures
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 56/5 :217-223,2018
Optimal Dosing Regimen of Phenytoin for Korean Epilepsy Patients: From Premature Babies to the Elderly
JOURNAL OF PHARMACEUTICAL SCIENCES 108/8 :2,765-2,773,2019
Predicting Disease Progression in Patients with Bicuspid Aortic Stenosis Using Mathematical Modeling
Journal of Clinical Medicine 8/9 :E1302-,2019
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[KBS] ‘복제약’ 효능 믿어도 되나?…혁신이 과제 - 약리학교실 박경수...
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