이창훈

과장
    

  #뇌종양#사이버나이프 방사선 수술#암치료 #방사선 #암센터 #암진료 #암#치매진단 #중입자치료기

학력

1978 .03~1984 .02 서울대학교 의과대학 학사
1986 .03~1988 .02 서울대학교 의과대학원 석사
1992 .03~1996 .02 서울대학교 의과대학원 박사

경력

2013 .11 의료기관평가인증원 자원조사위원
2013 .07~2015 .07 한국원자력의학원 원자력병원장
2013 .04~2016 .04 대한암협회 이사
2010~2013 한국원자력의학원 의료질관리실장
2008~2009 한국원자력의학원 홍보실장
2007~2013 한국원자력의학원 사이버나이프 센터장
2004 .11~2007 .03 원자력병원 기능유전체연구실 실장
2002 .10~2004 .11 원자력병원 세포생물학연구실 실장
1992 .05 원자력병원 신경외과
1984 .03~1989 .02 서울대학교병원 수련의 및 신경외과 전공의

논문

논문 1995년도 Lee SH, Kim JH, Rhee CH, Kang YS, Lee JH, Hong SI, and Choi KS. Loss of heterozygosity on chromosome 10, 13q(Rb), 17p, and p53 gene mutations in human brain gliomas. J Korean Med Sci. 1995 Dec;10(6):442-8. -

논문 1997년도 Lee SH, Kim JH, Lee JH, Rhee CH, Cho KJ. Unusual appearance of an intracranial metastatic adenoid cystic carcinoma: comedo-necrosis showed very hyperdense nodules on CT scans. Eur J Radiol. 1997 Jul;25(1):41-3. -

논문 1998년도 Kim JH, Lee SH, Rhee CH, Park SY, Lee JH. Loss of heterozygosity on chromosome 22q and 17p correlates with aggressiveness of meningiomas. J Neurooncol. 1998 Nov;40(2):101-6. -

논문 1998년도 Shim, C., Zhang, W., Rhee, C.H., and Lee, J.H. Molecular profiling of differentially expressed genes in human cervical cancer compared with normal cervix by cDNA expression array. Clinical Cancer Res. 4:3045-3050, 1998. -

논문 1999년도 Rhee, C.H., Hess, K., Stephen Chen, James Jabbur, Yu Yang, Alex Chenchik, Fuller, G.N., and Zhang, W. Heterogeneous gene expression profiles in three human glioblastoma cell lines. Oncogene 18:2711-2717, 1999. -

논문 1999년도 Rhee, C.H., Ruan, S.B., Chen, S., Chenchik, A., Levin, V, Yung, A., Fuller, G.N., and Zhang, W. Characterization of cellular pathways involved in glioblastoma response to chemotherapeutic agent 1,3-Bis (2-chloroethyl) ? 1 - nitrosourea(BCNU) by gene expression profiling. Oncology Report. 6:393-401, 1999 -

논문 1999년도 Fuller, G.N., Rhee, C.H., Hess, K., Caskey, L., Wang, R.P, Bruner, J.,Yung, A., and Zhang, W. Reactivation of insulin-like growth factor binding protein II expression during glioblastoma transformation revealed by parallel gene expression profiling. Cancer Res. 59:4228-4232, 1999. -

논문 2000년도 Hur JH, Park MJ, Park IC, Yi DH, Rhee CH, Hong SI, Lee SH. Matrix metalloproteinases in human gliomas: activation of matrix metalloproteinase-2 (MMP-2) may be correlated with membrane-type-1 matrix metalloproteinase (MT1-MMP) expression. J Korean Med Sci. 2000 Jun;15(3):309-14. -

논문 2001년도 Hess KR, Fuller GN, Rhee CH, and Zhang W. Statistical pattern analysis of gene expression profiles of glioblastoma tissues and cell lines. Int. J. Mol Med. 8:183-8, 2001. -

논문 2002년도 Chun YJ, Park IC, Park MJ, Woo SH, Hong SI, Chung HY, Kim TH, Lee YS, Rhee CH, Lee SJ. Enhancement of radiation response in human cervical cancer cells in vitro and in vivo by arsenic trioxide (As2O3). FEBS Lett. 2002 May 22;519(1-3):195-200. -

논문 2002년도 Fuller GN, Hess KR, Rhee CH, Yung WK, Sawaya RA, Bruner JM, Zhang W. Molecular classification of human diffuse gliomas by multidimensional scaling analysis of gene expression profiles parallels morphology-based classification, correlates with survival, and reveals clinically-relevant novel glioma subsets. Brain Pathol. 2002 Jan;12(1):108-16. -

논문 2002년도 Woo SH, Park IC, Park MJ, Lee HC, Lee SJ, Chun YJ, Lee SH, Hong SI, Rhee CH. Arsenic trioxide induces apoptosis through a reactive oxygen species-dependent pathway and loss of mitochondrial membrane potential in HeLa cells. Int J Oncol. 2002 Jul;21(1):57-63. -

논문 2003년도 Park IC, Woo SH, Park MJ, Lee HC, Lee SJ, Hong YJ, Lee SH, Hong SI, Rhee CH. Ionizing radiation and nitric oxide donor sensitize Fas-induced apoptosis via up-regulation of Fas in human cervical cancer cells. Oncol Rep. 2003 May-Jun;10(3):629-33. -

논문 2003년도 Park IC, Park MJ, Woo SH, Lee HC, An S, Gwak HS, Lee SH, Hong SI, Bae IJ, Seo KM, Rhee CH. Tetraarsenic oxide induces apoptosis in U937 leukemic cells through a reactive oxygen species-dependent pathway. Int J Oncol. 2003 Oct;23(4):943-8. -

논문 2003년도 Park MJ, Park IC, Bae IJ, Seo KM, Lee SH, Hong SI, Eun CK, Zhang W, Rhee CH. Tetraarsenic oxide, a novel orally administrable angiogenesis inhibitor. Int J Oncol. 2003 Jun;22(6):1271-6. -

논문 2004년도 17. Woo SH, Park IC, Park MJ, An S, Lee HC, Jin HO, Park SA, Cho H, Lee SJ, Gwak HS, Hong YJ, Hong SI, Rhee CH. Arsenic trioxide sensitizes CD95/Fas-induced apoptosis through ROS-mediated upregulation of CD95/Fas by NF-kappaB activation. Int J Cancer. 2004 Nov 20;112(4):596-606. -

논문 2004년도 Raza SM, Fuller GN, Rhee CH, Huang S, Hess K, Zhang W, Sawaya R. Identification of necrosis-associated genes in glioblastoma by cDNA microarray analysis. Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):212-21. -

논문 2005년도 Gwak HS, Youn SM, Kwon AH, Lee SH, Kim JH, Rhee CH. ACNU-cisplatin continuous infusion chemotherapy as salvage therapy for recurrent glioblastomas: phase II study. J Neurooncol. 2005 Nov;75(2):173-80. -

논문 2005년도 Woo SH, Park MJ, An S, Lee HC, Jin HO, Lee SJ, Gwak HS, Park IC, Hong SI, Rhee CH. Diarsenic and tetraarsenic oxide inhibit cell cycle progression and bFGF- and VEGF-induced proliferation of human endothelial cells. J Cell Biochem. 2005 May 1;95(1):120-30. -

논문 2005년도 Park MJ, Lee JY, Kwak HJ, Park CM, Lee HC, Woo SH, Jin HO, Han CJ, An S, Lee SH, Chung HY, Park IC, Hong SI, Rhee CH. Arsenic trioxide (As2O3) inhibits invasion of HT1080 human fibrosarcoma cells: role of nuclear factor-kappaB and reactive oxygen species. J Cell Biochem. 2005 Aug 1;95(5):955-69. -

논문 2006년도 Park CM, Park MJ, Kwak HJ, Moon SI, Yoo DH, Lee HC, Park IC, Rhee CH, Hong SI. Induction of p53-mediated apoptosis and recovery of chemosensitivity through p53 transduction in human glioblastoma cells by cisplatin. Int J Oncol. 2006 Jan;28(1):119-25. -

논문 2006년도 Kwak HJ, Park MJ, Park CM, Moon SI, Yoo DH, Lee HC, Lee SH, Kim MS, Lee HW, Shin WS, Park IC, Rhee CH, Hong SI. Emodin inhibits vascular endothelial growth factor-A-induced angiogenesis by blocking receptor-2 (KDR/Flk-1) phosphorylation. Int J Cancer. 2006 Jun 1;118(11):2711-20. -

논문 2006년도 Kwak HJ, Park MJ, Cho H, Park CM, Moon SI, Lee HC, Park IC, Kim MS, Rhee CH, Hong SI. Transforming growth factor-beta1 induces tissue inhibitor of metalloproteinase-1 expression via activation of extracellular signal-regulated kinase and Sp1 in human fibrosarcoma cells. Mol Cancer Res. 2006 Mar;4(3):209-20. -

논문 2006년도 Park CM, Park MJ, Kwak HJ, Lee HC, Kim MS, Lee SH, Park IC, Rhee CH, Hong SI. Ionizing Radiation Enhances Matrix Metalloproteinase-2 Secretion and Invasion of Glioma Cells through Src/Epidermal Growth Factor Receptor-Mediated p38/Akt and Phosphatidylinositol 3-Kinase/Akt Signaling Pathways. Cancer Res. 2006 Sep 1;66(17):8511-8519. -

논문 2006년도 Jin HO, Yoon SI, Seo SK, Lee HC, Woo SH, Yoo DH, Lee SJ, Choe TB, An S, Kwon TJ, Kim JI, Park MJ, Hong SI, Park IC, Rhee CH. Synergistic induction of apoptosis by sulindac and arsenic trioxide in human lung cancer A549 cells via reactive oxygen species-dependent down-regulation of survivin. Biochem Pharmacol. 2006 Nov 15;72(10):1228-36. Epub 2006 Sep 6. -

논문 2006년도 Jin HO, Park IC, An S, Lee HC, Woo SH, Hong YJ, Lee SJ, Park MJ, Yoo DH, Rhee CH, Hong SI. Up-regulation of Bak and Bim via JNK downstream pathway in the response to nitric oxide in human glioblastoma cells. J Cell Physiol. 2006 Feb;206(2):477-86. -

논문 2006년도 Gwak HS, Yoo HJ, Youn SM, Chang U, Lee DH, Yoo SY, Rhee CH. Hypofractionated Stereotactic Radiation Therapy for Skull Base and Upper Cervical Chordoma and Chondrosarcoma: Preliminary Results. Stereotact Funct Neurosurg. 2006 Mar 13;83(5-6):233-243. -

논문 2006년도 Gwak HS, Yoo HJ, Youn SM, Chang U, Lee DH, Yoo SY, Rhee CH. Hypofractionated stereotactic radiation therapy for skull base and upper cervical chordoma and chondrosarcoma: preliminary results. Stereotact Funct Neurosurg. 2005;83(5-6):233-43. Epub 2006 Mar 13. -

논문 2006년도 Gwak HS, Youn SM, Chang U, Lee DH, Cheon GJ, Rhee CH, Kim K, Kim HJ. Usefulness of (18)F-fluorodeoxyglucose PET for radiosurgery planning and response monitoring in patients with recurrent spinal metastasis. Minim Invasive Neurosurg. 2006 Jun;49(3):127-34. -

논문 2007년도 Park MJ, Kwak HJ, Lee HC, Yoo DH, Park IC, Kim MS, Lee SH, Rhee CH, Hong SI. Nerve growth factor induces endothelial cell invasion and cord formation by promoting matrix metalloproteinase-2 expression through the phosphatidylinositol 3-kinase/Akt signaling pathway and AP-2 transcription factor.J Biol Chem. 2007 Oct 19;282(42):30485-96. -

논문 2007년도 Seo SK, Lee HC, Woo SH, Jin HO, Yoo DH, Lee SJ, An S, Choe TB, Park MJ, Hong SI, Park IC, Rhee CH. Sulindac-derived reactive oxygen species induce apoptosis of human multiple myeloma cells via p38 mitogen activated protein kinase-induced mitochondrial dysfunction. Apoptosis. 2007 Jan;12(1):195-209. -

논문 2007년도 Jin HO, An S, Lee HC, Woo SH, Seo SK, Choe TB, Yoo DH, Lee SB, Um HD, Lee SJ, Park MJ, Kim JI, Hong SI, Rhee CH, Park IC. Hypoxic condition- and high cell density-induced expression of Redd1 is regulated by activation of hypoxia-inducible factor-1alpha and Sp1 through the phosphatidylinositol 3-kinase/Akt signaling pathway. Cell Signal. 2007 Jul;19(7):1393-403. -

논문 2008년도 Seo SK, Jin HO, Lee HC, Woo SH, Kim ES, Yoo DH, Lee SJ, An S, Rhee CH, Hong SI, Choe TB, Park IC. Combined effects of sulindac and suberoylanilide hydroxamic acid on apoptosis induction in human lung cancer cells. Mol Pharmacol. 2008 Mar;73(3):1005-12. -

논문 2008년도 Jin HO, Seo SK, Woo SH, Lee HC, Kim ES, Yoo DH, Lee SJ, An S, Choe TB, Kim JI, Hong SI, Rhee CH, Park IC. A combination of sulindac and arsenic trioxide synergistically induces apoptosis in human lung cancer H1299 cells via c-Jun NH2-terminal kinase-dependent Bcl-xL phosphorylation. Lung Cancer. 2008 Sep;61(3):317-27. -

논문 2008년도 Lee HC, An S, Lee H, Woo SH, Jin HO, Seo SK, Choe TB, Yoo DH, Lee SJ, Hong YJ, Park MJ, Rhee CH, Park IC, Hong SI. Activation of epidermal growth factor receptor and its downstream signaling pathway by nitric oxide in response to ionizing radiation. Mol Cancer Res. 2008 Jun;6(6):996-1002. -

논문 2009년도 Woo SH, An S, Lee HC, Jin HO, Seo SK, Yoo DH, Lee KH, Rhee CH, Choi EJ, Hong SI, Park IC. A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function. J Biol Chem. 2009 Nov 6;284(45):30871-80. -

논문 2009년도 Chang UK, Youn SM, Park SQ, Rhee CH. Clinical results of cyberknife(r) radiosurgery for spinal metastases. J Korean Neurosurg Soc. 2009 Dec;46(6):538-44. -

논문 2009년도 Jin HO, Seo SK, Woo SH, Kim ES, Lee HC, Yoo DH, An S, Choe TB, Lee SJ, Hong SI, Rhee CH, Kim JI, Park IC. Activating transcription factor 4 and CCAAT/enhancer-binding protein-beta negatively regulate the mammalian target of rapamycin via Redd1 expression in response to oxidative and endoplasmic reticulum stress. Free Radic Biol Med. 2009 Apr 15;46(8):1158-67. -

논문 2009년도 Gwak HS, Yoo HJ, Youn SM, Lee DH, Kim MS, Rhee CH. Radiosurgery for recurrent brain metastases after whole-brain radiotherapy : factors affecting radiation-induced neurological dysfunction. J Korean Neurosurg Soc. 2009 May;45(5):275-83.

저서

저서 내용이 없습니다.

보도자료

[뉴시스] 노원구청-원자력병원 업무협약 체결
https://newsis.com/pict_detail/view.html?pict_id=NISI20150202_0010590192

포스팅

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영상자료

[MBC] [우리 아이들] "엄마약속 믿어요"
http://news.naver.com/main/read.nhn?mode=LSD&mid=sec&sid1=001&oid=214&aid=0000003139

[원자력병원] 암은 원자력병원입니다.-사이버나이프-신경외과 이창훈 과장
https://youtu.be/mme49RZ2b7Y

발표자료

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