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  #노년우울증#치매

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서울대학교 의과대학 의학박사

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(前) 서울대학교병원신경정신과 교수
(前) 스웨덴 카롤린스카의학원 방문교수
(現) 조선대학교 의과대학 정신건강의학과 교수
(前) 조선대학교병원 정신건강의학과 과장
(現) 광주광역시 광역치매센터장

논문

1. Choo IH. Comparison of Two Multi-Step Programs for Early Detection of Amnestic Mild Cognitive Impairment in the Community. Journal of Korean Geriatric Psychiatry 2020;24(1):10-16.

2. Choo IH, Chong A, Chung JY, Kim H. Association of Subjective Memory Complaints with the Left Parahippocampal Amyloid Burden in Mild Cognitive Impairment. J Alzheimers Dis. 2019;72(4):1261-1268.

3. Altomare D, Ferrari C, Caroli A, Galluzzi S, Prestia A, van der Flier WM, Ossenkoppele R, Van Berckel B, Barkhof F, Teunissen CE, Wall A, Carter SF, Scholl M, Choo IH, Grimmer T, Redolfi A, Nordberg A, Scheltens P, Drzezga A, Frisoni GB; Alzheimer’s Disease Neuroimaging Initiative. Prognostic value of Alzheimer's biomarkers in mild cognitive impairment: the effect of age at onset. J Neurol. 2019 Oct;266(10):2535-2545.

4. Seo EH, Kim H, Choi KY, Lee KH, Choo IH. Pre-Mild Cognitive Impairment: Can Visual Memory Predict Who Rapidly Convert to Mild Cognitive Impairment? Psychiatry Investig. 2018 Sep;15(9):869-875

5. Seo EH, Kim H, Choi KY, Lee KH, Choo IH. Association of subjective memory complaint and depressive symptoms with objective cognitive functions in prodromal Alzheimer's disease including pre-mild cognitive impairment. J Affect Disord. 2017;217:24-28

6. Seo EH, Park WY, Choo IH. Structural MRI and Amyloid PET Imaging for Prediction of Conversion to Alzheimer's Disease in Patients with Mild Cognitive Impairment: A Meta-Analysis. Psychiatry Investig. 2017;14(2):205-215

7. Seo EH, Kim H, Lee KH, Choo IH. Altered Executive Function in Pre-Mild Cognitive Impairment. J Alzheimers Dis. 2016:54(3):933-940

8. Seo EH, Kim SH, Park SH, Kang SH, Choo IH; Alzheimer’s Disease Neuroimaging Initiative. Topographical APOE ?4 Genotype Influence on Cerebral Metabolism in the Continuum of Alzheimer's Disease: Amyloid Burden Adjusted Analysis. J Alzheimers Dis. 2016;54(2):559-68

9. Seo EH, Choo IH; Alzheimer's Disease Neuroimaging Initiative. Amyloid-independent functional neural correlates of episodic memory in amnestic mild cognitive impairment. Eur J Nucl Med Mol Imaging. 2016: 43(6):1088-95

10. Seo EH, Kim SH, Park SH, Kang SH, Choo IH; Alzheimer's Disease Neuroimaging Initiative. Independent and Interactive Influences of the APOE Genotype and Beta-Amyloid Burden on Cognitive Function in Mild Cognitive Impairment. J Korean Med Sci. 2016 Feb;31(2):286-95

11. Jang H, Kim SH, Park SH, Choo IH, Kim SG. Psychiatric symptoms in temporal lobe epilepsy with left mesial hippocampal sclerosis. Psychiatry Investig. 2015 Apr;12(2):274-7

12. Prestia A, Caroli A, Wade SK, van der Flier WM, Ossenkoppele R, Van Berckel B, Barkhof F, Teunissen CE, Wall A, Carter SF, Scholl M, Choo IH, Nordberg A, Scheltens P, Frisoni GB. Prediction of AD dementia by biomarkers following the NIA-AA and IWG diagnostic criteria in MCI patients from three European memory clinics. Alzheimers Dement. 2015 Oct;11(10):1191-201

13. Caroli A, Prestia A, Galluzzi S, Ferrari C, van der Flier WM, Ossenkoppele R, Van Berckel B, Barkhof F, Teunissen C, Wall AE, Carter SF, Scholl M, Choo IH, Grimmer T, Redolfi A, Nordberg A, Scheltens P, Drzezga A, Frisoni GB; Alzheimer's Disease Neuroimaging Initiative. Mild cognitive impairment with suspected nonamyloid pathology (SNAP): Prediction of progression. Neurology. 2015 Feb 3;84(5):508-15

14. Choo J, Turk MT, Jae SY, Choo IH. Factors associated with health-related quality of life among overweight and obese Korean women. Women Health. 2015 Feb-Mar;55(2):152-66

15. Kim Y, Tae J, Lee K, Rhim H, Choo IH, Cho H, Park WK, Keum G, Choo H. Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression. Bioorg Med Chem. 2014 Sep 1;22(17):4587-96

16. Kim Y, Kim J, Kim S, Ki Y, Seo SH, Tae J, Ko MK, Jang HS, Lim EJ, Song C, Cho Y, Koh HY, Chong Y, Choo IH, Keum G, Min SJ, Choo H. Novel thienopyrimidinones as mGluR1 antagonists. Eur J Med Chem. 2014 Oct 6;85:629-37

17. Choo IH, Carter SF, Scholl M, Nordberg A. Astrocytosis measured by 11C-deprenyl PET correlates with decrease in gray matter density in parahippocampus of prodromal Alzheimer patients. Eur J Nucl Med Mol Imaging 2014 Nov;41(11):2120-6

18. Cho JH, Jae SY, Choo IH, Choo J. Health-promoting behaviour among women with abdominal obesity: a conceptual link to social support and perceived stress. J Adv Nurs. 2014 Jun;70(6):1381-90

19. Kim JW, Lee DY, Seo EH, Sohn BK, Choe YM, Kim SG, Park SY, Choo IH, Youn JC, Jhoo JH, Kim KW, Woo JI. Improvement of Screening Accuracy of Mini-Mental State Examination for Mild Cognitive Impairment and Non-Alzheimer's Disease Dementia by Supplementation of Verbal Fluency Performance. Psychiatry Investig. 2014;11(1):44-51

20. Kim JW, Lee DY, Seo EH, Sohn BK, Park SY, Choo IH, Youn JC, Jhoo JH, Kim KW, Woo JI. Improvement of dementia screening accuracy of mini-mental state examination by education-adjustment and supplementation of frontal assessment battery performance. J Korean Med Sci. 2013;28(10):1522-8

21. Choo IH, Ni R, Scholl M, Wall A, Almkvist O, Nordberg A. Combination of (18)F-FDG PET and cerebrospinal fluid biomarkers as a better predictor of the progression to Alzheimer's disease in mild cognitive impairment patients. J Alzheimers Dis. 2013;33(4):929-39

22. Prestia A, Caroli A, van der Flier WM, Ossenkoppele R, Van Berckel B, Barkhof F, Teunissen CE, Wall AE, Carter SF, Scholl M, Choo IH, Nordberg A, Scheltens P, Frisoni GB. Prediction of dementia in MCI patients based on core diagnostic markers for Alzheimer disease.Neurology. 2013Mar12;80(11):1048-1056

23. Park JI, Choo IH, Kim SG, Park SH, Park WY, Hwang GH, Kim SH. Violence Frequency by Sexual Assault Characteristics. J Korean Neuropsychiatr Assoc 2013:52(5);360-364

24. Kim J, Kim Y, Tae J, Yeom M, Moon B, Huang X-P, Roth BL, Lee K, Rhim H, Choo IH, Chong Y, Keum G, Nam G, Choo H. Aryl Biphenyl-3-ylmethylpiperazines as 5-HT7 Receptor Antagonists. ChemMedChem 2013:8;1855-1864

25. Park HR, Kim J, Kim T, Jo S, Yeom M, Moon B, Choo IH, Lee J, Lim EJ, Park KD, Min SJ, Nam G, Keum G, Lee CJ, Choo H. Oxazolopyridines and thiazolopyridines as monoamine oxidase B inhibitors for the treatment of Parkinson's disease. Bioorg Med Chem 2013;21:5480-5487

26. Park WY, Park SH, Kim SH, Kim SG, Park JI, Choo IH. Influences of injury severity and age on severe anxiety in posttraumatic stress disorder patients with no previous history of psychiatric disorders. Anxiety and Mood 2013;9(1):1-7

27. Ryu SH, Kim KW, Kim S, Park JH, Kim TH, Jeong HG, Kim JL, Moon SW, Bae JN, Yoon JC, Choo IH, Lee DW, Chang SM, Jhoo JH, Kim SK, Cho MJ. Normative study of the category fluency test (CFT) from nationwide data on community-dwelling elderly in Korea. Arch Gerontol Geriatr. 2012;54(2):305-9

28. Choo IH, Lee DY, Kim JW, Seo EH, Lee DS, Kim YK, Yoon EJ, Kim SG, Park SY, Kim KW, Woo JI. Relationship of amyloid-beta burden with age-at-onset in Alzheimer’s disease. Am J Geriatr Psychiatry 2011;19(7):627-34

29. Kim JW, Lee DY, Choo IH, Seo EH, Kim SG, Park SY, Woo JI. Microstructural alteration of the anterior cingulum is associated with apathy in Alzheimer disease. Am J Geriatr Psychiatry 2011;19(7):644-53

30. Youn JC, Lee DY, Jhoo JH, Kim KW, Choo IH, Woo JI. Prevalence of neuropsychiatric syndromes in Alzheimer's disease (AD). Arch Gerontol Geriatr 2011;52(3):258-63

31. Seo EH, Lee DY, Kim SG, Kim KW, Kim do H, Kim BJ, Kim MD, Kim SY, Kim YH, Kim JL, Kim JW, Moon SW, Park JH, Ryu SH, Yoon JC, Lee NJ, Lee CU, Jhoo JH, Choo IH, Woo JI. Validity of the telephone interview for cognitive status (TICS) and modified TICS (TICSm) for mild cognitive imparment (MCI) and dementia screening. Arch Gerontol Geriatr. 2011;52(1):e26-30

32. Choo IH, Lee DY, Oh JS, Lee JS, Lee DS, Song IC, Youn JC, Kim SG, Kim KW, Jhoo JH, Woo JI. Posterior cingulate cortex atrophy and regional cingulum disruption in mild cognitive impairment and Alzheimer's disease. Neurobiol Aging. 2010;31(5):772-9

33. Jhoo JH, Lee DY, Choo IH, Seo EH, Oh JS, Lee JS, Lee DS, Kim SG, Youn JC, Kim KW, Woo JI. Discrimination of normal aging, MCI and AD with multimodal imaging measures on the medial temporal lobe. Psychiatry Res 2010;183(3):237-243

34. Seo EH, Lee DY, Lee JH, Choo IH, Kim JW, Kim SG, Park SY, Shin JH, Do YJ, Yoon JC, Jhoo JH, Kim KW, Woo JI. Total Scores of the CERAD Neuropsychological Assessment Battery: Validation for Mild Cognitive Impairment and Dementia Patients with Diverse Etiologies. Am J Geriatr Psychiatry 2010;18(9):807-809

35. Lee HS, Choo IH, Lee DY, Kim JW, Seo EH, Kim SG, Park SY, Shin JH, Kim KW, Woo JI. Frontal dysfunction underlies depression in mild cognitive impairment: A FDG-PET Study. Psychiatry Investig 2010;7(3):208-214

36. Han JW, Kim TH, Jhoo JH, Park JH, Kim JL, Ryu SH, Moon SW, Choo IH, Lee DW, Yoon JC, Do YJ, Lee SB, Kim MD, Kim KW. A Normative study of the Mini-Mental State Examination for dementia screening (MMSE-DS) and its short form (SMMSE-DS) in the Korean Elderly. J Korean Geriatr Psychiatry. 2010;14(1):1-11

37. Kim TH, Jhoo JH, Park JH, Kim JL, Ryu SH, Moon SW, Choo IH, Lee DW, Yoon JC, Do YJ, Lee SB, Kim MD, Kim KW. Korean version of mini mental status examination for dementia screening and its' short form. Psychiatry Investig. 2010;7(1):102-108

38. Park HR, Kim MK, Kim DW, Choo IH, Chong YH. 3D QSAR CoMFA study on phenylthiazolylhydrazide (PTH) derivatives as tau protein aggregation inhibitors. Bull Korean Chem Soc 2010;31(12):3838-3841

39. Lee SB, Kim KW, Youn JC, Park JH, Lee JJ, Kim MH, Choi EA, Jhoo JH, Choo IH, Lee DY, Woo JI. Prevalence of mild cognitive impairment and its subtypes are influenced by the application of diagnostic criteria: results from the Korean Longitudinal Study on Health and Aging (KLoSHA). Dement Geriatr Cogn Disord. 2009;28(1):23-9.

40. Kim KW, Choi EA, Lee SB, Park JH, Lee JJ, Huh Y, Youn JC, Jhoo JH, Choo IH, Kim MH, Lee DY, Woo JI. Prevalence and neuropsychiatric comorbidities of alcohol use disorders in an elderly Korean population. Int J Geriatr Psychiatry. 2009;24(12):1420-8

41. Choo IH, Lee DY, Lee JH, Kim KW, Jhoo JH, Ju YS, Yoon JC, Kim SG, Ha J, Woo JI. The prevalence of cognitive impairment with no dementia in older people: the Seoul study. Int J Geriatr Psychiatry. 2009;24(3):306-12

42. Kim SG, Lee DY, Seo EH, Choo IH, Kim JW, Do YJ, Kim KW, Jhoo JH, Yoon JC, Park SY, Woo JI. A Normative study of an executive clock drawing task (CLOX) in Korean Elderly. J Korean Neuropsychiatr Assoc 2009;48(6):437-446

43. Youn JC, Kim KW, Lee DY, Jhoo JH, Lee SB, Park JH, Choi EA, Choe JY, Jeong JW, Choo IH, Woo JI. Development of the Subjective Memory Complaints Questionnaire. Dement Geriatr Cogn Disord. 2009;27(4):310-7

44. Han KS, Choo JA, Oh YJ, Choo IH. The level of perceived stress of life events and its correlates for community-dwelling adults in Korea. Stress Research 2009;17(2):91-98

45. Choo IH. Early detection of Alzheimer’s disease using neuroimaging: Focus on recent MRI and PET studies. J Korean Geriatr Psychiatry 2008;12:11-6

46. Seo EH, Lee DY, Choo IH, Kim SG, Kim KW, Youn JC, Jhoo JH, Woo JI. Normative study of the Stroop Color and Word Test in an educationally diverse elderly population. Int J Geriatr Psychiatry. 2008 Oct;23(10):1020-7

47. Lee DY, Seo EH, Choo IH, Kim SG, Lee JS, Lee DS, Jhoo JH, Kim KW, Youn JC, Woo JI. Neural Correlates of the Clock Drawing Test Performance in Alzheimer's Disease: A FDG-PET Study. Dement Geriatr Cogn Disord. 2008;26(4):306-313

48. Jhoo JH, Kim KW, Huh Y, Lee SB, Park JH, Lee JJ, Choi EA, Han C, Choo IH, Youn JC, Lee DY, Woo JI. Prevalence of dementia and its subtypes in an elderly urban korean population: results from the Korean Longitudinal Study on Health And Aging (KLoSHA). Dement Geriatr Cogn Disord. 2008;26(3):270-6

49. You YS, Choi SJ, Jung SS, Kim JE, Yoon SW, Jeon DW, Baek JH, Park SW, Lee JG, Choo IH, Kim YH. A correlation between neurocognitive impairments and serum lipid levels among the Korean elderly. J Korean Neuropsychiatr Assoc 2008;47(6):540-547

50. Kim KW, Youn JC, Han MK, Paik NJ, Lee TJ, Park JH, Lee SB, Choo IH, Lee DY, Jhoo JH, Woo JI. Lack of association between apolipoprotein E polymorphism and vascular dementia in Koreans. J Geriatr Psychiatry Neurol. 2008 Mar;21(1):12-7

51. Youn JC, Lee DY, Lee JH, Kim KW, Jhoo JH, Choo IH, Paek YS, Jeon YH, Seo KW, Woo JI. Development of a Korean version of the behavior rating scale for dementia (BRSD-K). Int J Geriatr Psychiatry. 2008 Jul;23(7):677-84

52. Lee HS, Kim MK, Lee CW, Kim JY, Choo IH, Woo JI, Chong YH. Chemometric studies on brain-uptake of PET agents via VolSurf analysis. Bull Korean Chem Soc. 2008;29(1):61-68.

53. Choo IH, Lee DY, Youn JC, Jhoo JH, Kim KW, Lee DS, Lee JS, Woo JI. Topographic patterns of brain
functional impairment progression according to clinical severity staging in 116 Alzheimer disease patients: FDG-PET study. Alzheimer Dis Assoc Disord. 2007;21(2):77-84

54. Kim MK, Choo IH, Lee HS, Woo JI, Chong YH. 3D-QSAR of PET agents for imaging β-amyloid in Alzheimer's disease. Bull Korean Chem Soc. 2007;28(7):1231-1234

55. Seo EH, Lee DY, Choo IH, Youn JC, Kim KW, Woo JI. A normative study of the Benton Visual Retention Test in the Korean Elderly. The Korean Journal of Clinical Psychology. 2007;26(3):745-763

56. Park JH, Lee SB, Lee TJ, Lee DY, Jhoo JH, Youn JC, Choo IH, Choi EA, Jeong JW, Choe JY, Woo JI, Kim KW. Depression in vascular dementia is quantitatively and qualitatively different from depression in Alzheimer's disease. Dement Geriatr Cogn Disord. 2007;23:67-73.

57. Seo EH, Lee DY, Choo IH, Youn JC, Kim KW, Jhoo JH, Suh KW, Paek YS, Jun YH, Woo JI. Performance on the benton visual retention test in an educationally diverse elderly population. J Gerontol B Psychol Sci Soc Sci. 2007 May;62(3):191-3.

58. Lee JH, Kim SJ, Lee DY, Choo IH, Kim KW, Youn JC, Woo JI. Relationship of sleep factors with
neurocogntive function in normal elderly subjects and mild cognitive impairment (MCI) patients. J Korean Neuropsychatr Assoc. 2007;46:41-49

59. Seo EH, Park HH, Lee DY, Choo IH, Lee JH, Chung SH, Youn JC, Kim KW, Jhoo JH, Kim SG, Woo JI. A comparison of five scoring methods of clock drawing test for Alzheimer's disease screening. The Korean Journal of Psychopathology. 2006;15:19-26

60. Lee DY, Choo IH, Jhoo JH, Kim KW, Youn JC, Lee DS, Kang EJ, Lee JS, Kang WJ, Woo JI. Frontal dysfunction underlies depressive syndrome in Alzheimer’s disease: A FDG-PET study. Am J Geriatr Psychiatry. 2006;14(7):625-628

61. Lee DY, Choo IH, Kim KW, Jhoo JH, Youn JC, Lee UY, Woo JI. White matter changes are associated with psychotic symptoms in Alzheimer’s disease patients. J Neuropsychiatry Clin Neurosci. 2006;18(2):191-198

62. Lee DY, Youn JC, Choo IH, Kim KW, Jhoo JH, Pak YS, Suh KW, Woo JI. Combination of clinical and neuropsychological information as a better predictor of the progression to Alzheimer’s disease in questionable dementia individuals. Am J Geriatr Psychiatry. 2006;14(2):130-138

63. Suh YJ, Kim KW, Jhoo JH, Lee DY, Youn JC, Paek YS, Choo IH, Lee JH, Woo JI. Application of stochastic search variable selection to genetic association studies in common complex diseases. Korean J Genetics. 2006;28(3):287-294.

64. Seo EH, Lee DY, Kim KW, Lee JH, Jhoo JH, Youn JC, Choo IH, Ha J, Woo JI. A normative study of the Trail Making Test in Korean elders. Int J Geriatr Psychiatry. 2006 Sep;21(9):844-52.

65. Jhoo JH, Park WY, Kim KW, Lee KH, Lee DY, Youn JC, Choo IH, Seo JS, Woo JI. Lack of association of
cathepsin D genetic polymorphism with Alzheimer's disease in Koreans. Arch Gerontol Geriat. 2005;41(2):121-127.

66. Jhoo JH, Kim KW, Lee DY, Youn JC, Lee TJ, Choo IH, Ko HJ, Seo EH, Woo JI. Comparison of the performance in two different Korean versions of Mini-mental state examination: MMSE-KC and K-MMSE. J Korean Neuropsychiatr Assoc. 2005;44(1): 98-104.

67. Choo IH, Kim JS, Hong SC, Han JH, Lee SP. The Effect of Electroconvulsive Shock on Chloramphenicol-Induced Insomnia in Freely-Moving Rats. J Korean Neuropsychiatr Assoc. 1999;38(5):1170-1177.

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[의학 칼럼] 치매 막는 생활습관
https://www.jnilbo.com/view/media/view?code=20160303000000491112422

치매 환자, 20년마다 2배 가량 증가
http://www.mdtoday.co.kr/mdtoday/index.html?no=249502

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