심효섭

  #폐병리#분자병리

학력

연세대학교 의과대학 학사 (2000)
연세대학교 의과대학 석사 (2003)
연세대학교 의과대학 박사 (2009)

경력

세브란스병원 전공의 (2001-2005)
공군 군의관 (2005-2008)
연세대학교 의과대학 강사, 임상조교수 (2008-2010)
Massachusetts General Hospital, Molecular Pathology, Research Fellow (2013-2015)

논문

Increased expression of matrix metalloproteinase 9 correlates with poor prognostic variables in renal cell carcinoma
EUROPEAN UROLOGY 44/5 :560-566,2003

Prognostic significance of paired epithelial cell adhesion molecule and E-cadherin in ovarian serous carcinoma
Human Pathology 40/5 :693-698,2009

Glassy Cell Carcinoma Predominantly Commits to a Squamous Lineage and is Strongly Associated With High-risk Type Human Papillomavirus Infection
International Journal Of Gynecological Pathology 28/4 :389-395,2009

Prognostic significance of visceral pleural invasion in the forthcoming (seventh) edition of TNM classification for lung cancer
Lung Cancer 65/2 :161-165,2009

흉막에 생긴 다발성 석회화 섬유성 가종양 ?1예 보고?
Korean Journal Of Thoracic And Cardiovascular Surgery(대한흉부외과학회지) 42/5 :666-669,2009

기관에 생긴 사구 종양 -1예 보고-
Korean Journal Of Thoracic And Cardiovascular Surgery(대한흉부외과학회지) 42/4 :540-542,2009

Molecular Proteomics Imaging of Tumor Interfaces by Mass Spectrometry
Journal of Proteome Research 9/2 :1157-1164,2010

궤양성 대장염에서 나타난 폐쇄성 세기관지염 기질화 폐렴 1예
Tuberculosis And Respiratory Diseases(결핵 및 호흡기질환) 68/3 :175-179,2010

Histopathologic findings of transbronchial biopsy in usual interstitial pneumonia
Pathology International 60/5 :373-377,2010

Adenocarcinoma of the small bowel at a single Korean institute: management and prognosticators
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 136/3 :387-394,2010
Pulmonary Involvement of Peripheral T-cell Lymphoma, Unspecified: A Case Report
대한영상의학회지 62/1 :37-40,2010

Dose effect of cigarette smoking on frequency and spectrum of epidermal growth factor receptor gene mutations in Korean patients with non-small cell lung cancer
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 136/12 :1937-1944,2010

고립성 폐결절로 발현된 비결핵성 마이코박테리움 폐질환 1예
Tuberculosis And Respiratory Diseases(결핵 및 호흡기질환) 69/1 :43-47,2010

Use of Contrast Enhancement and High-Resolution 3D Black-Blood MRI to Identify Inflammation in Atherosclerosis
JACC-CARDIOVASCULAR IMAGING 3/11 :1127-1135,2010

Detection of sexually transmitted infection and human papillomavirus in negative cytology by multiplex-PCR
Bmc Infectious Diseases 10/ :284-291,2010

A phase I study of nimotuzumab in combination with radiotherapy in stages IIB-IV non-small cell lung cancer unsuitable for radical therapy: Korean results
LUNG CANCER 71/1 :55-59,2011

Diffuse Interstitial Infiltrative Lung Metastasis of Malignant Melanoma: a Case Report
KOREAN JOURNAL OF RADIOLOGY 12/2 :252-255,2011

Molecular portraits of intratumoral heterogeneity in human ovarian cancer
CANCER LETTERS 307/1 :62-71,2011
다발성 폐결절로 발견된 카플란증후군 1예
Tuberculosis and Respiratory Diseases 70/2 :150-154,2011

Prognostic effect of stromal lymphocyte infiltration in thrymic carcinoma
LUNG CANCER 74/2 :338-343,2011

Application of tissue microarray for atherectomized tissues from peripheral arterial disease
PATHOLOGY RESEARCH AND PRACTICE 207/9 :568-572,2011

PROGNOSTIC FACTORS FOR IDIOPATHIC PULMONARY FIBROSIS: CLINICAL, PHYSIOLOGIC, PATHOLOGIC, AND MOLECULAR ASPECTS
SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES 28/2 :102-112,2011

Prognostic effect of stromal lymphocyte infiltration in thrymic carcinoma
LUNG CANCER 74/ :338-343,2011

Distinct clinical features and outcomes in never-smokers with nonsmall cell lung cancer who harbor EGFR or KRAS mutations or ALK rearrangement
CANCER 118/3 :729-739,2012

High EGFR gene copy number and skin rash as predictive markers for EGFR tyrosine kinase inhibitors in patients with advanced squamous cell lung carcinoma
CLINICAL CANCER RESEARCH 18/6 :1760-1768,2012

Optimal combination of immunohistochemical markers for subclassification of non-small cell lung carcinomas: A tissue microarray study of poorly differentiated areas
LUNG CANCER 76/1 :51-55,2012

Assessment of atherosclerotic plaques in a rabbit model by delayed-phase contrast-enhanced CT angiography: comparison with histopathology
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING 28/2 :353-363,2012

Pulmonary sclerosing haemangioma with metastatic spread to stomach.
HISTOPATHOLOGY 60/7 :1162-1164,2012

Napsin A is an independent prognostic factor in surgically resected adenocarcinoma of the lung
LUNG CANCER 77/1 :156-161,2012

A phase I trial of gefitinib and nimotuzumab in patients with advanced non-small cell lung cancer (NSCLC)
LUNG CANCER 79/3 :270-275,2013

Fibroblast Growth Factor Receptor 1 Gene Amplification Is Associated With Poor Survival and Cigarette Smoking Dosage in Patients With Resected Squamous Cell Lung Cancer.
JOURNAL OF CLINICAL ONCOLOGY 31/6 :731-737,2013

Image analysis of peripheral compression artefacts of ThinPrep? liquid-based cytology preparations
CYTOPATHOLOGY 24/2 :99-104,2013

Role of FGF receptors as an emerging therapeutic target in lung squamous cell carcinoma.
FUTURE ONCOLOGY 9/3 :377-386,2013

Guideline recommendations for EGFR mutation testing in lung cancer: Proposal of the korean cardiopulmonary pathology study group
KOREAN JOURNAL OF PATHOLOGY 47/2 :100-106,2013

Analysis of tumor markers in cytological fluid obtained from computed tomographyguided needle aspiration biopsies for the diagnosis of ground-glass opacity pulmonary lesions
CANCER CYTOPATHOLOGY 121/4 :214-222,2013

TGF-b1 T869C Polymorphism May Affect Susceptibility to Idiopathic Pulmonary Fibrosis and Disease Severity
LUNG 191/2 :199-205,2013

The frequency and impact of ROS1 rearrangement on clinical outcomes in never smokers with lung adenocarcinoma
ANNALS OF ONCOLOGY 24/9 :2364-2370,2013

EGFR and TTF-1 Gene Amplification in Surgically Resected Lung Adenocarcinomas: Clinicopathologic Significance and Effect on Response to EGFR-Tyrosine Kinase Inhibitors in Recurred Cases
ANNALS OF SURGICAL ONCOLOGY 20/9 :3015-3022,2013

NSCLC Subtype Prediction Using Cytologic Fluid Specimens From Needle Aspiration Biopsies
AMERICAN JOURNAL OF CLINICAL PATHOLOGY 139/3 :309-316,2013

Taurolidine: A New Alternative Agent for the Management of the Postoperative Air Leak
ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY 19/ :6-11,2013

Prediction for response duration to epidermal growth factor receptor-tyrosine kinase inhibitors in EGFR mutated never smoker lung adenocarcinoma
LUNG CANCER 83/3 :374-382,2014

Multifocal micronodular pneumocyte hyperplasia mimicking miliary tuberculosis.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 189/2 :225-226,2014

Clinical and prognostic implications of ALK and ROS1 rearrangements in never-smokers with surgically resected lung adenocarcinoma
LUNG CANCER 83/3 :389-395,2014

A single-tube multiplexed assay for detecting ALK, ROS1, and RET fusions in lung cancer
JOURNAL OF MOLECULAR DIAGNOSTICS 16/2 :229-243,2014

Tumor perfusion-related parameter of diffusion-weighted magnetic resonance imaging: Correlation with histological microvessel density
MAGNETIC RESONANCE IN MEDICINE 71/4 :1554-1558,2014

Detailed pathologic evaluation on endomyocardial biopsy provides long-term prognostic information in patients with acute myocarditis
CARDIOVASCULAR PATHOLOGY 23/3 :139-144,2014

Guideline Recommendations for Testing of ALK Gene Rearrangement in Lung Cancer: A Proposal of the Korean Cardiopulmonary Pathology Study Group
KOREAN JOURNAL OF PATHOLOGY 48/1 :1-9,2014

KRAS oncogene substitutions in Korean NSCLC patients: Clinical implication and relationship with pAKT and RalGTPases expression
LUNG CANCER 85/2 :299-305,2014

Cervical ganglion block attenuates the progression of pulmonary hypertension via nitric oxide and arginase pathways
HYPERTENSION 63/2 :309-315,2014

Identification of somatic mutations in EGFR/KRAS/ALK-negative lung adenocarcinoma in never-smokers
GENOME MEDICINE 6/18 :1-10,2014

Screening of ROS1 rearrangements in lung adenocarcinoma by immunohistochemistry and comparison with ALK rearrangements
PLOS ONE 9/Issue 7 :e103333-,2014

Anchored multiplex PCR for targeted next-generation sequencing
NATURE MEDICINE 20/12 :1479-1484,2014

Prognostic effect of matrix metalloproteinase-9 in patients with resected Non small cell lung cancer
JOURNAL OF CARDIOTHORACIC SURGERY 10/1 :0-0,2015

The frequency and impact of FGFR1 amplification on clinical outcomes in Korean patients with small cell lung cancer
LUNG CANCER 88/3 :325-331,2015

Unique Genetic and Survival Characteristics of Invasive Mucinous Adenocarcinoma of the Lung
JOURNAL OF THORACIC ONCOLOGY 10/8 :1156-1162,2015

LAMC2 enhances the metastatic potential of lung adenocarcinoma
CELL DEATH AND DIFFERENTIATION 22/8 :1341-1352,2015

Autophagy contributes to the chemo-resistance of non-small cell lung cancer in hypoxic conditions.
RESPIRATORY RESEARCH 9/16 :138-,2015

Time, Dose, and Volume Responses in a Mouse Pulmonary Injury Model Following Ablative Irradiation
LUNG 194/1 :81-90,2016

Transforming Growth Factor-Beta 1 in Humidifier Disinfectant-Associated Children's Interstitial Lung Disease
PEDIATRIC PULMONOLOGY 51/2 :173-182,2016

A multicenter phase II study of sorafenib in combination with erlotinib in patients with advanced non-small cell lung cancer (KCSG-0806)
LUNG CANCER 93/0 :1-8,2016

Correlation between EGFR gene mutation, cytologic tumor markers, 18F-FDG uptake in non-small cell lung cancer
BMC CANCER 16/1 :224-,2016

Prognostic impact of cytological fluid tumor markers in non-small cell lung cancer
TUMOR BIOLOGY 37/3 :3205-3213,2016

A Case of ALK-Rearranged Adenocarcinoma with Small Cell Carcinoma-Like Transformation and Resistance to Crizotinib
JOURNAL OF THORACIC ONCOLOGY 11/5 :e55-e58,2016

Met exon 14 skipping in non-small cell lung cancer
ONCOLOGIST 21/4 :481-486,2016

Clinicopathological and prognostic significance of programmed cell death ligand-1 expression in lung adenocarcinoma and its relationship with p53 status
LUNG CANCER 97/ :73-80,2016

Genomic profiling of lung adenocarcinoma patients reveals therapeutic targets and confers clinical benefit when standard molecular testing is negative
ONCOTARGET 7/17 :24,172-24,178,2016

A randomized phase II trial of ERCC1 and RRM1 mRNA expression-based chemotherapy versus docetaxel/carboplatin in advanced non-small cell lung cancer
CANCER CHEMOTHERAPY AND PHARMACOLOGY 77/3 :539-548,2016

An unusual cause of early aortic bioprosthetic valve failure.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING 17/4 :428-,2016

Clinical outcomes in ALK-rearranged lung adenocarcinomas according to ALK fusion variants.
JOURNAL OF TRANSLATIONAL MEDICINE 14/1 :296-,2016

Clinical course of stage IV invasive mucinous adenocarcinoma of the lung
LUNG CANCER 102/ :82-88,2016

The frequency and clinical impact of HER2 alterations in lung adenocarcinoma
PLOS ONE 12/2 :e0171280-,2017

Co-clinical trials demonstrate predictive biomarkers for dovitinib, an FGFR inhibitor, in lung squamous cell carcinoma.
ANNALS OF ONCOLOGY 28/6 :1,250-1,259,2017

Open-Label, Multicenter, Phase II Study of Ceritinib in Patients With Non-Small-Cell Lung Cancer Harboring ROS1 Rearrangement.
JOURNAL OF CLINICAL ONCOLOGY 35/23 :2,613-2,618,2017

Good Laboratory Standards for Clinical Next-Generation Sequencing Cancer Panel Tests
Journal of Pathology and Translational Medicine 51/3 :191-204,2017

Molecular Testing of Lung Cancers
Journal of Pathology and Translational Medicine 51/3 :242-254,2017

Validation of ALK/ROS1 Dual Break Apart FISH Probe probe in non-small-cell lung cancer
LUNG CANCER 111/ :79-83,2017

Detection of activating and acquired resistant mutation in plasma from EGFR-mutated NSCLC patients by peptide nucleic acid (PNA) clamping-assisted fluorescence melting curve analysis.
ONCOTARGET 8/39 :65,111-65,122,2017

PD-L1 expression and CD8+ tumor-infiltrating lymphocytes are associated with ALK rearrangement and clinicopathological features in inflammatory myofibroblastic tumors
ONCOTARGET 8/52 :89,465-89,474,2017

Concordance of programmed death-ligand 1 expression between primary and metastatic non-small cell lung cancer by immunohistochemistry and RNA in situ hybridization.
ONCOTARGET 8/50 :87,234-87,243,2017

Biology of invasive mucinous adenocarcinoma of the lung
Translational Lung Cancer Research 6/5 :508-512,2017

Malignant lymphoma arising in cardiac myxoma, presenting with peripheral arterial emboli
CARDIOVASCULAR PATHOLOGY 32/ :26-29,2018

Clinical characteristics of T790M-positive lung adenocarcinoma after resistance to epidermal growth factor receptor-tyrosine kinase inhibitors with an emphasis on brain metastasis and survival
LUNG CANCER 121/ :12-17,2018

Genetic and clinicopathologic characteristics of lung adenocarcinoma with tumor spread through air spaces
LUNG CANCER 123/ :121-126,2018

Establishment of a platform of non-small-cell lung cancer patient-derived xenografts with clinical and genomic annotation.
LUNG CANCER 124/ :168-178,2018

Enhancer Remodeling and MicroRNA Alterations Are Associated with Acquired Resistance to ALK Inhibitors.
CANCER RESEARCH 78/12 :3,350-3,362,2018

Clinicopathologic analysis of 10 cases of pulmonary colloid adenocarcinoma and prognostic implication of invasive micropapillary component
PATHOLOGY RESEARCH AND PRACTICE 214/12 :2,093-2,098,2018

Molecular Diagnostic Assays and Clinicopathologic Implications of MET Exon 14 Skipping Mutation in Non?small-cell Lung Cancer
CLINICAL LUNG CANCER 20/1 :e123-,2019

Indoor radon exposure increases tumor mutation burden in never-smoker patients with lung adenocarcinoma.
LUNG CANCER 131/ :139-146,2019

Targeted next-generation sequencing panel (TruSight Tumor 170) in diffuse glioma: a single institutional experience of 135 cases
JOURNAL OF NEURO-ONCOLOGY 142/3 :445-454,2019

Comprehensive analysis of the characteristics and treatment outcomes of patients with non-small cell lung cancer treated with anti-PD-1 therapy in real-world practice.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 145/6 :1,613-1,623,2019

Provisional Guideline Recommendation for EGFR Gene Mutation Testing in Liquid Samples of Lung Cancer Patients: A Proposal by the Korean Cardiopulmonary Pathology Study Group
Journal of Pathology and Translational Medicine 53/3 :153-158,2019

Effect of thymectomy in elderly patients with non-thymomatous generalized myasthenia gravis
JOURNAL OF NEUROLOGY 266/4 :960-968,2019

Highly Multiplexed Fluorescence in Situ Hybridization for in Situ Genomics
JOURNAL OF MOLECULAR DIAGNOSTICS 21/3 :390-407,2019

Hyperprogressive disease during PD-1/PD-L1 blockade in patients with non-small-cell lung cancer
ANNALS OF ONCOLOGY 30/7 :1,104-1,113,2019

Dynamic changes in PD-L1 expression and CD8+ T cell infiltration in non-small cell lung cancer following chemoradiation therapy.
LUNG CANCER 136/ :30-36,2019

Prognostic factors of acinar- or papillary-predominant adenocarcinoma of the lung
LUNG CANCER 137/ :129-135,2019

Mutant Thr95Ile Transthyretin-Related Cardiac Amyloidosis With Polyneuropathy
CIRCULATION JOURNAL 83/11 :2,328-2,328,2019

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