연세대학교 이과대학 생화학과 연세대학교 의과대학 의학과 연세대학교 의과대학원 의학석사 연세대학교 의학대학원 의학박사 케임브리지대학교 실험심리학 박사후연구원
경력
2003-2007 연세대학교 의과대학 세브란스정신건강병원 전공의 2007-2009 연세대학교 의과대학 세브란스정신건강병원 강사 및 노인정신과 전임의 2009-2010 연세대학교 의과대학 세브란스병원 임상조교수 2010-2016 연세대학교 의과대학 세브란스병원 조교수 2015-2018 케임브리지대학교 행동인지신경과학센터 객원연구원 2016-현재 연세대학교 의과대학 세브란스병원 부교수 [보직] 2009-2015 서대문구치매지원센터장 2019.03-현재 연세의생명연구원 연구지원부장
논문
2021 Translational cognitive neuroscience of dementia with touchscreen operant chambers GENES BRAIN AND BEHAVIOR
2020 Coexistence of perseveration and apathy in the TDP-43 Q331K knock-in mouse model of ALS-FTD TRANSLATIONAL PSYCHIATRY
2020 Plasma Clusterin as a Potential Link Between Diabetes and Alzheimer Disease JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
2020 Exposure of ultrafine particulate matter causes glutathione redox imbalance in the hippocampus: A neurometabolic susceptibility to Alzheimer's pathology SCIENCE OF THE TOTAL ENVIRONMENT
2019 Response by Jin et al to Letter Regarding Article, “Atrial Fibrillation Catheter Ablation Improves 1-Year Follow-Up Cognitive Function, Especially in Patients With Impaired Cognitive Function” CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
2019 Hyperpolarized [1-13C]lactate flux increased in the hippocampal region in diabetic mice MOLECULAR BRAIN
2019 Low-dose pioglitazone can ameliorate learning and memory impairment in a mouse model of dementia by increasing LRP1 expression in the hippocampus SCIENTIFIC REPORTS
2019 Atrial Fibrillation Catheter Ablation Improves 1-Year Follow-Up Cognitive Function, Especially in Patients With Impaired Cognitive Function CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
2019 Assessment of mGluR5 KO mice under conditions of low stress using a rodent touchscreen apparatus reveals impaired behavioural flexibility driven by perseverative responses Molecular Brain
2018 Hyperpolarized [1-13C] pyruvate MR spectroscopy detect altered glycolysis in the brain of a cognitively impaired mouse model fed high-fat diet MOLECULAR BRAIN
2018 Involvement of amygdala-prefrontal dysfunction in the influence of negative emotion on the resolution of cognitive conflict in patients with schizophrenia. BRAIN AND BEHAVIOR
2018 Assessment of Cognitive Impairment in a Mouse Model of High-Fat Diet-Induced Metabolic Stress with Touchscreen-Based Automated Battery System EXPERIMENTAL NEUROBIOLOGY
2018 Lipidomic alterations in lipoproteins of patients with mild cognitive impairment and Alzheimer's disease by asymmetrical flow field-flow fractionation and nanoflow ultrahigh performance liquid chromatography-tandem mass spectrometry. JOURNAL OF CHROMATOGRAPHY A
2018 Long-Term Culture of Organotypic Hippocampal Slice from Old 3xTg-AD Mouse: An ex vivo Model of Alzheimer’s Disease PSYCHIATRY INVESTIGATION
2018 Particulate matter increases beta-amyloid and activated glial cells in hippocampal tissues of transgenic Alzheimer's mouse: Involvement of PARP-1 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2018 TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD. NATURE NEUROSCIENCE
2017 Optimizing reproducibility of operant testing through reinforcer standardization: identification of key nutritional constituents determining reward strength in touchscreens MOLECULAR BRAIN
2017 Diagnostic Value of Time-Constrained Naming Test in Mild Cognitive Impairment DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
2017 Contribution of fronto-striatal regions to emotional valence and repetition under cognitive conflict BRAIN RESEARCH
2017 Suppression of AIMP1 protects cognition in Alzheimer's disease model mice 3xTg-AD NEUROREPORT
2017 Agmatine ameliorates type 2 diabetes induced-Alzheimer's disease-like alterations in high-fat diet-fed mice via reactivation of blunted insulin signalling NEUROPHARMACOLOGY
2016 The burden of HIV-associated neurocognitive disorder (HAND) in the Asia-Pacific region and recommendations for screening ASIAN JOURNAL OF PSYCHIATRY
2016 Adjunctive α-lipoic acid reduces weight gain compared with placebo at 12 weeks in schizophrenic patients treated with atypical antipsychotics: a double-blind randomized placebo-controlled study INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
2016 Cholinesterase Inhibitor Donepezil Increases Mitochondrial Biogenesis through AMP-Activated Protein Kinase in the Hippocampus NEUROPSYCHOBIOLOGY
2016 Calcium influx-mediated translocation of m-calpain induces Ku80 cleavage and enhances the Ku80-related DNA repair pathway ONCOTARGET
2016 Blunted response of hippocampal AMPK associated with reduced neurogenesis in older versus younger mice PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
2016 Hair sterol signatures coupled to multivariate data analysis reveal an increased 7β-hydroxycholesterol production in cognitive impairment JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
2016 Utility of the Montreal Cognitive Assessment (MoCA) and its subset in HIV-associated neurocognitive disorder (HAND) screening JOURNAL OF PSYCHOSOMATIC RESEARCH
2016 Agmatine Ameliorates High Glucose-Induced Neuronal Cell Senescence by Regulating the p21 and p53 Signaling EXPERIMENTAL NEUROBIOLOGY
2016 The relationship between self-referential processing-related brain activity and anhedonia in patients with schizophrenia PSYCHIATRY RESEARCH
2015 Requirement of AMPK activation for neuronal metabolic-enhancing effects of antidepressant paroxetine NEUROREPORT
2015 Technical and clinical aspects of cortisol as a biochemical marker of chronic stress BMB REPORTS
2015 Adiponectin receptor-mediated signaling ameliorates cerebral cell damage and regulates the neurogenesis of neural stem cells at high glucose concentrations: an in vivo and in vitro study CELL DEATH & DISEASE
2015 Impairment of insulin receptor substrate 1 signaling by insulin resistance inhibits neurite outgrowth and aggravates neuronal cell death NEUROSCIENCE
2015 Altered neural basis of the reality processing and its relation to cognitive insight in schizophrenia PLOS ONE
2015 The Role of Orexin in Post- Stroke; Emphasizing on Inflammation, Cognitive decline, Depression following Stroke. MOLECULAR BRAIN
2015 Effect of hypertension on the resting-state functional connectivity in patients with Alzheimer's disease (AD) ARCHIVES OF GERONTOLOGY AND GERIATRICS
2014 Metabolomic signatures in peripheral blood associated with Alzheimer's disease amyloid-β-induced neuroinflammation JOURNAL OF ALZHEIMERS DISEASE
2014 Phosphorylation of hypothalamic AMPK on serine(485/491) related to sustained weight loss by alpha-lipoic acid in mice treated with olanzapine. PSYCHOPHARMACOLOGY
2014 HIV-associated neurocognitive disorder in HIV-infected Koreans: The Korean NeuroAIDS Project HIV MEDICINE
2013 Organotypic hippocampal slice culture from the adult mouse brain: A versatile tool for translational neuropsychopharmacology PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
2013 A carbon nanotube metal semiconductor field effect transistor-based biosensor for detection of amyloid-beta in human serum BIOSENSORS & BIOELECTRONICS
2013 Effects of Color Temperature and Brightness on Electroencephalogram Alpha Activity in a Polychromatic Light-emitting Diode. CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
2013 Bright illumination reduces parietal EEG alpha activity during a sustained attention task BRAIN RESEARCH
2013 Illumination influences working memory: An EEG study NEUROSCIENCE
2013 Is the GABA System Related to the Social Competence Improvement Effect of Aripiprazole? An 18F-Fluoroflumazenil PET Study PSYCHIATRY INVESTIGATION
2012 뇌척수액과 말초혈액 내 알츠하이머병의 생화학적 생체표지자 Journal of Korean Geriatric Psychiatry (노인정신의학)
2012 혈관성 치매 Journal of Korean Geriatric Psychiatry (노인정신의학)
2012 조현병에서 긍정 정서가 인지적 갈등 해결에 미치는 영향과 사회적 무쾌감증과의 관계 Korean Journal of Schizophrenia Research (대한조현병학회지)
2012 AMPK γ2 subunit gene PRKAG2 polymorphism associated with cognitive impairment as well as diabetes in old age PSYCHONEUROENDOCRINOLOGY
2011 Screening and Treating Wernicke's Encephalopathy among Alcoholic Patients in a University Hospital Journal of the Korean Neuropsychiatric Association (신경정신의학)
2011 Emotional priming with facial exposures in euthymic patients with bipolar disorder JOURNAL OF NERVOUS AND MENTAL DISEASE
2011 Leukocyte mitochondrial DNA (mtDNA) content is associated with depression in old women ARCHIVES OF GERONTOLOGY AND GERIATRICS
2010 Deficits in eye gaze during negative social interactions in patients with schizophrenia JOURNAL OF NERVOUS AND MENTAL DISEASE
2010 Restoration of mammillothalamic functional connectivity through thiamine replacement therapy in Wernicke's encephalopathy NEUROSCIENCE LETTERS
2009 Reduced activation in the mirror neuron system during a virtual social cognition task in euthymic bipolar disorder PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
2009 Mammillothalamic functional connectivity and memory function in Wernicke's encephalopathy BRAIN
2009 Nonverbal social behaviors of patients with bipolar mania during interactions with virtual humans. JOURNAL OF NERVOUS AND MENTAL DISEASE
2008 Interactive effect of central obesity and hypertension on cognitive function in older out-patients with Type 2 diabetes DIABETIC MEDICINE
2008 A preliminary investigation of alpha-lipoic acid treatment of antipsychotic drug-induced weight gain in patients with schizophrenia JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
2006 몰입적 가상 환경에서 니코틴이 정신분열병 환자의 대인거리에 미치는 영향:예비연구 Korean Journal of Psychopharmacology (대한정신약물학회지)