김경환
#인지증#뇌혈관질환#뇌졸중
|
학력
연세대학교 의학과학사 (1987)
연세대학교 의학과 석사 (1990)
연세대학교 의학과 박사 (1997)
연세대학교 의학과 석사 (1990)
연세대학교 의학과 박사 (1997)
경력
대한 경도인지장애 설립위원장
연세대학교 세브란스 병원 인턴
연세대학교 세브란스 병원 신경과 레지던트
연세대학교 세브란스 병원 뇌졸중 전임의, 강사
연세대학교 세브란스 병원 부교수
현재 연세대학교 세브란스 병원 교수
1997-2001 Post-doc Fellow in Neurology, Neurosurgery and Neuroscience, US San Francisco, Stanford University U.S.A
2001 Vising Professor in Neurocritical care, Geneva University, Switzerland
2004-2005 Clinical Fellow in Stroke and Neurocritical care, University of Southern California, U.S.A
연세대학교 세브란스 병원 인턴
연세대학교 세브란스 병원 신경과 레지던트
연세대학교 세브란스 병원 뇌졸중 전임의, 강사
연세대학교 세브란스 병원 부교수
현재 연세대학교 세브란스 병원 교수
1997-2001 Post-doc Fellow in Neurology, Neurosurgery and Neuroscience, US San Francisco, Stanford University U.S.A
2001 Vising Professor in Neurocritical care, Geneva University, Switzerland
2004-2005 Clinical Fellow in Stroke and Neurocritical care, University of Southern California, U.S.A
논문
Early Decrease in DNA Repair Proteins, Ku70 and Ku86, and Subsequent DNA Fragmentation After Transient Focal Cerebral Ischemia in Mice
Stroke 32: 1401-1407, 2001
Oxidative Stress and Neuronal DNA Fragmentation Mediate Age-Dependent Vulnerability to the Mitochondrial Toxin, 3-Nitropropionic Acid, in the Mouse Striatum Neurobiology of Disease 8: 114-126, 2001
Manganese Superoxide Dismutase Deficiency Exacerbates Cerebral Infarction After Focal Cerebral Ischemia/Reperfusion in Mice
Stroke 33: 809-815, 2002
Involvement of Superoxide in Excitotoxicity and DNA Fragmentation in Striatal Vulnerability in Mice After Treatment With the Mitochondrial Toxin, 3-Nitropropionic Acid
Journal of Cerebral Blood Flow & Metabolism 22: 798-809, 2002
Neurodegeneration in Striatum Induced by the Mitochondrial Toxin 3-Nitropropionic Acid: Role of Matrix Metalloproteinase-9 in Early Blood-Brain Barrier Disruption?
The Journal of Neuroscience 232:8733-8742, 2003
Neuronal Death/Survival Signaling Pathways in Cerebral Ischemia
The Journal of the American Society for Experimental NeuroTherapeutics 1: 17-25, 2004
Metalloporphyrin-based superoxide dismutase mimic attenuates the nuclear translocation of apoptosis-indcing factor andthe subsequent DNA fragmentation after permanent focalcerebral ischemia in mice
Stroke 36:2712-2717, 2005
Induction of apoptosis signal-regulating kinase 1 and oxidative stress mediate age-dependent vulnerability to 3-nitropropionc acid in the mouse striatum
Neuroscience Letters 430: 142-146, 2008
Excitotoxicity is required for induction of oxidative stress and apoptosis in mouse striatum by the mitochondrial toxin, 3-nitropropionic acid.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 20/0 :119-129,2000
Involvement of oxidative stress and caspase-3 in cortical infarction after photothrombotic ischemia in mice.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 20/0 :1690-1701,2000
Arterial pulsatility as an index of cerebral microangiopathy in diabetes.
STROKE 31/0 :1111-1115,2000
The Cytosolic Antioxidant, Copper/Zinc-Superoxide Dismutase Attenuates Blood-Brain Barrier Disruption and Oxidative Cellular Injury After Photothrombotic Cortical Ischemia in Mice.
NEUROSCIENCE 105/4 :1007-1018,2001
Oxidative Stress and Neuronal DNA Fragmentation Mediate Age-Dependent Vulnerability to the Mitochondrial Toxin, 3-Nitropropionic Acid, in the Mouse Striatum.
NEUROBIOLOGY OF DISEASE 8/0 :114-126,2001
Neuronal expression of the DNA repair protein Ku 70 after ischemic preconditioning corresponds to tolerance to global cerebral ischemia.
STROKE 32/0 :2388-2393,2001
Early decrease in DNA repair proteins, Ku70 and Ku86, and subsequent DNA fragmentation after transient focal cerebral ischemia in mice
STROKE 32/6 :1401-1407,2001
Manganese Superoxide Dismutase Deficiency Exacerbates Cerebral Infarction After Focal Cerebral Ischemia/Reperfusion in Mice Implications for the Production and Role of Superoxide Radicals
STROKE 33/0 :809-815,2002
Involvement of superoxide in excitotoxicity & DNA fragmentation in straiatal vulnerability in mice after treatment with the mitochondrial toxin, 3-NP
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 22/0 :798-809,2002
Neurodegeneration in stratum induced by the mitochondrial toxin 3-NP: role of matrix metalloproteinase-9 in darly blood-brain barrier disruption?
JOURNAL OF NEUROSCIENCE 23/25 :8733-8742,2003
3-nitropropionic Acid 투여 후 마우스 선조체에서 Apurinic/Apyrimidinic Endonuclease의 발현과 신경세포고사
JOURNAL OF THE KOREAN NEUROLOGICAL ASSOCIATION 23/4 :510-518,2005
Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II
NATURE 435/435 :347-353,2005
Early nuclear translocation of endonuclease G and subsequent DNA fragmentation after transient focal cerebral ischemia in mice
NEUROSCIENCE LETTERS 386/ :23-27,2005
Metalloporphyrin-based superoxide dismutase mimic attenuates the nuclear translocation of apoptosis-inducing factor and the subsequent DNA fragmentation after permanent focal cerebral ischemia in mice
STROKE 36/ :2712-2717,2005
영구적 국소 대뇌 허혈 생쥐 모델에서 활성 산소종에 의한 세포고사 유도인자의 핵내 이동과 세포고사
대한뇌졸중학회지 7/2 :214-223,2005
생쥐 Pilocarpine 모델에서 중첩경련으로 유발한 해마신경세포 사멸과 이끼섬유발아에 대한 MMP-9의 역할
대한간질학회지(Journal of Korean Epilepsy Society) 9/2 :119-128,2005
Minocycline inhibits caspase-dependent and -independent cell death pathways and is neuroprotective against hippocampal damage after treatment with kainic acid in mice
NEUROSCIENCE LETTERS 398/ :195-200,2006
Kainic Acid 유발 마우스 간질모델에서 Minocycline에 의한 Caspase 의존성 세포고사 억제
대한간질학회지(Journal of Korean Epilepsy Society) 10/1 :3-10,2006
국소 대뇌 허혈 및 재관류 후 생쥐 모델에서 활성 산소 제거제(MnTBAP)에 의한 Endonuclease G의 조기 핵 내 이동방지 및 뇌경색 감소
대한신경과학회지(JournalOfTheKoreanNeurologicalAssociation) 25/4 :535-543,2007
Preconditioning with chronic cerebral hypoperfusion reduces a focal cerebral ischemic injury and increases apurinic/apyrimidinic endonuclease/redox factor-1 and matrix metalloproteinase-2 expression
CURRENT NEUROVASCULAR RESEARCH 4/2 :89-97,2007
Tracing of Noradrenergic Neuronal Circuitry and Functional Recovery after Permanent Focal Cerebral Ischemia in Mice
Journal of Neurocritical Care 1/ :31-42,2008
Induction of apoptosis signal-regulating kinase 1 and oxidative stress mediate age-dependent vulnerability to 3-nitropropionic acid in the mouse striatum
Neuroscience Letters 430/ :142-146,2008
후뇌동맥박리에 의한 후뇌동맥경색증 1예
Journal of Neurocritical Care 1/ :59-61,2008
급성기 허혈성 뇌졸중에서 혈소판과 백혈구의 상호작용
Journal of Neurocritical Care 1/ :43-49,2008
급성 허혈성 뇌졸중치료 패러다임의 전환
Journal of Neurocritical Care 1/ :1-11,2008
일과성 국소 대뇌 허혈 생쥐 모델에서 Apoptosis Signal-Regulating Kinase 1의 증가 및 Ask1 표적 siRNA 처치에 의한 대뇌 허혈 감소
Journal of Neurocritical Care 1/2 :143-149,2008
일과성 국소 대뇌 허혈 생쥐 모델에서 APE/Ref-1 융합 아데노바이러스 처치에 의한 APE/Ref-1의 과발현 및 신경세포고사 감소
Journal of Neurocritical Care 1/2 :150-156,2008
콜린분해효소 억제제의 사용 유무에 따른소혈관성 치매 환자의 임상 경과
대한신경과학회지(Journal Of The Korean Neurological Association) 26/3 :209-215,2008
The adenoviral vector-mediated increase in apurinic/apyrimidinic endonuclease inhibits the induction of neuronal cell death after transient ischemic stroke in mice
Brain Research 1274/ :1-10,2009
Post-ischemic administration of peptide with apurinic/apyrimidinic endonuclease activity inhibits induction of cell death after focal cerebral ischemia/reperfusion in mice
Neuroscience Letters 460/2 :166-169,2009
The role of MMP-9 in integrin-mediated hippocampal cell death after pilocarpine-induced status epilepticus
Neurobiology Of Disease 36/1 :169-180,2009
근거중심의학의 관점에서 급성 허혈성 뇌졸중에서의 혈전용해제 투여 지침에 대한 고찰
대한혈관신경의학회 1/1 :27-32,2009
Inhibition of apoptosis signal-regulating kinase 1 reduces endoplasmic reticulum stress and nuclear huntingtin fragments in a mouse model of Huntington disease
Neuroscience 163/4 :1128-1134,2009
Oxidative Stress-Induced Necrotic Cell Death via Mitochondira-Dependent Burst of Reactive Oxygen Species
Current Neurovascular Research 6/4 :213-222,2009
INDUCTION OF STRIATAL NEUROGENESIS ENHANCES FUNCTIONAL RECOVERY IN AN ADULT ANIMAL MODEL OF NEONATAL HYPOXIC-ISCHEMIC BRAIN INJURY
NEUROSCIENCE 169/1 :259-268,2010
The Korean Addenbrooke's Cognitive Examination revised for differential diagnosis of Alzheimer's disease and subcortical ischaemic vascular dementia
Journal of Neurology 257/ :P179-,2010
Decisive role of apurinic/apyrimidinic endonuclease/Ref-1 in initiation of cell death
Molecular And Cellular Neuroscience 45/3 :267-276,2010
알츠하이머성 치매와 혈관성 치매의 특징비교
Vascular Neurology 2/1 :18-25,2010
Current Strategies for the Treatment of Atherosclerotic Plaques
Vascular Neurology 2/1 :14-17,2010
Apoptosis signal-regulating kinase 1 (Ask1) targeted small interfering RNA on ischemic neuronal cell death
BRAIN RESEARCH 1412/0 :73-78,2011
뇌졸중 치료 패러다임의 현재와 미래
Vascular Neurology 3/1 :13-19,2011
Cerebroprotective effects of red ginseng extract pretreatment against ischemia-induced oxidative stress and apoptosis
INTERNATIONAL JOURNAL OF NEUROSCIENCE 123/4 :269-277,2013
Apoptosis signal-regulating kinase-1 aggravates ROS-mediated striatal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 441/2 :280-285,2013
The Therapeutic Potential of Apoptosis Signal-Regulating
Vascular Neurology 5/- :3-6,2013
Differential caspase activity in the cortex and striatum with chronic infusion of 3-nitropropionic acid
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 465/3 :631-637,2015
Statins promote long-term recovery after ischemic stroke by reconnecting noradrenergic neuronal circuitry
NEURAL PLASTICITY 2015/Arti :1-10,2015
Knockdown of apoptosis signal-regulating kinase 1 affects ischaemia-induced astrocyte activation and glial scar formation
EUROPEAN JOURNAL OF NEUROSCIENCE 43/7 :912-922,2016
Apoptosis signal-regulating kinase 1 mediates striatal degeneration via the regulation of C1q
SCIENTIFIC REPORTS 6/ :18840-,2016
Changes in Blood Factors and Ultrasound Findings in Mild Cognitive Impairment and Dementia
FRONTIERS IN AGING NEUROSCIENCE 9/21 :-,2017
Stroke 32: 1401-1407, 2001
Oxidative Stress and Neuronal DNA Fragmentation Mediate Age-Dependent Vulnerability to the Mitochondrial Toxin, 3-Nitropropionic Acid, in the Mouse Striatum Neurobiology of Disease 8: 114-126, 2001
Manganese Superoxide Dismutase Deficiency Exacerbates Cerebral Infarction After Focal Cerebral Ischemia/Reperfusion in Mice
Stroke 33: 809-815, 2002
Involvement of Superoxide in Excitotoxicity and DNA Fragmentation in Striatal Vulnerability in Mice After Treatment With the Mitochondrial Toxin, 3-Nitropropionic Acid
Journal of Cerebral Blood Flow & Metabolism 22: 798-809, 2002
Neurodegeneration in Striatum Induced by the Mitochondrial Toxin 3-Nitropropionic Acid: Role of Matrix Metalloproteinase-9 in Early Blood-Brain Barrier Disruption?
The Journal of Neuroscience 232:8733-8742, 2003
Neuronal Death/Survival Signaling Pathways in Cerebral Ischemia
The Journal of the American Society for Experimental NeuroTherapeutics 1: 17-25, 2004
Metalloporphyrin-based superoxide dismutase mimic attenuates the nuclear translocation of apoptosis-indcing factor andthe subsequent DNA fragmentation after permanent focalcerebral ischemia in mice
Stroke 36:2712-2717, 2005
Induction of apoptosis signal-regulating kinase 1 and oxidative stress mediate age-dependent vulnerability to 3-nitropropionc acid in the mouse striatum
Neuroscience Letters 430: 142-146, 2008
Excitotoxicity is required for induction of oxidative stress and apoptosis in mouse striatum by the mitochondrial toxin, 3-nitropropionic acid.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 20/0 :119-129,2000
Involvement of oxidative stress and caspase-3 in cortical infarction after photothrombotic ischemia in mice.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 20/0 :1690-1701,2000
Arterial pulsatility as an index of cerebral microangiopathy in diabetes.
STROKE 31/0 :1111-1115,2000
The Cytosolic Antioxidant, Copper/Zinc-Superoxide Dismutase Attenuates Blood-Brain Barrier Disruption and Oxidative Cellular Injury After Photothrombotic Cortical Ischemia in Mice.
NEUROSCIENCE 105/4 :1007-1018,2001
Oxidative Stress and Neuronal DNA Fragmentation Mediate Age-Dependent Vulnerability to the Mitochondrial Toxin, 3-Nitropropionic Acid, in the Mouse Striatum.
NEUROBIOLOGY OF DISEASE 8/0 :114-126,2001
Neuronal expression of the DNA repair protein Ku 70 after ischemic preconditioning corresponds to tolerance to global cerebral ischemia.
STROKE 32/0 :2388-2393,2001
Early decrease in DNA repair proteins, Ku70 and Ku86, and subsequent DNA fragmentation after transient focal cerebral ischemia in mice
STROKE 32/6 :1401-1407,2001
Manganese Superoxide Dismutase Deficiency Exacerbates Cerebral Infarction After Focal Cerebral Ischemia/Reperfusion in Mice Implications for the Production and Role of Superoxide Radicals
STROKE 33/0 :809-815,2002
Involvement of superoxide in excitotoxicity & DNA fragmentation in straiatal vulnerability in mice after treatment with the mitochondrial toxin, 3-NP
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 22/0 :798-809,2002
Neurodegeneration in stratum induced by the mitochondrial toxin 3-NP: role of matrix metalloproteinase-9 in darly blood-brain barrier disruption?
JOURNAL OF NEUROSCIENCE 23/25 :8733-8742,2003
3-nitropropionic Acid 투여 후 마우스 선조체에서 Apurinic/Apyrimidinic Endonuclease의 발현과 신경세포고사
JOURNAL OF THE KOREAN NEUROLOGICAL ASSOCIATION 23/4 :510-518,2005
Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II
NATURE 435/435 :347-353,2005
Early nuclear translocation of endonuclease G and subsequent DNA fragmentation after transient focal cerebral ischemia in mice
NEUROSCIENCE LETTERS 386/ :23-27,2005
Metalloporphyrin-based superoxide dismutase mimic attenuates the nuclear translocation of apoptosis-inducing factor and the subsequent DNA fragmentation after permanent focal cerebral ischemia in mice
STROKE 36/ :2712-2717,2005
영구적 국소 대뇌 허혈 생쥐 모델에서 활성 산소종에 의한 세포고사 유도인자의 핵내 이동과 세포고사
대한뇌졸중학회지 7/2 :214-223,2005
생쥐 Pilocarpine 모델에서 중첩경련으로 유발한 해마신경세포 사멸과 이끼섬유발아에 대한 MMP-9의 역할
대한간질학회지(Journal of Korean Epilepsy Society) 9/2 :119-128,2005
Minocycline inhibits caspase-dependent and -independent cell death pathways and is neuroprotective against hippocampal damage after treatment with kainic acid in mice
NEUROSCIENCE LETTERS 398/ :195-200,2006
Kainic Acid 유발 마우스 간질모델에서 Minocycline에 의한 Caspase 의존성 세포고사 억제
대한간질학회지(Journal of Korean Epilepsy Society) 10/1 :3-10,2006
국소 대뇌 허혈 및 재관류 후 생쥐 모델에서 활성 산소 제거제(MnTBAP)에 의한 Endonuclease G의 조기 핵 내 이동방지 및 뇌경색 감소
대한신경과학회지(JournalOfTheKoreanNeurologicalAssociation) 25/4 :535-543,2007
Preconditioning with chronic cerebral hypoperfusion reduces a focal cerebral ischemic injury and increases apurinic/apyrimidinic endonuclease/redox factor-1 and matrix metalloproteinase-2 expression
CURRENT NEUROVASCULAR RESEARCH 4/2 :89-97,2007
Tracing of Noradrenergic Neuronal Circuitry and Functional Recovery after Permanent Focal Cerebral Ischemia in Mice
Journal of Neurocritical Care 1/ :31-42,2008
Induction of apoptosis signal-regulating kinase 1 and oxidative stress mediate age-dependent vulnerability to 3-nitropropionic acid in the mouse striatum
Neuroscience Letters 430/ :142-146,2008
후뇌동맥박리에 의한 후뇌동맥경색증 1예
Journal of Neurocritical Care 1/ :59-61,2008
급성기 허혈성 뇌졸중에서 혈소판과 백혈구의 상호작용
Journal of Neurocritical Care 1/ :43-49,2008
급성 허혈성 뇌졸중치료 패러다임의 전환
Journal of Neurocritical Care 1/ :1-11,2008
일과성 국소 대뇌 허혈 생쥐 모델에서 Apoptosis Signal-Regulating Kinase 1의 증가 및 Ask1 표적 siRNA 처치에 의한 대뇌 허혈 감소
Journal of Neurocritical Care 1/2 :143-149,2008
일과성 국소 대뇌 허혈 생쥐 모델에서 APE/Ref-1 융합 아데노바이러스 처치에 의한 APE/Ref-1의 과발현 및 신경세포고사 감소
Journal of Neurocritical Care 1/2 :150-156,2008
콜린분해효소 억제제의 사용 유무에 따른소혈관성 치매 환자의 임상 경과
대한신경과학회지(Journal Of The Korean Neurological Association) 26/3 :209-215,2008
The adenoviral vector-mediated increase in apurinic/apyrimidinic endonuclease inhibits the induction of neuronal cell death after transient ischemic stroke in mice
Brain Research 1274/ :1-10,2009
Post-ischemic administration of peptide with apurinic/apyrimidinic endonuclease activity inhibits induction of cell death after focal cerebral ischemia/reperfusion in mice
Neuroscience Letters 460/2 :166-169,2009
The role of MMP-9 in integrin-mediated hippocampal cell death after pilocarpine-induced status epilepticus
Neurobiology Of Disease 36/1 :169-180,2009
근거중심의학의 관점에서 급성 허혈성 뇌졸중에서의 혈전용해제 투여 지침에 대한 고찰
대한혈관신경의학회 1/1 :27-32,2009
Inhibition of apoptosis signal-regulating kinase 1 reduces endoplasmic reticulum stress and nuclear huntingtin fragments in a mouse model of Huntington disease
Neuroscience 163/4 :1128-1134,2009
Oxidative Stress-Induced Necrotic Cell Death via Mitochondira-Dependent Burst of Reactive Oxygen Species
Current Neurovascular Research 6/4 :213-222,2009
INDUCTION OF STRIATAL NEUROGENESIS ENHANCES FUNCTIONAL RECOVERY IN AN ADULT ANIMAL MODEL OF NEONATAL HYPOXIC-ISCHEMIC BRAIN INJURY
NEUROSCIENCE 169/1 :259-268,2010
The Korean Addenbrooke's Cognitive Examination revised for differential diagnosis of Alzheimer's disease and subcortical ischaemic vascular dementia
Journal of Neurology 257/ :P179-,2010
Decisive role of apurinic/apyrimidinic endonuclease/Ref-1 in initiation of cell death
Molecular And Cellular Neuroscience 45/3 :267-276,2010
알츠하이머성 치매와 혈관성 치매의 특징비교
Vascular Neurology 2/1 :18-25,2010
Current Strategies for the Treatment of Atherosclerotic Plaques
Vascular Neurology 2/1 :14-17,2010
Apoptosis signal-regulating kinase 1 (Ask1) targeted small interfering RNA on ischemic neuronal cell death
BRAIN RESEARCH 1412/0 :73-78,2011
뇌졸중 치료 패러다임의 현재와 미래
Vascular Neurology 3/1 :13-19,2011
Cerebroprotective effects of red ginseng extract pretreatment against ischemia-induced oxidative stress and apoptosis
INTERNATIONAL JOURNAL OF NEUROSCIENCE 123/4 :269-277,2013
Apoptosis signal-regulating kinase-1 aggravates ROS-mediated striatal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 441/2 :280-285,2013
The Therapeutic Potential of Apoptosis Signal-Regulating
Vascular Neurology 5/- :3-6,2013
Differential caspase activity in the cortex and striatum with chronic infusion of 3-nitropropionic acid
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 465/3 :631-637,2015
Statins promote long-term recovery after ischemic stroke by reconnecting noradrenergic neuronal circuitry
NEURAL PLASTICITY 2015/Arti :1-10,2015
Knockdown of apoptosis signal-regulating kinase 1 affects ischaemia-induced astrocyte activation and glial scar formation
EUROPEAN JOURNAL OF NEUROSCIENCE 43/7 :912-922,2016
Apoptosis signal-regulating kinase 1 mediates striatal degeneration via the regulation of C1q
SCIENTIFIC REPORTS 6/ :18840-,2016
Changes in Blood Factors and Ultrasound Findings in Mild Cognitive Impairment and Dementia
FRONTIERS IN AGING NEUROSCIENCE 9/21 :-,2017
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