구본녀

  #간이식마취#뇌사마취관리#심장질환환자의 비심장수술 #집중관리#수술후 통증관리

학력

연세대학교 의과대학 의학과 학사(1995)
연세대학교 의과대학 의학과 석사(1999)
연세대학교 의과대학 의학과 박사(2002)

경력

1995 세브란스 병원 인턴 과정 수료
1996-1999 세브란스 병원 마취과 전공의 수료
2000-2002 세브란스 병원 마취과 연구 강사
2003-2005 세브란스 병원 마취통증의학교실 전임 강사 역임
2006-2009 세브란스 병원 마취통증의학교실 조교수
2010- 현재 세브란스 병원 마취통증의학교실 부교수 재직 중

논문

Effect of Ginseng Saponins on the Recombinant Serotonin Type 3A Receptor Expressed in Xenopus Oocytes: Implication of Possible Application as an Antie
The Journal of Alternative and complementary medicine 9/4 :505-510,2003

간이식 수술 환자에서 폐동맥 카테터 및 식도도플러로측정한 혈역학적 지표들의 비교
대한마취과학회지(Korean Journal Of Anesthesiology) 47/2 :211-215,2004

고농도 Sevoflurane을 이용한 폐활량 흡입마취유도시사전 산소 및 대기 호흡군 간의 호흡 양상의 차이
대한마취과학회지(Korean Journal Of Anesthesiology) 47/2 :167-173,2004

선천성 Long QT 증후군 환자의 마취관리
대한마취과학회지(Korean Journal Of Anesthesiology) 46/6 :743-746,2004

정맥마취제가 유전자 재조합 세로토닌 제3형 수용체에 미치는 작용
대한정맥마취학회지 8/4 :219-225,2004

Cavitron Ultrasonic Surgical Aspirator 로 간 절제 시경식도초음파를 이용한 공기색전증의 발생 빈도와 정도
대한마취과학회지(Korean Journal Of Anesthesiology) 47/1 :64-68,2004

Lidocaine을 혼합한 Bupivacaine의 고비중 척추마취시 회복시간
대한마취과학회지(Korean Journal Of Anesthesiology) 46/6 :679-683,2004

Nasotracheal intubation in an infant with Pierre Robin syndrome using two fibreoptic bronchoscopes of different diameter [3]
PEDIATRIC ANESTHESIA 14/ :366-367,2004

개구가 어려운 소아에서 성인 및 소아용 굴곡성 기관지경 두가지를 이용한 경비 기관내 삽관
대한마취과학회지(Korean Journal Of Anesthesiology) 43/6 :-,2004

Comparison of continuous epidural and intravenous analgesia for postoperative pain control in pediatric lower extremity surgery
YONSEI MEDICAL JOURNAL 45/5 :789-795,2004

기관내 삽관 후 발생한 종격동 기종
대한마취과학회지(Korean Journal Of Anesthesiology) 48/3 :320-323,2005

Sevoflurane의 폐활량 흡입마취유도 중 조절환기와자발호흡에서 나타나는 임상적 특징의 비교
대한마취과학회지(Korean Journal Of Anesthesiology) 48/3 :241-246,2005

The spatula introducer for insertion of the flexible reinforced laryngeal mask airway(RLMA)
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE 52/1 :117-118,2005

소아환자의 경막외 미추 차단에서 이상적인 바늘천자의 각도: 천추열공 부위의 초음파 영상을 통한 연구
소아마취(Korean J Ped Anesth) 9/1 :36-40,2005

The relationship of the anthropometric variables to the infusion rate of rocuronium in the elderly
YONSEI MEDICAL JOURNAL 46/5 :643-647,2005

회복실에서의 낮은 맥박 산소포화도의 발생빈도
대한마취과학회지(Korean Journal Of Anesthesiology) 49/3 :360-364,2005

복강경하 위절제술이 개복술과 비교하여 수술 후 배뇨기능에 미치는 효과
대한Endourology학회지 4/1 :-,2005

Hepatic resection by the Cavitron Ultrasonic Surgical Aspirator(R) increases the incidence and severity of venous air embolism
ANESTHESIA AND ANALGESIA 101/4 :966-970,2005

The effect of epidural sufentanil in ropivacaine on urinary retention in patients undergoing gastrectomy
BRITISH JOURNAL OF ANAESTHESIA 97/3 :414-418,2006

과열된 혈액의 수혈로 인한 급성 용혈
대한마취과학회지(Korean Journal Of Anesthesiology) 50/4 :463-465,2006

Determination of the optimal angle for needle insertion during caudal block in children using ultrasound imaging
ANAESTHESIA 61/ :946-949,2006

Argininosuccinic Acidemia 환아의 생체 부분 간이식의 마취 경험
대한마취과학회지(Korean Journal Of Anesthesiology) 49/4 :563-566,2006

복강경하 위절제술을 위한 전신-경막외 병용마취 시 sevoflurane 요구량 감소 효과
대한마취과학회지(Korean Journal Of Anesthesiology) 50/1 :42-47,2006

Charcot-Marie-Tooth씨병 산모의 척추-경막외 병용마취
대한마취과학회지(Korean Journal Of Anesthesiology) 50/1 :108-111,2006

Cardiac Arrest by Venous Air Embolism During Hepatic Resection Using the Cavitron Ultrasonic Surgical Aspirator
ANESTHESIA AND ANALGESIA 103/2 :493-494,2006

Respiratory depression caused by remifentanil infusion for postoperative pain control [69]
ANESTHESIA AND ANALGESIA 103/6 :1627-1628,2006

Preoperative greater occipital nerve block in total thyroidectomy patients can reduce postoperative occipital headache and posterior neck pain
THYROID 16/6 :599-603,2006

To make epidural catheterization less difficult in infants
PEDIATRIC ANESTHESIA 16/ :1196-1197,2006

The Analgesic Effect of Single Dose of Intrathecal Magnesium Sulfate
대한마취과학회지(Korean Journal Of Anesthesiology) 52/6 :72-76,2007

Prepuncture Ultrasound-Measured Distance: An Accurate Reflection of Epidural Depth in Infants and Small Children
REGIONAL ANESTHESIA AND PAIN MEDICINE 32/2 :102-106,2007

Neutralized rocuronium (pH 7.4) before administration prevents injection pain in awake patients: a randomized prospective trial
JOURNAL OF CLINICAL ANESTHESIA 19/6 :418-423,2007

Transient postoperative harlequin syndrome combined with Horner's syndrome in a pediatric patient after neck mass excision
PEDIATRIC ANESTHESIA 17/6 :597-598,2007

Laparoscopy-assisted subtotal gastrectomy under thoracic epidural-general anesthesia leading to the effects on postoperative micturition
Surgical Endoscopy 22/ :724-730,2008

Comparison of remifentanil and fentanyl for postoperative pain control after abdominal hysterectomy
Yonsei Medical Journal 49/ :204-210,2008

Anandamide inhibition of 5-HT3A receptors varies with receptor density and desensitization
Molecular Pharmacology 73/2 :314-322,2008

Amino acid residues involved in agonist binding and its linking to channel gating, proximal to transmembrane domain of 5-HT3A receptor for halothane modulation
Korean Journal Of Anesthesiology(대한마취과학회지) 56/1 :66-73,2009

Desflurane의 세로토닌3A형 수용체 항진작용에 대한 인삼사포닌의 효과
Korean Journal Of Anesthesiology(대한마취과학회지) 56/6 :681-686,2009

The effect of pneumoperitoneum in the steep Trendelenburg position on cerebral oxygenation
Acta Anaesthesiologica Scandinavica 53/7 :895-899,2009

The effect of flexion on the level of termination of the dural sac in paediatric patients
Anaesthesia 64/10 :1072-1076,2009

The role of residues in binding loop A in desflurane and propofol modulation of recombinant 5-HT3A receptor
Neuroscience Letters 465/2 :147-150,2009

Ultrasound Evaluation of the Sacral Area and Comparison of Sacral Interspinous and Hiatal Approach for Caudal Block in Children
Anesthesiology 111/ :1135-1140,2009

Comparison of intrathecal fentanyl and sufentanil in low-dose dilute bupivacaine spinal anaesthesia for transurethral prostatectomy.
British Journal Of Anaesthesia 103/5 :750-754,2009

The relative position of ilioinguinal and iliohypogastric nerves in different age groups of pediatric patients
Acta Anaesthesiologica Scandinavica 54/ :566-570,2010

Spread of ropivacaine by a weight-based formula in a pediatric caudal block: a fluoroscopic examination
Acta Anaesthesiologica Scandinavica 54/ :562-565,2010

Effect of head rotation on overlap and relative position of internal jugular vein to carotid artery in infants and children: A study of the anatomy using ultrasonography
Journal Of Critical Care 25/2 :360e9-360e13,2010

Fentanyl-sparing effect of acetaminophen as a mixture of fentanyl in intravenous parent-/nurse-controlled analgesia after pediatric ureteroneocystostomy
Anesthesiology 113/3 :672-677,2010

Delayed detection of subcutaneous emphysema following routine endotracheal intubation -A case report-
Korean Journal Of Anesthesiology(대한마취과학회지) 59/3 :220-223,2010

Multiple cerebral infarction and paradoxical air embolism during hepatectomy using the Cavitron Ultrasonic Surgical Aspirator -A case report-
Korean Journal of Anesthesiology 59/ :133-136,2010

Differential effects of lidocaine and remifentanil on response to the tracheal tube during emergence from general anaesthesia
BRITISH JOURNAL OF ANAESTHESIA 106/3 :410-415,2011

Ramosetron for the prevention of postoperative nausea and vomiting (PONV): a meta-analysis
Korean Journal of Anesthesiology 61/5 :405-412,2011

Psychotropic and nonpsychotropic cannabis derivatives inhibit human 5-HT(3A) receptors through a receptor desensitization-dependent mechanism
NEUROSCIENCE 184/ :28-37,2011

The neuroprotective effect of agmatine after focal cerebral ischemia in diabetic rats.
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY 24/1 :39-50,2012

Ultrasonography reveals a high prevalence of lower spinal dysraphism in children with urogenital anomalies
ACTA ANAESTHESIOLOGICA SCANDINAVICA 56/5 :624-628,2012

Effect of sevoflurane on grafted kidney function in renal transplantation
Korean Journal of Anesthesiology 62/6 :529-535,2012

A pharmacodynamic analysis of factors affecting recovery from anesthesia with propofol-remifentanil target controlled infusion.
ACTA PHARMACOLOGICA SINICA 33/8 :1080-1084,2012

Combined treatment of 3-hydroxyflavone and imatinib mesylate increases apoptotic cell death of imatinib mesylate-resistant leukemia cells
LEUKEMIA RESEARCH 36/9 :1157-1164,2012

Agmatine promotes the migration of murine brain endothelial cells via multiple signaling pathways
LIFE SCIENCES 92/1 :42-50,2013

Comparison of emergence time in children undergoing minor surgery according to anesthetic: Desflurane and sevoflurane
YONSEI MEDICAL JOURNAL 54/3 :732-738,2013

Preconditioning effects of the anesthetic administered to the donor on grafted kidney function in living donor kidney transplantation recipients
MINERVA ANESTESIOLOGICA 79/5 :504-514,2013

Efficacy of intraoperative dexmedetomidine infusion on emergence agitation and quality of recovery after nasal surgery
BRITISH JOURNAL OF ANAESTHESIA 111/2 :222-228,2013

Synergistic activation of lipopolysaccharide-stimulated glial cells by propofol
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 438/2 :420-426,2013

Perioperative respiratory adverse events in children with active upper respiratory tract infection who received general anesthesia through an orotracheal tube and inhalation agents
Korean Journal of Anesthesiology 65/2 :136-141,2013

Effect of Propofol Post-treatment on Blood-Brain Barrier Integrity and Cerebral Edema After Transient Cerebral Ischemia in Rats.
NEUROCHEMICAL RESEARCH 38/11 :2276-2286,2013

Efficacy of Intrathecal Morphine Combined with Intravenous Analgesia versus Thoracic Epidural Analgesia after Gastrectomy
YONSEI MEDICAL JOURNAL 55/4 :1106-1114,2014

Low-dose dexmedetomidine reduces emergence agitation after desflurane anaesthesia in children undergoing strabismus surgery
YONSEI MEDICAL JOURNAL 55/2 :508-516,2014

Analgesic efficacy of caudal dexamethasone combined with ropivacaine in children undergoing orchiopexy
BRITISH JOURNAL OF ANAESTHESIA 112/5 :885-891,2014

Comparison of three sedation regimens for drug-induced sleep endoscopy
SLEEP AND BREATHING 19/2 :711-717,2015

Repeated Neonatal Propofol Administration Induces Sex-Dependent Long-Term Impairments on Spatial and Recognition Memory in Rats
BIOMOLECULES & THERAPEUTICS Continues: Journal of applied pharmacology ISSN 1225-6110 23/3 :251-260,2015

Risk Assessment of Mortality Following Intraoperative Cardiac Arrest Using POSSUM and P-POSSUM in Adults Undergoing Non-Cardiac Surgery
YONSEI MEDICAL JOURNAL 56/5 :1401-1407,2015

Intranuclear interactomic inhibition of NF-κB suppresses LPS-induced severe sepsis
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 464/3 :711-717,2015

Pharmacodynamic Estimate of Propofol-Induced Sedation and Airway Obstruction Effects in Obstructive Sleep Apnea-Hypopnea Syndrome
YONSEI MEDICAL JOURNAL 56/5 :1408-1414,2015

Clinical efficacy of the classic laryngeal mask airway in elderly patients: a comparison with young adult patients
Korean Journal of Anesthesiology 68/6 :568-574,2015

Propofol treatment modulates neurite extension regulated by immunologically challenged rat primary astrocytes: a possible role of PAI-1
ARCHIVES OF PHARMACAL RESEARCH 38/4 :556-565,2015

Effect of isoflurane post-treatment on tPA-exaggerated brain injury in a rat ischemic stroke model
Korean Journal of Anesthesiology 68/3 :281-286,2015

The effects of single-dose dexamethasone on inflammatory response and pain after uterine artery embolisation for symptomatic fibroids or adenomyosis: A randomised controlled study
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY 123/4 :580-587,2016

Effects of Postoperative Pain Management on Immune Function After Laparoscopic Resection of Colorectal Cancer:A Randomized Study
MEDICINE 95/24 :e3602-,2016

Efficacy of Intravenous Lidocaine During Endoscopic Submucosal Dissection for Gastric Neoplasm A Randomized, Double-Blind, Controlled Study
MEDICINE 95/18 :e3593-,2016

Betahistine reduces postoperative nausea and vomiting after laparoscopic gynecological surgery
MINERVA ANESTESIOLOGICA 82/6 :649-656,2016

Impact of Diabetes Mellitus on Radial and Ulnar Arterial Vasoreactivity after Radial artery cannulation: A randomized controlled trial
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 13/9 :701-707,2016

The Anti-inflammatory Effects of Agmatine on Transient Focal Cerebral Ischemia in Diabetic Rats
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY 28/3 :203-213,2016

Blockade of Apoptosis Signal-Regulating Kinase 1 Attenuates Matrix Metalloproteinase 9 Activity in Brain Endothelial Cells and the Subsequent Apoptosis in Neurons after Ischemic Injury
FRONTIERS IN CELLULAR NEUROSCIENCE 10/Articl :1-12,2016

Combined Subpectoral Implantation of Implantable Cardioverter-Defibrillator and Augmentation Mammoplasty in a Young Female Patient
KOREAN CIRCULATION JOURNAL 46/5 :734-738,2016

Intranasal Administration of Interleukin-1 Receptor Antagonist in a Transient Focal Cerebral Ischemia Rat Model
BIOMOLECULES & THERAPEUTICS 25/2 :149-157,2017

Isoflurane Postconditioning Inhibits tPA-Induced Matrix Metalloproteinases Activation After Hypoxic Injury via Low-Density Lipoprotein Receptor-Related Protein and Extracellular Signal-Regulated Kinase Pathway
NEUROCHEMICAL RESEARCH 42/5 :1,533-1,542,2017

Effect of caudal block using different volumes of local anaesthetic on optic nerve sheath diameter in children: a prospective, randomized trial
BRITISH JOURNAL OF ANAESTHESIA 118/5 :781-787,2017

Isoflurane preconditioning inhibits the effects of tissue-type plasminogen activator on brain endothelial cell in an in vitro model of ischemic stroke
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 14/5 :425-433,2017

Influence of caudal block on postoperative oliguria in infants undergoing bilateral ureteroneocystostomy: a retrospective analysis
PEDIATRIC ANESTHESIA 27/7 :695-701,2017

The Effects of Perioperative Anesthesia and Analgesia on Immune Function in Patients Undergoing Breast Cancer Resection: A Prospective Randomized Study
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 14/10 :970-976,2017

Regulation of Microglia and Macrophage Polarization via Apoptosis Signal-Regulating Kinase 1 Silencing after Ischemic/Hypoxic Injury
FRONTIERS IN MOLECULAR NEUROSCIENCE 10/ :261-274,2017

Cell-penetrating interactomic inhibition of nuclear factor-kappa B in a mouse model of postoperative cognitive dysfunction
SCIENTIFIC REPORTS 7/1 :113,482-113,498,2017

Erythropoietin Attenuates Postoperative Cognitive Dysfunction by Shifting Macrophage Activation toward the M2 Phenotype
FRONTIERS IN PHARMACOLOGY 8/839 :1-15,2017

Ultrasonographic optic nerve sheath diameter for predicting elevated intracranial pressure during laparoscopic surgery: a systematic review and meta-analysis
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 32/1 :175-182,2018

Effects of Tranexamic Acid Based on its Population Pharmacokinetics in Pediatric Patients Undergoing Distraction Osteogenesis for Craniosynostosis: Rotational Thromboelastometry (ROTEMTM) Analysis
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 15/8 :788-795,2018

Cell Type-Specific Mechanisms in the Pathogenesis of Ischemic Stroke: The Role of Apoptosis Signal-Regulating Kinase 1
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2018/ :1-9,2018

Comparison of Perioperative Renal Function Between Epidural and Intravenous Patient-Controlled Analgesia After Living-Donor Hepatectomy: A Retrospective Study
TRANSPLANTATION PROCEEDINGS 50/5 :1,365-1,371,2018

Effect of goal-directed haemodynamic therapy in free flap reconstruction for head and neck cancer
ACTA ANAESTHESIOLOGICA SCANDINAVICA 62/7 :903-914,2018

Apoptosis Signal-regulating Kinase 1 Silencing on Astroglial Inflammasomes in an Experimental Model of Ischemic Stroke
NEUROSCIENCE 390/ :218-230,2018

Intranuclear delivery of synthetic nuclear factor-kappa B p65 reduces inflammasomes after surgery
BIOCHEMICAL PHARMACOLOGY 158/ :141-152,2018

The Impact of Perioperative Factors on Changes in Diastolic Function after Kidney Transplantation: A Retrospective Analysis
YONSEI MEDICAL JOURNAL 60/3 :291-297,2019

Accuracy and Efficacy of Impedance Cardiography as a Non-Invasive Cardiac Function Monitor
YONSEI MEDICAL JOURNAL 60/8 :735-741,2019

Comparison between use of single lightwand and video laryngoscope-guided lightwand for tracheal intubation in simulated cervical spine-immobilized patients: a single-blind randomized study
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 47/11 :5,632-5,642,2019

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