강석구

  #뇌종양외과#두부외상

학력

1995 가톨릭대학교 의과대학 의학과 (학사)
1999 가톨릭대학교 의과대학 대학원 (의학석사)
2005 가톨릭대학교 의과대학 대학원 (의학박사)

경력

2003~2005 삼성서울병원 신경외과 임상강사
2005~2009 가톨릭대학교 의과대학 의정부성모병원 신경외과 조교수/부교수
2007~2009 미국 M.D. Anderson Cancer Center Post-Doc
2010~2012 가톨릭대학교 의과대학 서울성모병원 신경외과 부교수
2012~2016 연세대학교 의과대학 세브란스병원 신경외과 임상부교수
2016~2018 연세대학교 의과대학 세브란스병원 신경외과 임상교수
2018~ 연세대학교 의과대학 세브란스병원 신경외과 교수

논문

Staged Decompression of Chiari I Malformation Associated with Basilar Invagination. Kang SG, Jeun SS, Lee IW, Park CK, Hong YK, Kim MC, Kang JK: J Korean Neurosurg Soc 1998:27(10):1429-1433

Influence of Brain edema on the Antiischemic Effect of D-CPPene in Rat Focal Cerebral Infarction. Kang SG, Park CK, Kang JK: J Korean Neurosurg Soc 1999:28(8):1075-1081

Effect of Brain Oedema in the Measurement of Ischaemic Brain Damage in Focal Cerebral Infarction. Park CK, Kang SG. Acta Neurochir Suppl. 2000;76:269-271.

Lymphokine Activated Killer Cells from Umbilical Cord Blood Show Higher Antitumor Effect against Anaplastic Astrocytoma Cell Line (U87) and Medulloblastoma Cell Line (TE671) than Lymphokine Activated Killer Cells from Peripheral Blood. Kang SG, Ryu CH, Jeun SS, Park CK, Shin HJ, Kim JH, Kim MC, Kang JK. Childs Nerv Syst. 2004;20(3):154-162.

Surgical Approaches of Lateral Ventricle Tumors. Kang SG, Park K: J Korean Brain Tumor Soc 2004:3(2):82-87

Clinical and Radiological Prognostic Factors of Anaplastic Oligodendroglioma Treated by Combined Therapy. Neurol Med Chir (Tokyo). 2005 45(5):232-238; discussion 238-239.

Cytotoxicity of rat marrow stromal cells against malignant glioma cells. Childs Nerv Syst. 2005 21(7):528-538.

Interpretation of Wada Test in Anterior Temporal Lobectomy. J of The Kor Soc of Ster and Func Neurosur 2005:1(1):20-24

Combination celecoxib and temozolomide in C6 rat glioma orthotopic model. Oncol Rep. 2006 Jan;15(1):7-13.

Coexisting intracranial meningeal melanocytoma, dermoid tumor, and Dandy-Walker cyst in a patient with neurocutaneous melanosis. J Neurosurg. 2006 104(3):444-447.

Merlin inhibits growth hormone-regulated Raf-ERKs pathways by binding to Grb2 protein. Biochem Biophys Res Commun. 2006 24;340(4):1151-1157.

Effects of Hydroxycholroquine Co-administrated with Chemotherapeutic Agents on Malignant Glioma Cell Lines: in vitro Study. J Korean Neurosurg Soc. 2006 39(4):317-317 letter to editor
Multiple stem cell traits of expanded rat bone marrow stromal cells. Exp Neurol. 2006 199(2):416-26.

Diagnostic method for differentiating external hydrocephalus from simple subdural hygroma. J Neurosurg. 2006 105(1):65-70.

Combined direct anastomosis and encephaloduroarteriogaleosynangiosis using inverted superficial temporal artery-galeal flap and superficial temporal artery-galeal pedicle in adult moyamoya disease Surg Neurol. 2006 66(4):389-394; discussion 395.

Clinical images: Myositis ossificans of the upper extremity. Arthritis Rheum. 2007 56(7):2454.

Tethered cord syndrome; Surgical indication, technique and outcome. J Korean Neurosurg Soc. 2007 42(2):77-82.

Sudden cortical blindness in an adult with moyamoya disease. Surg Neurol. 2007 67(3):303-307.

Simple excision and periosteal reattachment for the treatment of calcified cephalhematoma - Technical note. J Neurosurg. 2007 106(2 Suppl):162-4.

Pituitary abscess in a pregnant woman. J Clin Neurosci. 2007 14(11):1135-1139.

Provisional experiences about KSPNO-G051, KSPNO-G052 protocols for the treatment of central nervous system germ cell tumors. J Korean Soc Pediatric Neurosurg 2007 4(1):57-66

Surgical results in pediatric moyamoya disease: Angiographic revascularization and the clinical results. Clin Neurol Neurosurg. 2007 109(2):125-31.

Clinical and radiographie results of unilateral transpedicular balloon kyphoplasty for the treatment of osteoporotic vertebral compression fractures. Acta Neurochir Suppl. 2008;101:157-60.

Cranioplasty effect on the cerebral hemodynamics and cardiac function. Acta Neurochir Suppl. 2008;102:15-20.

Cytotoxicity of human umbilical cord blood-derived mesenchymal stem cells against human malignant glioma cells. Childs Nerv Syst. 2008 24(3):293-302.

Comparison of the effect of decompressive craniectomy on different neurosurgical diseases. Acta Neurochir (Wien). 2009 151(1):21-30.

Risk Factors and Surgical Treatment for Symptomatic Adjacent S
C-Jun N-terminal kinase has a pivotal role in the maintenance of self-renewal and tumorigenicity in glioma stem-like cells
ONCOGENE 31/44 :4655-4666,2012

Isolation of glioma cancer stem cells in relation to histological grades in glioma specimens.
CHILDS NERVOUS SYSTEM 29/2 :217-229,2013

Postoperative nasal symptoms associated with an endoscopic endonasal transsphenoidal approach
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY 270/4 :1355-1359,2013

Changes in the biological characteristics of glioma cancer stem cells after serial in vivo subtransplantation.
CHILDS NERVOUS SYSTEM 29/1 :55-64,2013

Existence of glioma stroma mesenchymal stemlike cells in Korean glioma specimens
CHILDS NERVOUS SYSTEM 29/4 :549-563,2013

Increased in vivo angiogenic effect of glioma stromal mesenchymal stem-like cells on glioma cancer stem cells from patients with glioblastoma
INTERNATIONAL JOURNAL OF ONCOLOGY 42/5 :1754-1762,2013

A novel 2-pyrone derivative, BHP, impedes oncogenic KRAS-driven malignant progression in breast cancer
CANCER LETTERS 337/1 :49-57,2013

Isolation of mesenchymal stem-like cells in meningioma specimens
INTERNATIONAL JOURNAL OF ONCOLOGY 43/4 :1260-1268,2013

Bilateral Nasoseptal Flaps for Endoscopic Endonasal Transsphenoidal Approach
JOURNAL OF CRANIOFACIAL SURGERY 24/ :1569-1572,2013

Fractionated radiation-induced nitric oxide promotes expansion of glioma stem-like cells
CANCER SCIENCE 104/ :1172-1177,2013

Isolation of tumor spheres and mesenchymal stem-like cells from a single primitive neuroectodermal tumor specimen
CHILDS NERVOUS SYSTEM 29/12 :2229-2239,2013

Bilateral modified nasoseptal "rescue" flaps in the endoscopic endonasal transsphenoidal approach
LARYNGOSCOPE 123/11 :2605-2609,2013

Isolation of Mesenchymal Stem-like Cells from a Pituitary Adenoma Specimen
대한의생명과학회지 19/4 :295-302,2013

Temozolomide salvage chemotherapy for recurrent anaplastic oligodendroglioma and oligo-astrocytoma
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY 54/6 :489-495,2013

Study of freshly excised brain tissues using terahertz imaging
BIOMEDICAL OPTICS EXPRESS 5/8 :2837-2842,2014

Role of the superior turbinate when performing endoscopic endonasal transsphenoidal approach
FOLIA MORPHOLOGICA 73/1 :73-78,2014

Prognostic value of glioma cancer stem cell isolation in survival of primary glioblastoma patients
STEM CELLS INTERNATIONAL 2014/0 :0-0,2014

Atypical location and clinical behavior of a subset of intracranial germ cell tumors in children younger than 3 years of age
JOURNAL OF NEUROSURGERY-PEDIATRICS 14/4 :348-355,2014

Potential use of glioblastoma tumorsphere: Clinical credentialing
ARCHIVES OF PHARMACAL RESEARCH 38/3 :402-407,2015

T2 - and T*2-weighted MRI of rat glioma using polysorbate-coated magnetic nanocrystals as a blood-pool contrast agent
RSC ADVANCES 5/25 :19708-19714,2015

Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy
NATURE MEDICINE 21/4 :395-400,2015

Primary diffuse leptomeningeal gliosarcoma
Brain Tumor Reserach and Treatment 3/1 :34-38,2015

The Added Prognostic Value of Preoperative Dynamic Contrast-Enhanced MRI Histogram Analysis in Patients with Glioblastoma: Analysis of Overall and Progression-Free Survival
AMERICAN JOURNAL OF NEURORADIOLOGY 36/12 :2235-2241,2015

Mesenchymal Stem Cells Isolated From Human Gliomas Increase Proliferation and Maintain Stemness of Glioma Stem Cells Through the IL-6/gp130/STAT3 Pathway
STEM CELLS 33/8 :2400-2415,2015

Pseudoprogression in glioblastoma patients: the impact of extent of resection
JOURNAL OF NEURO-ONCOLOGY 126/3 :559-566,2016

Tumor mesenchymal stem-like cell as a prognostic marker in primary glioblastoma
STEM CELLS INTERNATIONAL 2016/Arti :1-7,2016

PKCδ activated by c-MET enhances infiltration of human glioblastoma cells through NOTCH2 signaling
ONCOTARGET 7/4 :4890-4902,2016

Strategies of mesenchymal invasion of patient-derived brain tumors: Microenvironmental adaptation.
SCIENTIFIC REPORTS 25/6 :24912-24912,2016

Current and future perspectives in craniosynostosis.
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY 59/3 :247-249,2016

Failure of a patient-derived xenograft for brain tumor model prepared by implantation of tissue fragments
CANCER CELL INTERNATIONAL 16/43 :1-6,2016

Isolation and characterization of tumorspheres from a recurrent pineoblastoma patient: Feasibility of a patient-derived xenograft.
INTERNATIONAL JOURNAL OF ONCOLOGY 49/ :567-578,2016

Histopathological implications of ventricle wall 5-aminolevulinic acid-induced fluorescence in the absence of tumor involvement on magnetic resonance images
ONCOLOGY REPORTS 36/2 :837-844,2016

A polyethylene glycol-based hydrogel as macroporous scaffold for tumorsphere formation of glioblastoma multiforme
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY 39/ :10-15,2016

Incremental Prognostic Value of ADC Histogram Analysis over MGMT Promoter Methylation Status in Patients with Glioblastoma
RADIOLOGY 281/1 :175-184,2016

Inhibiting stemness and invasive properties of glioblastoma tumorsphere by combined treatment with temozolomide and a newly designed biguanide (HL156A)
ONCOTARGET 7/40 :65,643-65,659,2016

Terahertz reflectometry imaging for low and high grade gliomas
SCIENTIFIC REPORTS 6/36,040 :1-9,2016

Success of tumorsphere isolation from WHO grade IV gliomas does not correlate with the weight of fresh tumor specimens: an immunohistochemical characterization of tumorsphere differentiation
CANCER CELL INTERNATIONAL 16/75 :1-7,2016

Hemangiopericytomas in the Central Nervous System: A Multicenter Study of Korean Cases with Validation of the Usage of STAT6 Immunohistochemistry for Diagnosis of Disease
ANNALS OF SURGICAL ONCOLOGY 23/ :S954-S961,2016

Tumor-associated mesenchymal stem-like cells provide extracellular signaling cue for invasiveness of glioblastoma cells
ONCOTARGET 8/1 :1,438-1,448,2017

Concurrent Chemoradiotherapy with Temozolomide Followed by Adjuvant Temozolomide for Newly Diagnosed Glioblastoma Patients: A Retrospective Multicenter Observation Study in Korea
CANCER RESEARCH AND TREATMENT 49/1 :193-203,2017

Inhibition of glioblastoma tumorspheres by combined treatment with 2-deoxyglucose and metformin
NEURO-ONCOLOGY 19/2 :197-207,2017

Primary central nervous system lymphoma and atypical glioblastoma: differentiation using the initial area under the curve derived from dynamic contrast-enhanced MR and the apparent diffusion coefficient
EUROPEAN RADIOLOGY 27/4 :1,344-1,351,2017

Amide proton transfer imaging to discriminate between low- and high-grade gliomas: added value to apparent diffusion coefficient and relative cerebral blood volume
EUROPEAN RADIOLOGY 27/8 :3,181-3,189,2017

Spontaneous Acute Subdural Hemorrhage in a Patient with a Tick Borne Bunyavirus-Induced Severe Fever with Thrombocytopenia Syndrome
Korean Journal of neurotrauma 13/1 :57-60,2017

Effects of Postoperative Radiotherapy on Leptomeningeal Carcinomatosis or Dural Metastasis after Resection of Brain Metastases in Breast Cancer Patients
CANCER RESEARCH AND TREATMENT 49/3 :748-758,2017

The initial area under the curve derived from dynamic contrast-enhanced MRI improves prognosis prediction in glioblastoma with unmethylated MGMT promoter
AMERICAN JOURNAL OF NEURORADIOLOGY 38/8 :1,528-1,535,2017

Effectiveness of navigation-guided cyst aspiration before resection of large cystic brain tumors: a proof of concept for more radical surgery
ACTA NEUROCHIRURGICA 159/10 :1,947-1,954,2017

Elderly patients with newly diagnosed glioblastoma: can preoperative imaging descriptors improve the predictive power of a survival model?
JOURNAL OF NEURO-ONCOLOGY 134/2 :423-431,2017

Long-term outcomes of concomitant chemoradiotherapy with temozolomide for newly diagnosed glioblastoma patients A single-center analysis
MEDICINE 96/27 :e7422-,2017

Regulation of cAMP and GSK3 signaling pathways contributes to the neuronal conversion of glioma
PLOS ONE 12/11 :e0178881-,2017

Amide proton transfer imaging for differentiation of benign and atypical meningiomas
EUROPEAN RADIOLOGY 28/1 :331-339,2018

Prediction of IDH1-Mutation and 1p/19q-Codeletion Status Using Preoperative MR Imaging Phenotypes in Lower Grade Gliomas
AMERICAN JOURNAL OF NEURORADIOLOGY 39/1 :37-42,2018

The mode and dynamics of glioblastoma cell invasion into a decellularized tissue-derived extracellular matrix-based three-dimensional tumor model
SCIENTIFIC REPORTS 8/1 :4608-1-4608-12,2018

Synthesis and structure-activity relationships of quinolinone and quinoline-based P2X7 receptor antagonists and their anti-sphere formation activities in glioblastoma cells
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 151/ :462-481,2018

Whole-Tumor Histogram and Texture Analyses of DTI for Evaluation of IDH1-Mutation and 1p/19q-Codeletion Status in World Health Organization Grade II Gliomas
AMERICAN JOURNAL OF NEURORADIOLOGY 39/4 :693-698,2018

Force-mediated proinvasive matrix remodeling driven by tumor-associated mesenchymal stem-like cells in glioblastoma
BMB REPORTS 51/4 :182-187,2018

Regulation of bioenergetics through dual inhibition of aldehyde dehydrogenase and mitochondrial complex I suppresses glioblastoma tumorspheres
NEURO-ONCOLOGY 20/7 :954-965,2018

Proinvasive extracellular matrix remodeling in tumor microenvironment in response to radiation
ONCOGENE 37/24 :3,317-3,328,2018

Human glioblastoma arises from subventricular zone cells with low-level driver mutations.
NATURE 560/ :243-247,2018

Primary central nervous system lymphoma and atypical glioblastoma: Differentiation using radiomics approach
EUROPEAN RADIOLOGY 28/9 :3,832-3,839,2018

Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness
EXPERIMENTAL AND MOLECULAR MEDICINE 50/ :137-149,2018

Pheochromocytoma with Brain Metastasis: A Extremely Rare Case in Worldwide
Brain Tumor Reserach and Treatment 6/2 :101-104,2018

Association analysis of RTEL1 variants with risk of adult gliomas in a Korean population
PLOS ONE 13/11 :207,660-207,669,2018

Radiomic MRI phenotyping of glioblastoma: improving survival prediction
RADIOLOGY 289/3 :797-806,2018

MerTK mediates STAT3-KRAS/SRC-signaling axis for glioma stem cell maintenance
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY 46/s2 :s87-s95,2018

Effect of combined anti-PD-1 and temozolomide therapy in glioblastoma
ONCOIMMUNOLOGY 8/1 :e1525243-e1525253,2019

Clinical predictors of radiation-induced lymphopenia in patients receiving chemoradiation for glioblastoma: clinical usefulness of intensity-modulated radiotherapy in the immuno-oncology era
RADIATION ONCOLOGY 14/1 :51-60,2019

Solitary fibrous tumor/hemangiopericytoma: treatment results based on the 2016 WHO classification
JOURNAL OF NEUROSURGERY 130/2 :418-425,2019

Immune checkpoint inhibitor-induced reinvigoration of tumor-infiltrating CD8+ T cells is determined by their differentiation status in glioblastoma
CLINICAL CANCER RESEARCH 25/8 :2,549-2,559,2019

Targeted next-generation sequencing panel (TruSight Tumor 170) in diffuse glioma: a single institutional experience of 135 cases
JOURNAL OF NEURO-ONCOLOGY 142/3 :445-454,2019

Combined treatment with 2′-hydroxycinnamaldehyde and temozolomide suppresses glioblastoma tumorspheres by decreasing stemness and invasiveness
JOURNAL OF NEURO-ONCOLOGY 143/1 :69-77,2019

Relevance of a TCGA-derived Glioblastoma Subtype Gene-Classifier among Patient Populations
SCIENTIFIC REPORTS 9/1 :7,442-7,442,2019

The Korean Society for Neuro-Oncology (KSNO) guideline for glioblastomas: version 2018.01
Brain Tumor Reserach and Treatment 7/1 :1-9,2019

Re-evaluation of the diagnostic performance of 11C-methionine PET/CT according to the 2016 WHO classification of cerebral gliomas
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 46/8 :1,678-1,684,2019

Transcriptome profiling-based identification of prognostic subtypes and muti-omics signatures of glioblastoma
SCIENTIFIC REPORTS 9/1 :e10555-,2019

Gossypol Suppresses Growth of Temozolomide-Resistant Glioblastoma Tumor Spheres
Biomolecules 9/10 :E595-,2019

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