이인규

  #당뇨병#골다공증

학력

· 경북대학교 의과대학 1982년 졸업
· 석사 - 1983년 경북대학교 대학원
· 박사 - 1988년 경북대학교 대학원

경력

· 1988 ~ 89 미국 하바드의대 조슬린 당뇨센터 연구원
· 1994 ~ 95 미국 하바드의대 조슬린 당뇨센터 연구원
· 1995 ~ 98 계명의대 동산의료원 내분비내과 내분비내과 분과장 부교수
· 1998 ~ 05 계명의대 동산의료원 내분비내과 내분비내과 분과장 교수
· 2005 ~ 현재 경북의대 내분비내과 내분비내과분과장 교수
· 2005. 4. 1 ~ 현재 경북대학교 의과대학 내분비 내과학교수
· 2005. 4. 20 ~ 현재 경북대학병원 내분비내과 분과장

논문

MEDIATORS OF INFLAMMATION Protective Effects of Gemigliptin, a Dipeptidyl Peptidase-4 Inhibitor, against Cisplatin-Induced Nephrotoxicity in Mice

CELL REPORTS A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY Gemigliptin ameliorates Western-diet-induced metabolic syndrome in mice

KIDNEY INTERNATIONAL Pyruvate dehydrogenase kinase 4 deficiency attenuates cisplatin-induced acute kidney injury

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY Protective effects of 1,2,3-triazole derivative KPR-A020 against cisplatin-induced ototoxicity in murine cochlear cultures

Yeungnam University Journal of Medicine The relationship between muscle mitochondrial nutritional overloading and insulin resistance

Diabetes Low-Dose Persistent Organic Pollutants Impair Insulin Secretory Function of Pancreatic Beta-Cells: Human and in Vitro Evidence.

Endocrinology and Metabolism Mechanisms of Vascular Calcification: The Pivotal Role of Pyruvate Dehydrogenase Kinase 4

Diabetes Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis.

KIDNEY INTERNATIONAL Fyn deficiency attenuates renal fibrosis by inhibition of phospho-STAT3

MEDIATORS OF INFLAMMATION Role of Mitochondria-Associated Endoplasmic Reticulum Membrane in Inflammation-Mediated Metabolic Diseases

DIABETES OBESITY & METABOLISM Fibroblast growth factor 21 analogue LY2405319 lowers blood glucose in streptozotocin-induced insulin-deficient diabetic mice by restoring brown adipose tissue function

EXPERIMENTAL AND MOLECULAR MEDICINE Scoparone interferes with STAT3-induced proliferation of vascular smooth muscle cells

HEPATOLOGY Retinoic Acid-Related Orphan Receptor Alpha Reprograms Glucose Metabolism in Glutamine-Deficient Hepatoma Cells

NATURE COMMUNICATIONS Regulation of systemic energy homeostasis by serotonin in adipose tissues

CELLULAR SIGNALLING Non-receptor tyrosine kinase inhibitors enhances beta-cell survival by suppressing the PKC delta signal transduction pathway in streptozotocin - induced beta-cell apoptosis

CANCER LETTERS Colorectal cancer-derived tumor spheroids retain the characteristics of original tumors

VASCULAR PHARMACOLOGY Dipeptidyl peptidase-4 inhibition by gemigliptin prevents abnormal vascular remodeling via NF-E2-related factor 2 activation

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY Estrogen-Related Receptor gamma Plays a Key Role in Vascular Calcification Through the Upregulation of BMP2 Expression

Scientific Reports Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation

REDOX BIOLOGY Dimethylfumarate attenuates restenosis after acute vascular injury by cell-specific and Nrf2-dependent mechanisms

CURRENT MEDICINAL CHEMISTRY Physiological Effect and Therapeutic Application of Alpha Lipoic Acid

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS The physiological roles of apolipoprotein J/clusterin in metabolic and cardiovascular diseases

Diabetes and Metabolism Journal The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity

PLOS ONE Clusterin/Apolipoprotein J Attenuates Angiotensin II-Induced Renal Fibrosis

ENDOCRINOLOGY Orphan Nuclear Receptor Nur77 Mediates Fasting-Induced Hepatic Fibroblast Growth Factor 21 Expression

VASCULAR PHARMACOLOGY Activation of Nrf2 by dimethyl fumarate improves vascular calcification

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Alpha lipoic acid induces hepatic fibroblast growth factor 21 expression via up-regulation of CREBH

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin Resistance

DIABETOLOGIA cAMP response element binding protein H mediates fenofibrate-induced suppression of hepatic lipogenesis

Endocrinology and Metabolism Clinical Characteristics for 348 Patients with Adrenal Incidentaloma

DIABETES RESEARCH AND CLINICAL PRACTICE Association of 11 beta-hydroxysteroid dehydrogenase type 1 gene polymorphisms with serum alanine aminotransferase activity

PLOS ONE Dimethylfumarate Suppresses Adipogenic Differentiation in 3T3-L1 Preadipocytes through Inhibition of STAT3 Activity

DIABETES RESEARCH AND CLINICAL PRACTICE Serum irisin levels in new-onset type 2 diabetes

ENDOCRINOLOGY Clusterin Decreases Hepatic SREBP-1c Expression and Lipid Accumulation

PLOS ONE Scoparone Exerts Anti-Tumor Activity against DU145 Prostate Cancer Cells via Inhibition of STAT3 Activity

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Clusterin Attenuates the Development of Renal Fibrosis

EXPERIMENTAL DIABETES RESEARCH Guards and Culprits in the Endoplasmic Reticulum: Glucolipotoxicity and beta-Cell Failure in Type II Diabetes

Life Sci. Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL/6 mice.

FREE RADICAL BIOLOGY AND MEDICINE Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-beta/Smad signaling

J Cell Mol Med Alpha-lipoic acid attenuates vascular calcification via reversal of mitochondrial function and restoration of Gas6/Axl/Akt survival pathway

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Mediation of glucolipotoxicity in INS-1 rat insulinoma cells by small heterodimer partner interacting leucine zipper protein (SMILE)

The Korean Journal of Internal Medicine An Emerging Diabetes Mellitus Diagnosis Modality: HbA1c

DIABETES RESEARCH AND CLINICAL PRACTICE Association of the DDAH2 gene polymorphism with type 2 diabetes and hypertension

Diabetes and Metabolism Journal Transcriptional Regulation of Pyruvate Dehydrogenase Kinase

PLoS One. Dimethylfumarate Attenuates Renal Fibrosis via NF-E2-Related Factor 2-Mediated Inhibition of Transforming Growth Factor-β/Smad Signaling

Endocrine Journal Relationship of 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase gene polymorphisms with metabolic syndrome and type 2 diabetes

EXPERIMENTAL AND MOLECULAR MEDICINE Orphan nuclear receptor small heterodimer partner inhibits angiotensin II- stimulated PAI-1 expression in vascular smooth muscle cells

ENDOCRINOLOGY Endoplasmic Reticulum Stress-Induced Activation of Activating Transcription Factor 6 Decreases cAMP-Stimulated Hepatic Gluconeogenesis via Inhibition of CREB

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Alpha-lipoic acid inhibits hepatic PAI-1 expression and fibrosis by inhibiting the TGF-beta signaling pathway

DIABETES RESEARCH AND CLINICAL PRACTICE Impact of ENPP1 and MMP3 gene polymorphisms on aortic calcification in patients with type 2 diabetes in a Korean population

ENDOCRINE JOURNAL Relationship between cardiovascular autonomic neuropathy and coronary artery calcification in patients with type 2 diabetes

JOURNAL OF DIABETES INVESTIGATION Trend analysis of diabetic prevalence and incidence in a rural area of South Korea between 2003-2008

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY alpha-Lipoic Acid Prevents Neointimal Hyperplasia Via Induction of p38 Mitogen-Activated Protein Kinase/Nur77-Mediated Apoptosis of Vascular Smooth Muscle Cells and Accelerates Postinjury Reendothelialization

EXPERIMENTAL AND MOLECULAR MEDICINE Fabrication of an alpha-lipoic acid-eluting poly-(D,L-lactide-co-caprolactone) cuff for the inhibition of neointimal formation

CIRCULATION RESEARCH Activation of NAD(P) H:Quinone Oxidoreductase 1 Prevents Arterial Restenosis by Suppressing Vascular Smooth Muscle Cell Proliferation

The Korean Journal of Internal Medicine Novel LMNA Gene Mutation in a Patient With Atypical Werner’s Syndrome

ENDOCRINE JOURNAL Novel Mutation of Aquaporin-2 Gene in a Patient with Congenital Nephrogenic Diabetes Insipidus

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY The Orphan Nuclear Receptor SHP Attenuates Renal Fibrosis

KOREAN DIABETES JOURNAL 제2형 당뇨병환자에서 요 알부민 크레아티닌 비와 관상동맥 석회화와의 관련성

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Forkhead transcription factor FoxO1 inhibits insulin- and transforming growth factor-beta-stimulated plasminogen activator inhibitor-1 expression

KOREAN DIABETES JOURNAL Leptin is Negatively Associated with Femoral Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes Mellitus

KOREAN DIABETES JOURNAL Leptin is Negatively Associated with Femoral Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes Mellitus

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY Protective Role of Clusterin/Apolipoprotein J Against Neointimal Hyperplasia via Antiproliferative Effect on Vascular Smooth Muscle Cells and Cytoprotective Effect on Endothelial Cells

ATHEROSCLEROSIS Cilostazol inhibits high glucose- and angiotensin II-induced type 1 plasminogen activator inhibitor expression in artery wall and neointimal region after vascular injury

KOREAN DIABETES JOURNAL 한국인에서 PSMA6 (rs1048990)와 PSMB5 (rs2230087) 유전자 다형성과제2형 당뇨병과의 연관성

ENDOCRINOLOGY Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases insulin gene expression via up-regulation of orphan nuclear receptor small heterodimer partner

HEPATOLOGY Alpha-Lipoic Acid Decreases Hepatic Lipogenesis Through Adenosine Mono phosphate-Activated Protein Kinase (AMPK)-Dependent and AMPK-Independent Pathways

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Glucocorticoid receptor mediated repression of human insulin gene expression is regulated by PGC-1 alpha

EXPERIMENTAL AND MOLECULAR MEDICINE alpha-Lipoic acid inhibits matrix metalloproteinase-9 expression by inhibiting NF-kappa B transcriptional activity

DIABETES Glucotoxicity in the INS-1 rat insulinoma cell line is mediated by the orphan nuclear receptor small heterodimer partner

Antioxid Redox Signal Effects of PGC-1 alpha at on TNF-alpha-induced MCP-1 and VCAM-1 expression and NF-kappa B activation in human aortic smooth muscle and endothelial cells

KOREAN DIABETES JOURNAL INS-1 세포에서 SHP에 의해 유도된 유전자발현의 변화에 대한 마이크로어레이 분석

DIABETES RESEARCH AND CLINICAL PRACTICE The modulating effects of the overexpression of uncoupling protein 2 on the formation of reactive oxygen species in vascular cells

KOREAN DIABETES JOURNAL 한국인에서 제2형 당뇨병과 Kir6.2 및 Peroxisome Proliferator -activated Receptor-gamma (PPARγ) 유전자 다형성의 연관성

GENE THERAPY Liver-directed gene therapy of diabetic rats using an HVJ-E vector containing EBV plasmids expressing insulin and GLUT 2 transporter

Diabetes and Metabolism Journal Endoplasmic Reticulum (ER) 스트레스와 혈관 합병증

TRANSPLANTATION PROCEEDINGS Effect of AP-1 decoy using hemagglutinating virus of Japan-liposome on the intimal hyperplasia of the autogenous vein graft in mongrel dogs

ATHEROSCLEROSIS Alpha-lipoic acid inhibits fractalkine expression and prevents neointimal hyperplasia after balloon injury in rat carotid artery

LIFE SCIENCES The ascochlorin derivative, AS-6, inhibits TNF-alpha-induced adhesion molecule and chemokine expression in rat vascular smooth muscle cells

TRANSPLANTATION PROCEEDINGS E2F decoy oligodeoxynucleotides on neointimal hyperplasia in canine vein graft

Gene therapy Molecular Biology Circular dumbbell AP-1 and E2F decoy oligodeoxynucleotide based antiproliferative gene therapy

HYPERTENSION Cilostazol inhibits vascular smooth muscle cell growth by downregulation of the transcription factor E2F

Journal of Exercise Nutrition & Biochemistry 비만 흰쥐의 6주간 식이제한 및 트레드밀 운동 후 혈중 대사기질, 호르몬 및 사이토카인 농도의 변화

DIABETOLOGIA The effects of the overexpression of recombinant uncoupling protein 2 on proliferation, migration and plasminogen activator inhibitor 1 expression in human vascular smooth muscle cells

Diabetes and Metabolism Journal 폐경 전 여성에서 비만도에 따른 혈중 렙틴 농도와 대사증후군 관련인자와의 상관관계 비교

CIRCULATION RESEARCH Effects of recombinant adenovirus-mediated uncoupling protein 2 overexpression on endothelial function and apoptosis

운동과학 식이와 운동의 복합 처치후 운동부하에 따른 비만 흰쥐의 혈중 대사기질, 호르몬 및 사이토카인 농도의 변화

KOREAN DIABETES JOURNAL 백서의 혈관평활근세포에서 알파-리포산(alpha-lipoic acid)이 종양괴사인자-알파에 유도된 Fractalkine 발현에 미치는 효과

대한스포츠의학회지 성인 여성의 비만여부에 따른 신체구성 및 경구당부하검사 비교

DIABETES RESEARCH AND CLINICAL PRACTICE Relationship between serum adiponectin and leptin concentrations and body fat distribution

대한내과학회지 폐경 전 비만여성에서 내장지방량에 따른 혈중 아디포넥틴 농도와 대사증후군 관련인자와의 상관관계

GENE THERAPY Transcription factor decoy for AP-1 reduces mesangial cell proliferation and extracellular matrix production in vitro and in vivo

대한내분비학회지 대사조절과 PGC-1α

PROTEOMICS Analysis of proteome and transcriptome of tumor necrosis factor alpha stimulated vascular smooth muscle cells with or without alpha lipoic acid

DIABETES RESEARCH AND CLINICAL PRACTICE Prevention and treatment of macroangiopathy: focusing on oxidative stress

한국지질동맥경화학회지 제2형 당뇨병 환자에서 Cerivastatin 단기 투여가 혈관내피세포 기능에 미치는 영향

대한재활의학회지 뇌졸중 편마비 환자의 골밀도

대한내분비학회지 베타3-아드레날린성 수용체 유전자 변이와 체지방 분포

KOREAN DIABETES JOURNAL 스트렙토조토신 유발 당뇨병 백서에서 HVJ-리포좀과 Epstein-Barr Virus Plasmid를 이용한 인슐린 유전자 치료

JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM Selective beta-cell loss and beta-cell expansion in patients with type 2 diabetes mellitus in Korea

CURRENT DRUG TARGETS Advantages of the circular dumbbell decoy in gene therapy and studies of gene regulation

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE Endothelial dysfunction: its relationship with acute hyperglycaemia and hyperlipidemia

GENE THERAPY Novel E2F decoy oligodeoxynucleotides inhibit in vitro vascular smooth muscle cell proliferation and in vivo neointimal hyperplasia

Medical Postgraduates 당뇨병성 만성 합병증과 식후고혈당의 새로운 조명

대한비만학회지 지방세포의 역할과 랩틴수용체의 다형성(Role of Adipocyte & Leptin Receptor Polymorphism)

당뇨병 혈관 내피세포 기능 평가

대한소아내분비학회지 하시모토갑상선염의 병리기전

당뇨병 혈관질환에 대한 분자생물학적치료

대한당뇨병학회지 Glucose-Induced Protein Kinase C Activation Regulates Vascular Permeability Factor mRNA Expression and Peptide Production by Human Vascular Smooth Mus

계명의대논문집 당뇨병 혈관합병증 발생기전으로 세포사의 역할 및 신호전달체계의 이상

계명의대논문집 당뇨병 혈관합병증 발생기전으로 세포사의 역할 및 신호전달체계의 이상

대한당뇨병학회지 당뇨병 합병증에서 미세혈관 및 세포외 기질의 이상

저서

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보도자료

이인규 교수 당뇨병 치료 선도
http://www.idaegu.com/newsView/idg201901240101

대구첨복재단, 금 나노 의약품 및 종양광열치료 기술 개발
http://medipana.com/news/news_viewer.asp?NewsNum=238920&MainKind=A&NewsKind=5&vCount=12&vKind=1

경북대병원 이인규 교수, 당뇨병 치료 가능한 새로운 표적 제시
http://www.nspna.com/news/?mode=view&newsid=332975

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