이혜승
#위암과 대장직장암의 종양병리
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학력
1997 서울대학교 의과대학 의학과 졸업
2000 서울대학교 의과대학원 의학과 석사(병리학)
2002 서울대학교 의과대학원 의학과 박사(병리학)
2000 서울대학교 의과대학원 의학과 석사(병리학)
2002 서울대학교 의과대학원 의학과 박사(병리학)
경력
1998 ~ 2002 서울대학교병원 병리과 전공의
2002 ~ 2003 서울대학교병원 병리과 전임의
2003 ~ 2005 분당서울대학교병원 병리과 전임의
2005 ~ 2012 분당서울대학교병원 병리과 임상조교수
2012 ~ 2017 분당서울대학교병원 병리과 임상부교수
2017 ~ 현재 분당서울대학교병원 병리과 임상교수
2017 ~ 현재 서울대학교 의과대학 병리학교실 기금교수
2002 ~ 2003 서울대학교병원 병리과 전임의
2003 ~ 2005 분당서울대학교병원 병리과 전임의
2005 ~ 2012 분당서울대학교병원 병리과 임상조교수
2012 ~ 2017 분당서울대학교병원 병리과 임상부교수
2017 ~ 현재 분당서울대학교병원 병리과 임상교수
2017 ~ 현재 서울대학교 의과대학 병리학교실 기금교수
논문
Koh J, Lee KW, Nam SK, Seo AN, Kim JW, Kim JW, Park DJ, Kim HH, Kim WH, Lee HS. Development and Validation of an Easy-to-Implement, Practical Algorithm for the Identification of Molecular Subtypes of Gastric Cancer: Prognostic and Therapeutic Implications. Oncologist. 2019 Dec 11;24(12):e1321-e1330. doi: 10.1634/theoncologist.2019-0058.
Koh J, Nam SK, Lee YW, Kim JW, Lee KW, Ock CY, Oh DY, Ahn SH, Kim HH, Kang KW, Kim WH, Lee HY, Lee HS. Trastuzumab Specific Epitope Evaluation as a Predictive and Prognostic Biomarker in Gastric Cancer Patients. Biomolecules. 2019 Nov 26;9(12). pii: E782. doi: 10.3390/biom9120782.
Park Y, Koh J, Kwak Y, Ahn SH, Park DJ, Kim HH, Kim WH, Lee HS. Clinicopathologic significance of human leukocyte antigen class I expression in patients with stage II and III gastric cancer. Cancer Immunol Immunother. 2019 Nov;68(11):1779-1790. doi: 10.1007/s00262-019-02410-z.
Lee KS, Nam SK, Seo SH, Park KU, Oh HK, Kim DW, Kang SB, Kim WH, Lee HS. Digital polymerase chain reaction for detecting c-MYC copy number gain in tissue and cell-free plasma samples of colorectal cancer patients. Sci Rep. 2019 Feb 7;9(1):1611. doi: 10.1038/s41598-018-38415-4. PMID: 30733532
Cheong JH, Yang HK, Kim H, Kim WH, Kim YW, Kook MC, Park YK, Kim HH, Lee HS, Lee KH, Gu MJ, Kim HY, Lee J, Choi SH, Hong S, Kim JW, Choi YY, Hyung WJ, Jang E, Kim H, Huh YM, Noh SH. Predictive test for chemotherapy response in resectable gastric cancer: a multi-cohort, retrospective analysis. Lancet Oncol. 2018 May;19(5):629-638. doi: 10.1016/S1470-2045(18)30108-6.
Yun S, Koh J, Nam SK, Park JO, Lee SM, Lee K, Lee KS, Ahn SH, Park DJ, Kim HH, Choe G, Kim WH, Lee HS. Clinical significance of overexpression of NRG1 and its receptors, HER3 and HER4, in gastric cancer patients. Gastric Cancer. 2018 Mar;21(2):225-236. doi: 10.1007/s10120-017-0732-7.
Kwak Y, Yun S, Nam SK, Seo AN, Lee KS, Shin E, Oh HK, Kim DW, Kang SB, Kim WH, Lee HS. Comparative analysis of the EGFR, HER2, c-MYC, and MET variations in colorectal cancer determined by three different measures: gene copy number gain, amplification status and the 2013 ASCO/CAP guideline criterion for HER2 testing of breast cancer. J Transl Med. 2017 Aug 1;15(1):167. doi: 10.1186/s12967-017-1265-x.
Lee KS, Kwak Y, Ahn S, Shin E, Oh HK, Kim DW, Kang SB, Choe G, Kim WH, Lee HS. Prognostic implication of CD274 (PD-L1) protein expression in tumor-infiltrating immune cells for microsatellite unstable and stable colorectal cancer. Cancer Immunol Immunother. 2017 Jul;66(7):927-939. doi: 10.1007/s00262-017-1999-6.
Koh J, Ock CY, Kim JW, Nam SK, Kwak Y, Yun S, Ahn SH, Park DJ, Kim HH, Kim WH, Lee HS. Clinicopathologic implications of immune classification by PD-L1 expression and CD8-positive tumor-infiltrating lymphocytes in stage II and III gastric cancer patients. Oncotarget. 2017 Apr 18;8(16):26356-26367. doi: 10.18632/oncotarget.15465.
Kwak Y, Koh J, Kim DW, Kang SB, Kim WH, Lee HS. Immunoscore encompassing CD3+ and CD8+ T cell densities in distant metastasis is a robust prognostic marker for advanced colorectal cancer. Oncotarget. 2016 Dec 6;7(49):81778-81790. doi: 10.18632/oncotarget.13207.
Nam KH, Kim MA, Choe G, Kim WH, Lee HS. Deregulation of the cell polarity protein Lethal giant larvae 2 (Lgl2) correlates with gastric cancer progression. Gastric Cancer. 2014 Oct;17(4):610-20. doi: 10.1007/s10120-013-0324-0.
Lee HS, Chen M, Kim JH, Kim WH, Ahn S, Maeng K, Allegra CJ, Kaye FJ, Hochwald SN, Zajac-Kaye M. Analysis of 320 gastroenteropancreatic neuroendocrine tumors identifies TS expression as independent biomarker for survival. Int J Cancer. 2014 Jul 1;135(1):128-37. doi: 10.1002/ijc.28675.
Jeong SY, Park JW, Nam BH, Kim S, Kang SB, Lim SB, Choi HS, Kim DW, Chang HJ, Kim DY, Jung KH, Kim TY, Kang GH, Chie EK, Kim SY, Sohn DK, Kim DH, Kim JS, Lee HS, Kim JH, Oh JH. Open versus laparoscopic surgery for mid-rectal or low-rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): survival outcomes of an open-label, non-inferiority, randomised controlled trial. Lancet Oncol. 2014 Jun;15(7):767-74. doi: 10.1016/S1470-2045(14)70205-0.
Seo AN, Kwak Y, Kim DW, Kang SB, Choe G, Kim WH, Lee HS. HER2 Status in Colorectal Cancer: Its Clinical Significance and the Relationship between HER2 Gene Amplification and Expression. PLoS One. 2014 May 30;9(5):e98528. doi: 10.1371/journal.pone.0098528. eCollection 2014.
Nam SK, Im J, Kwak Y, Han N, Nam KH, Seo AN, Lee HS. Effects of fixation and storage of human tissue samples on nucleic Acid preservation. Korean J Pathol. 2014 Feb;48(1):36-42. doi: 10.4132/KoreanJPathol.2014.48.1.36.
Lee HE, Park KU, Yoo SB, Nam SK, Park DJ, Kim HH, Lee HS. Clinical significance of intratumoral HER2 heterogeneity in gastric cancer. Eur J Cancer. 2013 Apr;49(6):1448-57. doi: 10.1016/j.ejca.2012.10.018.
Ryu HS, Park DJ, Kim HH, Kim WH, Lee HS. Combination of epithelial-mesenchymal transition and cancer stem cell-like phenotypes has independent prognostic value in gastric cancer. Hum Pathol. 2012 Apr;43(4):520-8.
Kim K, Kim YH, Kim SY, Kim S, Lee YJ, Kim KP, Lee HS, Ahn S, Kim T, Hwang SS, Song KJ, Kang SB, Kim DW, Park SH, Lee KH. Low-dose abdominal CT for evaluating suspected appendicitis. N Engl J Med. 2012 Apr 26;366(17):1596-605. PMID: 22533576 DOI: 10.1056/NEJMoa1110734
Lee HE, Park DJ, Kim WH, Kim HH, Lee HS. High FOXP3+ regulatory T-cell density in the sentinel lymph node is associated with downstream non-sentinel lymph-node metastasis in gastric cancer. Br J Cancer. 2011 Jul 26;105(3):413-9. PMID: 21730981 PMCID: PMC3172906 DOI: 10.1038/bjc.2011.248
Lee HS, Park KU, Park JO, Chang HE, Song J, Choe G. Rapid, Sensitive, and Specific Detection of Mycobacterium tuberculosis Complex by Real-Time PCR on Paraffin-Embedded Human Tissues. J Mol Diagn. 2011 Jul;13(4):390-4.
Kang SB, Park JW, Jeong SY, Nam BH, Choi HS, Kim DW, Lim SB, Lee TG, Kim DY, Kim JS, Chang HJ, Lee HS, Kim SY, Jung KH, Hong YS, Kim JH, Sohn DK, Kim DH, Oh JH. Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): short-term outcomes of an open-label randomised controlled trial. Lancet Oncol. 2010 Jul;11(7):637-45. PMID: 20610322 DOI: 10.1016/S1470-2045(10)70131-5
Lee HS, Cho SB, Lee HE, Kim MA, Kim JH, Park do J, Kim JH, Yang HK, Lee BL, Kim WH. Protein expression profiling and molecular classification of gastric cancer by the tissue array method. Clin Cancer Res. 2007 Jul 15;13(14):4154-63.
Lee HS, Choe G, Kim WH, Kim HH, Song J, Park KU. Expression of Lewis antigens and their precursors in gastric mucosa: relationship with Helicobacter pylori infection and gastric carcinogenesis. J Pathol. 2006 May;209(1):88-94
Lee HS, Chang MS, Yang HK, Lee BL, Kim WH. Epstein-Barr virus-positive gastric carcinoma has a distinct protein expression profile in comparison with Epstein-Barr virus-negative carcinoma. Clin Cancer Res 2004 Mar 1;10(5):1698-705
Lee HS, Lee HK, Kim HS, Yang HK, Kim WH. Tumor suppressor gene expression correlates with gastric cancer prognosis. J Pathol 2003 May;200(1):39-46. PMID: 12692839 DOI: 10.1002/path.1288
Lee HS, Choi SI, Lee HK, Kim HS, Yang HK, Kang GH, Kim YI, Lee BL, Kim WH. Distinct clinical features and outcomes of gastric cancers with microsatellite instability. Mod Pathol 2002 Jun;15(6):632-40. PMID: 12065777 DOI: 10.1038/modpathol.3880578
Lee HS, Lee HK, Kim HS, Yang H-K, Kim YI, Kim WH. MUC1, MUC2, MUC5AC, and MUC6 expressions in gastric carcinomas. Cancer 2001 Sep 15;92(6):1427-34.
Lee HS, Lee BL, Kim SH, Woo DK, Kim HS, Kim WH. Microsatellite instability in synchronous gastric carcinomas. Int J Cancer 2001 Mar 1;91(5):619-24.
Koh J, Nam SK, Lee YW, Kim JW, Lee KW, Ock CY, Oh DY, Ahn SH, Kim HH, Kang KW, Kim WH, Lee HY, Lee HS. Trastuzumab Specific Epitope Evaluation as a Predictive and Prognostic Biomarker in Gastric Cancer Patients. Biomolecules. 2019 Nov 26;9(12). pii: E782. doi: 10.3390/biom9120782.
Park Y, Koh J, Kwak Y, Ahn SH, Park DJ, Kim HH, Kim WH, Lee HS. Clinicopathologic significance of human leukocyte antigen class I expression in patients with stage II and III gastric cancer. Cancer Immunol Immunother. 2019 Nov;68(11):1779-1790. doi: 10.1007/s00262-019-02410-z.
Lee KS, Nam SK, Seo SH, Park KU, Oh HK, Kim DW, Kang SB, Kim WH, Lee HS. Digital polymerase chain reaction for detecting c-MYC copy number gain in tissue and cell-free plasma samples of colorectal cancer patients. Sci Rep. 2019 Feb 7;9(1):1611. doi: 10.1038/s41598-018-38415-4. PMID: 30733532
Cheong JH, Yang HK, Kim H, Kim WH, Kim YW, Kook MC, Park YK, Kim HH, Lee HS, Lee KH, Gu MJ, Kim HY, Lee J, Choi SH, Hong S, Kim JW, Choi YY, Hyung WJ, Jang E, Kim H, Huh YM, Noh SH. Predictive test for chemotherapy response in resectable gastric cancer: a multi-cohort, retrospective analysis. Lancet Oncol. 2018 May;19(5):629-638. doi: 10.1016/S1470-2045(18)30108-6.
Yun S, Koh J, Nam SK, Park JO, Lee SM, Lee K, Lee KS, Ahn SH, Park DJ, Kim HH, Choe G, Kim WH, Lee HS. Clinical significance of overexpression of NRG1 and its receptors, HER3 and HER4, in gastric cancer patients. Gastric Cancer. 2018 Mar;21(2):225-236. doi: 10.1007/s10120-017-0732-7.
Kwak Y, Yun S, Nam SK, Seo AN, Lee KS, Shin E, Oh HK, Kim DW, Kang SB, Kim WH, Lee HS. Comparative analysis of the EGFR, HER2, c-MYC, and MET variations in colorectal cancer determined by three different measures: gene copy number gain, amplification status and the 2013 ASCO/CAP guideline criterion for HER2 testing of breast cancer. J Transl Med. 2017 Aug 1;15(1):167. doi: 10.1186/s12967-017-1265-x.
Lee KS, Kwak Y, Ahn S, Shin E, Oh HK, Kim DW, Kang SB, Choe G, Kim WH, Lee HS. Prognostic implication of CD274 (PD-L1) protein expression in tumor-infiltrating immune cells for microsatellite unstable and stable colorectal cancer. Cancer Immunol Immunother. 2017 Jul;66(7):927-939. doi: 10.1007/s00262-017-1999-6.
Koh J, Ock CY, Kim JW, Nam SK, Kwak Y, Yun S, Ahn SH, Park DJ, Kim HH, Kim WH, Lee HS. Clinicopathologic implications of immune classification by PD-L1 expression and CD8-positive tumor-infiltrating lymphocytes in stage II and III gastric cancer patients. Oncotarget. 2017 Apr 18;8(16):26356-26367. doi: 10.18632/oncotarget.15465.
Kwak Y, Koh J, Kim DW, Kang SB, Kim WH, Lee HS. Immunoscore encompassing CD3+ and CD8+ T cell densities in distant metastasis is a robust prognostic marker for advanced colorectal cancer. Oncotarget. 2016 Dec 6;7(49):81778-81790. doi: 10.18632/oncotarget.13207.
Nam KH, Kim MA, Choe G, Kim WH, Lee HS. Deregulation of the cell polarity protein Lethal giant larvae 2 (Lgl2) correlates with gastric cancer progression. Gastric Cancer. 2014 Oct;17(4):610-20. doi: 10.1007/s10120-013-0324-0.
Lee HS, Chen M, Kim JH, Kim WH, Ahn S, Maeng K, Allegra CJ, Kaye FJ, Hochwald SN, Zajac-Kaye M. Analysis of 320 gastroenteropancreatic neuroendocrine tumors identifies TS expression as independent biomarker for survival. Int J Cancer. 2014 Jul 1;135(1):128-37. doi: 10.1002/ijc.28675.
Jeong SY, Park JW, Nam BH, Kim S, Kang SB, Lim SB, Choi HS, Kim DW, Chang HJ, Kim DY, Jung KH, Kim TY, Kang GH, Chie EK, Kim SY, Sohn DK, Kim DH, Kim JS, Lee HS, Kim JH, Oh JH. Open versus laparoscopic surgery for mid-rectal or low-rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): survival outcomes of an open-label, non-inferiority, randomised controlled trial. Lancet Oncol. 2014 Jun;15(7):767-74. doi: 10.1016/S1470-2045(14)70205-0.
Seo AN, Kwak Y, Kim DW, Kang SB, Choe G, Kim WH, Lee HS. HER2 Status in Colorectal Cancer: Its Clinical Significance and the Relationship between HER2 Gene Amplification and Expression. PLoS One. 2014 May 30;9(5):e98528. doi: 10.1371/journal.pone.0098528. eCollection 2014.
Nam SK, Im J, Kwak Y, Han N, Nam KH, Seo AN, Lee HS. Effects of fixation and storage of human tissue samples on nucleic Acid preservation. Korean J Pathol. 2014 Feb;48(1):36-42. doi: 10.4132/KoreanJPathol.2014.48.1.36.
Lee HE, Park KU, Yoo SB, Nam SK, Park DJ, Kim HH, Lee HS. Clinical significance of intratumoral HER2 heterogeneity in gastric cancer. Eur J Cancer. 2013 Apr;49(6):1448-57. doi: 10.1016/j.ejca.2012.10.018.
Ryu HS, Park DJ, Kim HH, Kim WH, Lee HS. Combination of epithelial-mesenchymal transition and cancer stem cell-like phenotypes has independent prognostic value in gastric cancer. Hum Pathol. 2012 Apr;43(4):520-8.
Kim K, Kim YH, Kim SY, Kim S, Lee YJ, Kim KP, Lee HS, Ahn S, Kim T, Hwang SS, Song KJ, Kang SB, Kim DW, Park SH, Lee KH. Low-dose abdominal CT for evaluating suspected appendicitis. N Engl J Med. 2012 Apr 26;366(17):1596-605. PMID: 22533576 DOI: 10.1056/NEJMoa1110734
Lee HE, Park DJ, Kim WH, Kim HH, Lee HS. High FOXP3+ regulatory T-cell density in the sentinel lymph node is associated with downstream non-sentinel lymph-node metastasis in gastric cancer. Br J Cancer. 2011 Jul 26;105(3):413-9. PMID: 21730981 PMCID: PMC3172906 DOI: 10.1038/bjc.2011.248
Lee HS, Park KU, Park JO, Chang HE, Song J, Choe G. Rapid, Sensitive, and Specific Detection of Mycobacterium tuberculosis Complex by Real-Time PCR on Paraffin-Embedded Human Tissues. J Mol Diagn. 2011 Jul;13(4):390-4.
Kang SB, Park JW, Jeong SY, Nam BH, Choi HS, Kim DW, Lim SB, Lee TG, Kim DY, Kim JS, Chang HJ, Lee HS, Kim SY, Jung KH, Hong YS, Kim JH, Sohn DK, Kim DH, Oh JH. Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): short-term outcomes of an open-label randomised controlled trial. Lancet Oncol. 2010 Jul;11(7):637-45. PMID: 20610322 DOI: 10.1016/S1470-2045(10)70131-5
Lee HS, Cho SB, Lee HE, Kim MA, Kim JH, Park do J, Kim JH, Yang HK, Lee BL, Kim WH. Protein expression profiling and molecular classification of gastric cancer by the tissue array method. Clin Cancer Res. 2007 Jul 15;13(14):4154-63.
Lee HS, Choe G, Kim WH, Kim HH, Song J, Park KU. Expression of Lewis antigens and their precursors in gastric mucosa: relationship with Helicobacter pylori infection and gastric carcinogenesis. J Pathol. 2006 May;209(1):88-94
Lee HS, Chang MS, Yang HK, Lee BL, Kim WH. Epstein-Barr virus-positive gastric carcinoma has a distinct protein expression profile in comparison with Epstein-Barr virus-negative carcinoma. Clin Cancer Res 2004 Mar 1;10(5):1698-705
Lee HS, Lee HK, Kim HS, Yang HK, Kim WH. Tumor suppressor gene expression correlates with gastric cancer prognosis. J Pathol 2003 May;200(1):39-46. PMID: 12692839 DOI: 10.1002/path.1288
Lee HS, Choi SI, Lee HK, Kim HS, Yang HK, Kang GH, Kim YI, Lee BL, Kim WH. Distinct clinical features and outcomes of gastric cancers with microsatellite instability. Mod Pathol 2002 Jun;15(6):632-40. PMID: 12065777 DOI: 10.1038/modpathol.3880578
Lee HS, Lee HK, Kim HS, Yang H-K, Kim YI, Kim WH. MUC1, MUC2, MUC5AC, and MUC6 expressions in gastric carcinomas. Cancer 2001 Sep 15;92(6):1427-34.
Lee HS, Lee BL, Kim SH, Woo DK, Kim HS, Kim WH. Microsatellite instability in synchronous gastric carcinomas. Int J Cancer 2001 Mar 1;91(5):619-24.
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