이근욱

  #소화기암#두경부암의 항암화학요법#고형암의 임상시험

학력

서울대학교 의학과 졸업 (1998)
서울대학교 의과대학원 내과학 석사 (2004)
서울대학교 의과대학원 분자종양학 박사 (2007)

경력

서울대학교병원 내과 전공의 (2000-2004)
서울대학교병원 혈액종양내과 전임의 (2004-2005)
분당서울대학교병원 혈액종양내과 전임강사 (2005-2006)
분당서울대학교병원 혈액종양내과 조교수 (2006-2012)
분당서울대학교병원 혈액종양내과 부교수 (2012-2018)
미국 MD Anderson Cancer Center 연수 (2012-2013)
분당서울대학교병원 혈액종양내과 교수 (2018-현재)
분당서울대학교병원 임상시험센터장 (2020-현재)

논문

Chang HJ, Lee KW, Kim JH, Bang SM, Kim YJ, Kim DW, Kang SB, Lee JS. Adjuvant capecitabine chemotherapy using a tailored-dose strategy in elderly patients with colon cancer. Ann Oncol 2012 Apr;23(4):911-8 : 완치적 수술을 시행받은 70세 이상의 노인 대장암 환자들을 대상으로 경구 항암제인 젤로다(Xeloda; Capecitabine)를 개별적 맞춤 용량 투약방법을 사용하여 투약한 경우 부작용도 최소화하면서 항암 효능도 잘 유지할 수 있음을 보여준 세계 최초의 연구 [교신 저자]
Lee KW, Bang SM, Kim S, Lee HJ, Shin DY, Koh Y, Lee YG, Cha Y, Kim YJ, Kim JH, Park DJ, Kim HH, Oh D, Lee JS. The incidence, risk factors and prognostic implications of venous thromboembolism in patients with gastric cancer. J Thromb Haemost 2010;8(3)540-7 : 대규모의 위암 환자들을 대상으로 정맥혈전증의 발생 현황과 예후에 미치는 영향을 분석한 세계 최초의 연구 [제 1 저자]
Lee KW, Kim SG, Kim HP, Kwon E, You J, Choi H, Park JH, Kang BC, Im SA, Kim TY, Kim WH, Bang YJ. Enzastaurin, a protein kinase Cβ inhibitor, suppresses signaling through the ribosomal S6 kinase and Bad pathways and induces apoptosis in human gastric cancer cells. Cancer Res 2008;68(6):1916-26 : 새로운 항암제인 enzastaurin의 위암에서의 작용 가능성을 탐색하고, 기존에 알려지지 않았던 enzastaurin의 새로운 항암 기전을 규명한 연구 [제 1 저자]
[SCI(E) journals: 국제 학술지]
1. Lee KW, Kim DY, Yun T, Kim DW, Kim TY, Yoon SS, Heo DS, Bang YJ, Park S, Kim BK, Kim NK. Doxorubicin-based chemotherapy for diffuse large B-cell lymphoma in elderly patients: comparison of treatment outcomes between young and elderly patients and the significance of doxorubicin dosage. Cancer 2003;98(12):2651-6
2. Lee DH, Kim I, Song HH, Jung JY, Kim DY, Lee KW, Kim TY, Heo DS, Bang YJ, Ha SW, Park JG, Kim NK. Induction chemotherapy followed by radiotherapy in the treatment of anal cancer. Oncol Rep 2003;10(1):101-4
3. Kim DY, Lee KW, Yun T, Park SR, Jung JY, Kim DW, Kim TY, Heo DS, Bang YJ, Kim NK. Comparison of intrathecal chemotherapy for leptomeningeal carcinomatosis of a solid tumor: methotrexate alone versus methotrexate in combination with cytosine arabinoside and hydrocortisone. Jpn J Clin Oncol 2003;33(12):608-12
4. Lee KW, Chon SB, Kim DY, Yun T, Yoon SS, Park S, Kim BK, Kim NK. Adrenal cortical carcinoma initially presented with overwhelming disseminated intravascular coagulation. Ann Hematol 2003;82(9):596-8
5. Lee KW, Choi IS, Roh EY, Kim DY, Yun T, Lee DS, Yoon SS, Park S, Kim BK, Kim NK. Adult patients with t(8;21) acute myeloid leukemia had no superior treatment outcome to those without t(8;21): a single institution's experience. Ann Hematol 2004;83(4):218-24
6. Lee KW, Yi J, Yun T, Kim DY, Lee DS, Park SS, Cho HI, Yoon SS, Park S, Kim BK, Kim NK. Extramedullary relapse confirmed by fluorescence in situ hybridization study of an ear mass in acute promyelocytic leukemia. Int J Hematol 2004;79(5):462-4
7. Lee KD, Lee KW, Choi IS, Yoon SS, Park S, Kim BK, Kim NK. Multicentric Castleman's disease complicated by tumor lysis syndrome. Ann Hematol 2004;83(11):722-5
8. Lee KW, Im SA, Yun T, Song EK, Na I, Shin H, Choi IS, Oh DY, Kim JH, Kim DW, Kim TY, Lee JS, Heo DS, Bang YJ, Kim NK. Phase II trial of low-dose paclitaxel and cisplatin in patients with advanced gastric cancer. Jpn J Clin Oncol 2005;35(12):720-6
9. Lee KW, Yun T, Song EK, Na II, Shin H, Bang SM, Lee JH, Lee ST, Kim JH, Yoon SS, Lee JS, Park S, Kim BK, Kim NK. A pilot study of bortezomib in Korean patients with relapsed or refractory myeloma. J Korean Med Sci 2005;20(4):598-62
10. Kim JH, Lee KW, Jung Y, Kim TY, Ham HS, Jong HS, Jung KH, Im SA, Kim TY, Kim NK, Bang YJ. Cytotoxic effects of pemetrexed in gastric cancer cells Cancer Sci 2005;96(6):365-71
11. Kim DY, Lee KW, Yun T, Kim DW, Kim TY, Heo DS, Bang YJ, Kim NK. Efficacy of platinum-based chemotherapy after cranial radiation in patients with brain metastasis from non-small cell lung cancer. Oncol Rep 2005;14(1):207-11
12. Lee KW, Kim JH, Park JH, Kim HP, Song SH, Kim SG, Kim TY, Jong HS, Jung KH, Im SA, Kim TY, Kim NK, Bang YJ. Antitumor Activity of SK-7041, a Novel Histone Deacetylase Inhibitor, in Human Lung and Breast Cancer Cells. Anticancer Res 2006;26(5A):3429-38
13. Lee KW, Yun T, Kim DW, Im SA, Kim TY, Yoon SS, Heo DS, Bang YJ, Park S, Kim BK, Kim NK. First-line ifosfamide, methotrexate, etoposide and prednisolone chemotherapy ± radiotherapy is active in stage I/II extranodal NK/T-cell lymphoma. Leukemia & Lymphoma 2006;47(7):1274-82
14. Lee KW, Kim JH, Yun T, Song EK, Na II, Shin H, Oh SY, Choi IS, Oh DY, Kim DW, Im SA, Kim TY, Lee JS, Heo DS, Bang YJ, Kim NK. Phase II Study of Low-dose Paclitaxel and Cisplatin as a Second-line Therapy after 5-Fluorouracil/Platinum Chemotherapy in Gastric Cancer. J Korean Med Sci 2007;22(Suppl):S115-S121
15. Kim DY, Lee KE, Nam EM, Lee HR, Lee KW, Kim JH, Lee JS, Lee SN. Do-not-resuscitate orders for terminal patients with cancer in teaching hospitals of Korea. J Palliat Med 2007;10(5):1153-8
16. Yun T, Lee KW, Song EG, Na II, Shin HC, Yoon SS, Park SY, Kim BK, Lee JH, Choi SJ, Lee JH, Lee KH. Non-myeloablative allogeneic stem cell transplantation for metastatic renal cell carcinoma. Clin Transplant 2007;21(3);337-43
17. Ku YH, Lee KW, Kim JH, Ko H, Lee HS, Choe G, Kim YH. Metastatic gastric carcinoma in a 19-year-old man. J Clin Oncol 2007;25(31);5026-8
18. Seo MD, Lee KW, Lim JH, Yi HG, Kim DY, Oh DY, Kim JH, Im SA, Kim TY, Lee JS, Bang YJ. Irinotecan combined with 5-fluorouracil and leucovorin as second-line chemotherapy for metastatic or relapsed gastric cancer. Jpn J Clin Oncol 2008;38(9):589-95
19. Lee KW, Lim JH, Kim JH, Lee CT, Lee JS. Weekly Low-Dose Docetaxel for Salvage Chemotherapy in Pretreated Elderly or Poor Performance Status Patients with Non-small Cell Lung Cancer. J Korean Med Sci 2008;23(6);992-8
20. Oh SY, Kim JH, Lee KW, Bang SM, Hwang JH, Oh D, Lee JS. Venous thromboembolsim in patients with pancreatic adenocarcinoma: Lower incidence in Asian ethinicity. Thromb Res 2008;122(4):485-490
21. Kim YJ, Im SA, Kim HG, Oh SY, Lee KW, Choi IS, Oh DY, Lee SH, Kim JH, Kim DW, Kim TY, Kim S, Heo DS, Yoon YB, Bang YJ. A phase II trial of S-1 and cisplatin in patients with metastatic or relapsed biliary tract cancer. Ann Oncol 2008;19(1):99-103
22. Song EK, Kim SY, Kim TM, Lee KW, Yun T, Na II, Shin H, Lee SH, Kim DW, Khwarg SI, Heo DS. Efficacy of chemotherapy as a first-line treatment in ocular adnexal extranodal marginal zone B-cell lymphoma. Ann Oncol 2008;19(2):242-6
23. Park JH, Jong HS, Kim SG, Jung Y, Lee KW, Lee JH, Kim DK, Bang YJ, Kim TY. Inhibitors of histone deacetylases induce tumor-selective cytotoxicity through modulating Aurora-A kinase. J Mol Med 2008;86(1):117-28
24. Lee KW, Yi J, Choi IS, Kim JH, Bang SM, Kim DW, Im SA, Kim TY, Yoon SS, Lee JS, Bang YJ, Park S, Kim BK, Cho HI, Heo DS. Risk factors for poor treatment outcome and central nervous system relapse in diffuse large B-cell lymphoma with bone marrow involvement. Ann Hematol 2009;88(9):829-38
25. Kim HJ, Lee KW, Kim YJ, Oh DY, Kim JH, Im SA, Lee JS. Chemotherapy-induced transient CEA and CA19-9 surges in patients with metastatic or recurrent gastric cancer. Acta Oncol 2009;48(3):385-90
26. Han HS, Kim JS, Park JH, Jeon YK, Lee KW, Oh DY, Kim JH, Park SY, Im SA, Kim TY, Park IA, Bang YJ. Weekly paclitaxel and trastuzumab as a first-line therapy in patients with HER2-overexpressing metastatic breast cancer: magnitude of HER2/neu amplification as a predictive factor for efficacy. J Korean Med Sci 2009;24(5):910-7
27. Lee JO, Lee KW, Oh DY, Kim JH, Im SA, Kim TY, Bang YJ. Combination chemotherapy with capecitabine and cisplatin for patients with metastatic hepatocellular carcinoma. Ann Oncol 2009;20(8):1402-7
28. Han SW, Oh DY, Im SA, Park SR, Lee KW, Song HS, Lee NS, Lee KH, Choi IS, Lee MH, Kim MA, Kim WH, Bang YJ, Kim TY. Phase II study and biomarker analysis of cetuximab combined with modified FOLFOX6 in advanced gastric cancer. Br J Cancer 2009;100(2):298-304
29. Sun JM, Lee KW, Kim JH, Kim YJ, Yoon HI, Lee JH, Lee CT, Lee JS. Efficacy and Toxicity of Pemetrexed as a Third-line Treatment for Non-small Cell Lung Cancer. Jpn J Clin Oncol 2009;39(1):27-32
30. Han HS, Lee KW, Kim JH, Kim SW, Kim IA, Oh DY, Im SA, Bang SM, Lee JS. Weight changes after adjuvant treatment in Korean women with early breast cancer. Breast Cancer Res 2009;114(1):147-53
31. Choi IS, Lee KW, Kim KH, Kim YJ, Kim JH, Lee JS. Three-Weekly S-1 plus cisplatin chemotherapy as first-line treatment for advanced gastric cancer. Med Oncol 2010 Jan 14
32. Han SW, Oh DY, Im SA, Park SR, Lee KW, Song HS, Lee NS, Lee KH, Choi IS, Lee MH, Kim MA, Kim WH, Bang YJ, Kim TY. Epidermal growth factor receptor intron 1 CA dinucleotide repeat polymorphism and survival of advanced gastric cancer patients treated with cetuximab plus modified FOLFOX6. Cancer Sci 2010;101(3):793-9
33. Kim JH, Lee KW, Kim YH, Lee KH, Oh do Y, Kim J, Yang SH, Im SA, Choi SH, Bang YJ. Individualized tumor response testing for prediction of response to Paclitaxel and Cisplatin chemotherapy in patients with advanced gastric cancer. J Korean Med Sci 2010;25(5):684-90
34. Kwon JH, Kim YJ, Lee KW, Oh DY, Park SY, Kim JH, Chie EK, Kim SW, Im SA, Kim IA, Kim TY, Park IA, Noh DY, Bang YJ, Ha SW. Triple negativity and young age as prognostic factors in lymph node-negative invasive ductal carcinoma of 1 cm or less. BMC Cancer 2010 Oct15;10:557
35. Choi IS, Lee HS, Lee KW, Kim H, Kim KH, Kim YJ, Kim JH, Kim WH, Lee JS. Biomarker analysis in patients with advanced gastric cancer treated with S-1 plus cisplatin chemotherapy: orotate phosphoribosyltransferase expression is associated with treatment outcomes. Med Oncol 2010; 28(4):991-8
36. Choi S, Lee KW, Bang SM, Kim S, Lee JO, Kim YJ, Kim JH, Park YS, Kim DW, Kang SB, Kim JS, Oh D, Lee JS. Different characteristics and prognostic impact of deep-vein thrombosis / pulmonary embolism and intraabdominal venous thrombosis in colorectal cancer patients. Thromb Haemost 2011;106(60:1084-94
37. Kim KH, Lee KW, Baek SK, Chang HJ, Kim YJ, Park DJ, Kim JH, Kim HH, Lee JS. Survival benefit of gastrectomy ± metastasectomy in patients with metastatic gastric cancer receiving chemotherapy. Gastric Cancer 2011;14(2):130-8
38. Beom SH, Lee KW, Yang Y, Choi Y, Song KH, Kim YJ, Kim JH, Bang SM, Chung JH, Lee JS. Metastatic adrenocortical carcinoma presenting simultaneously with Cushing's and Conn's syndromes: a case report. Jpn J Clin Oncol 2011; 41(11):1287-91
39. Lee KW, Kim YJ, Kim JH, Bang SM, Chung JH, Lee JS. Two Consecutive Cases of Platinum-Refractory Pulmonary Pleomorphic Carcinoma that showed Dramatic Responses to MAID (Mesna, Doxorubicin, Ifosfamide and Dacarbazine) Chemotherapy. Jpn J Clin Oncol 2011; 41(3):430-3.
40. Kim YJ, Kim JH, Park MS, Lee KW, Kim KI, Bang SM, Lee JS, Kim CH. Comprehensive geriatric assessment in Korean elderly cancer patients receiving chemotherapy. J Cancer Res Clin Oncol 2011;137(5):839-47
41. Jang NY, Kang SB, Kim DW, Kim JH, Lee KW, Kim IA, Kim JS. The role of carcinoembryonic antigen after neoadjuvant chemoradiotherapy in patients with rectal cancer. Dis Colon Rectum 2011; 54(2):245-52
42. Park HK, Lee KR, Kim YJ, Cho HI, Eun Kim J, Woong Kim K, Jung Kim Y, Lee KW, Hyun Kim J, Bang SM, Lee JS. Prevalence of monoclonal gammopathy of undetermined significance in an elderly urban Korean population. Am J Hematol 2011; 86(9):752-5
43. Oh DY, Lee KW, Lee KH, Sohn CH, Park YS, Zang DY, Ryoo HM, Song HS, Kim JS, Kang HJ, Kim BS, Bang YJ. A phase II trial of erlotinib in combination with gemcitabine and capecitabine in previously untreated metastatic/recurrent pancreatic cancer: combined analysis with translational research. Invest New Drugs 2011 [Epub ahead of print]
44. Park JH, Kim YJ, Lee JO, Lee KW, Kim JH, Bang SM, Chung JH, Kim JS, Lee JS. Clinical outcomes of leptomeningeal metastasis in patients with non-small cell lung cancer in the modern chemotherapy era. Lung Cancer 2011 [Epub ahead of print]
45. Bang YJ, Kim YW, Yang HK, Chung HC, Park YK, Lee KH, Lee KW, Kim YH, Noh SI, Cho JY, Mok YJ, Kim YH, Ji J, Yeh TS, Button P, Sirzen F, Noh SH; for the CLASSIC trial investigators. Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial. Lancet 2012 [Epub ahead of print]
[ Korean domestic journals ]
1. Joh YH, Choi IS, Lee KW, Oh DY, Kim BS, Lee DH, Kim TY, Heo DS, Bang YJ, Wu HG, Sung MW, Lee CH, Kim KH, Kim NK. The therapeutic effect of neoadjuvant chemotherapy in locally advanced oral cavity cancer. Korean J Head and Neck Surgery 2001;17(2):179-184
2. Kim DY, Lee KW, Yun T, Kim TY, Heo DS, Bang YJ, Kim NK. Renal, gastric, and multiple intestinal metastases of invasive ductal carcinoma of breast. Korean J Med 2003;65(suppl 3):s863-40
3. Lee KW, Yun T, Kim DW, Kim TY, Heo DS, Bang YJ, Kim NK. A case of blastic natural killer cell lymphoma presented as disseminated cutaneous lesions. Korean J Med 2004;66(4);453-7
4. Yoon T, Kim DY, Lee KW, Kim DH, Yoon SS, Park SY, Kim BK. A case of therapy-related acute lymphoblastic leukemia after 131I -treatment for thyroid papillary carcinoma. Korean J Med 2004;66(4);437-
5. Kim DY, Lee SM, Lee KE, Lee HR, Kim JH, Lee KW, Lee JS, Lee SN. An evaluation of nutrition support for terminal cancer patients at teaching hospitals in Korea. Cancer Res Treat 2006;38(4);214-7
6. Na II, Shin H, Song EK, Lee KW, Yun T, Kim JH, Yoon SS, Lee JS, Park S, Kim BK. Graft-Versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation with Non-myeloablative Conditioning: Experiences at a Single Center. Korean J of Hematol 2006;41(2):92~98
7. Shin H, Na II, Yun T, Lee KW, Song EK, Choi IS, Oh DY, Kim JH, Lee JS, Yoon SS, Park S, Kim BK, Kim NK. Acute myelogenous leukemia in the elderly (≥ 60): Restrospective study of 115 patients. Korean J of Int Med 2006;70(2):196~206
8. Choi IS, Oh DY, Kim BS, Lee KW, Kim JH, Lee JS. Oxaliplatin, 5-FU, Folinic Acid as First-line Palliative Chemotherapy in Elderly Patients with Metastatic or Recurrent Gastric Cancer. Cancer Res Treat 2007;39(3);99-103
9. Lee Y, Lee KW, Kim JH, Bang SM, Lee JS, Park BB, Kim WS, Suh CW, Kang JH, Ryoo BY, Lee JH, Shin DB. Epstein-Barr virus-positivity in tumor has no correlation with the clinical outcomes of patients with angioimmunoblastic T-cell lymphoma. Korean J of Int Med 2008;23:30-36
10. Lee HS, Lee WW, Kim DW, Kang SB, Lee KH, Lee KW, Kim JH, Kim SE. Prognostic Significance of Pre-operative FDG-PET in Colorectal Cancer Patients with Hepatic Metastasis. Nucl Med Mol Imaging 2009;43(5):429-35
11. Lim KH, Yoon HI, Kang YA, Lee KW, Kim JH, Bang SM, Lee JH, Lee CT, Lee JS. Severe pulmonary adverse effects in lymphoma patients treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimen plus rituximab. Korean J Intern Med 2010;25(1):86-92.
12. Lim KH, Lee KW, Kim JH, Park SY, Choi SH, Lee JS. Anaplastic thyroid carcinoma initially presented with abdominal cutaneous mass and hyperthyroidism. Korean J Intern Med 2010;25(4):450-3
13. Kim NY, Sun JM, Kim YJ, Lee KW, Kim JH, Bang SM, Kim JW, Jeong SH, Lee JS. Cisplatin-Based Combination Chemotherapy for Advanced Hepatocellular Carcinoma: A Single Center Experience before the Sorafenib Era. Cancer Res Treat 2010;42(4):203-9
14. Lee HJ, Lee YS, Lee KW, Kim SY, Yoon CJ, Shin DY, Lee YG, Choi SY, Kang SG, Kang SB, Kim JH. Efficacy and safety of hepatic arterial infusion of Fluorouracil with leucovorin as salvage treatment for refractory liver metastases from colorectal cancer. Korean J Intern Med 2011; 26(1):82-8.

저서

1. 대장암 예방과 치료 그리고 극복 (2011, 계명대학교 출판부) : 대장암 예방, 치료 및 극복 방법에 대하여 환자와 가족들, 일반인들의 눈높이에 맞춰 자세히 저술한 책. 계명대 동산의료원의 박성대 교수와 분당서울대병원 이근욱 교수가 공동으로 저술하여 출판하였다.
2. 대장암 - 환자 가이드북 (2009; 엘스비어 코리아) : 미국의 OncoLink에서 발간한 가이드북을 번역한 책. 대장암 환자들을 대상으로 흔히 접하는 문제들을 문답식으로 기술하였다 (임상암학회에서 번역출간함).

보도자료

위암 환자 삶의 질 개선 위한 '고식적 항암치료' 효과 증명한 분당서울대병원
http://www.joongboo.com/news/articleView.html?idxno=1328459

분당서울대병원 연구진, '고식적 항암치료' 효과 증명
http://www.kyeonggi.com/news/articleView.html?idxno=2050327

위암에 고식적 화학요법 효과 입증
http://www.incheonilbo.com/news/articleView.html?idxno=929857

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