최형수

  #소아청소년암#양성종양#소아청소년 혈액질환

학력

1992 서울대학교 의과대학 의학과 졸업
1998 서울대학교 의과대학 석사 (소아과학전공)
2003 서울대학교 의과대학 박사 (소아과학전공)

경력

1993-1997 서울대학교병원 소아청소년과 전공의
1997-1999 서울대학교병원 소아청소년과 혈액종양 전임의
1999-2001 강원대학교 의과대학 전임강사
2001-2005 서울대학교병원 촉탁의, 조교수
2005-2007 미국 University of Alabama at Birmingham 암센터 연구원
2007-2016 분당서울대학교병원 조교수, 부교수

논문

종양발생에 중요한 역할을 하는 c-myc 유전자에서 생성되는 m r t l 단백의 성질을 규명한 최초의 연구 Choi H, Jackson NL, Shaw DR, Emanuel PD, Liu YL, Tousson A, Meng Z, Blume SW. mrtl-A translation/localization regulatory protein encoded within the human c-myc locus and distributed throughout the endoplasmic and nucleoplasmic reticular network. J Cell Biochem 2008

소아청소년암 장기 생존자의 건강을 위협하는 심독성의 예방에 Dexrazoxane이 효과가 있음을 증명한 연구 Choi HS, Park ES, Kang HJ, Shin HY, Noh CI, Yun YS, Ahn HS, Choi JY. Dexrazoxane for preventing anthracycline cardiotoxicity in children with solid tumors. J Korean Med Sci 2010

철불응성 철결핍빈혈에서 TMPRSS6 유전자 변이에 대한 국내 최초의 보고 Choi HS, Yang HR, Song SH, Seo JY, Lee KO, Kim HJ. A novel mutation Gly603Arg of TMPRSS6 in a Korean female with iron-refractory iron deficiency anemia. Pediatr Blood Cancer 2012

소아 뇌종양과 림프종에서 c-myc 유전자의 상부개방형해석틀 mrtl 및 MycHex1 발현을 최초로 증명한 연구 Ji MH, Kim SK, Kim CY, Phi JH, Jun HJ, Blume SW, Choi HS. Physiological expression and accumulation of the products of two upstream open reading frames mrtl and MycHex1 along with p64 and p67 Myc from the human c-myc locus. J Cell Biochem 2016

소아청소년암 치료기간 중 골밀도 변화에 관한 연구 Choi HS, Chang EJ, Lee EH, Yang HR. Changes in bone health during the first year of cancer treatment in children. J Clin Densitom 2016

Choi HS, Koh SH, Park ES, Kang HJ, Shin HY, Ahn HS. CNS recurrence following CD34+ peripheral blood stem cell transplantation in stage 4 neuroblastoma. Pediatr Blood Cancer. 2005

Koh SH, Choi HS, Park ES, Kang HJ Ahn HS, Shin HY. Co-culture of human CD34+ cells with mesenchymal stem cells increases the survival of CD34+ cells against the 5-aza-deoxycytidine- or trichostatin A-induced cell death. Biochem Biophys Res Commun 2005

Kim EK, Kang HJ, Park JA, Choi HS, Shin HY, Ahn HS. Retrospective analysis of peripheral blood stem cell transplantation for the treatment of high-risk neuroblastoma. J Korean Med Sci 2007

Meng Z, Jackson NL, Choi H, King PH, Emanuel PD, Blume SW. Alterations in RNA-binding activities of IRES-regulatory proteins as a mechanism for physiological variability and pathological dysregulation of IGF-IR translational control in human breast tumor cells. J Cell Physiol 2008

Lee KM, Ward MH, Han S, Ahn HS, Kang HJ, Choi HS, Shin HY, Koo HH, Seo JJ, Choi JE, Ahn YO, Kang D. Paternal smoking, genetic polymorphisms in CYP1A1 and childhood leukemia risk. Leuk Res 2009;

Blume SW, Jackson NL, Frost AR, Grizzle WE, Shcherbakov OD, Choi H, Meng Z. Northwestern profiling of potential translation-regulatory proteins in human breast epithelial cells and malignant breast tissues: evidence for pathological activation of the IGF1R IRES. Exp Mol Pathol 2010;

Meng Z, Jackson NL, Shcherbakov OD, Choi H, Blume SW. The human IGF1R IRES likely operates through a Shine-Dalgarno-like interaction with the G961 loop (E-site) of the 18S rRNA and is kinetically modulated by a naturally-polymorphic polyU loop. J Cell Biochem 2010

Choi HS, Cheong HI, Kim NK, Oh D, Park HW. ADAMTS13 gene mutations in children with hemolytic uremic syndrome. Yonsei Med J 2011

Jung TY, Kim CY, Kim DS, Ra YS, Kim SH, Baek HJ, Choi HS, Kim IA. Prognosis of pediatric high-grade gliomas with temozolomide treatment: a retrospective, multicenter study. Childs Nerv Syst 2012

Choi HS, Song SH, Lee JH, Kim HJ, Yang HR. Serum hepcidin levels and iron parameters in children with iron deficiency. Korean Journal of Hematology 2012

Choi HS, Han JH, Bang JS, Kim IA, Kim CY. A suprasellar cystic germ cell tumor initially diagnosed as an arachnoid cyst. Brain Tumor Res Treat 2013

HR Yang, Yi DY, Choi HS. Comparison between a pediatric health promotion center and a pediatric obesity clinic in detecting metabolic syndrome and non-alcoholic fatty liver disease in children. Journal of Korean Medical Science 2014

Vaklavas C, Meng Z, Choi H, Grizzle WE, Zinn KR, Blume SW. Small molecule inhibitors of IRES-mediated translation. Cancer Biol Ther 2015

저서

2011 혈액학 교과서 제2판
2011 소아청소년암 완치자의 관리

보도자료

분당서울대병원 최형수 교수, 아해 우수연구상 수상
http://health.chosun.com/site/data/html_dir/2016/07/15/2016071502113.html

소아청소년 암환자, 항암치료 후 골밀도 감소…골절 등 위험↑
http://www.donga.com/news/article/all/20160621/78779078/2

소아·청소년 암환자, 성장기에 항암치료 받으면 '골밀도 감소'
https://www.mbn.co.kr/news/society/2923517

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