김인아

  #뇌신경계종양#유방암

학력

1988 이화여자대학교 의학과 졸업
2000 가톨릭의과대학원 방사선종양학과 석사 및 박사
2003 미국 University of Pennsylvania, 박사후 과정

경력

1992 - 1994년 가톨릭의대 치료방사선과 전임의
1995 - 2003년 가톨릭의대 방사선종양학과 교수
2004 - 현재 분당서울대병원 방사선종양학과 교수

논문

Selective inhibition of Ras, Phosphoinositide 3 Kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines. In Ah Kim, Sun Sik Bae, Annemarie Fernandes, Jun Min Wu, Ruth J Muschel, W. Gillies McKenna, Morries J Birnbaum, Eric Bernhard. Cancer Research 2005:65(17): 1:7902-10 (방사선 반응 조절에 중요한 Ras-PI3K-Akt isotype 규명)

HDAC inhibitor-mediated radiosensitization of human cancer cells: Class differences and the potential influence of p53. In Ah Kim, Jin Hee Shin, Il Han Kim et al. Clinical Cancer Research 2006;2(3): 1;12:940-9 (HDAC억제제의 방사선감작기전 및 계층 특이성 규명)

Potential prognostic value of heat-shock protein 90 in the presence of phosphatidylinositol-3-kinase overexpression or loss of PTEN, in invasive breast cancers. Song CH, Park SY, Eom KY, Kim JH, Kim SW, Kim JS, Kim IA. Breast Cancer Research 2010;12(2):R20. (유방암 환자에서 HSP90의 예후인자로서의 가치 규명)

Epigenetic modulation of radiation response in human cancer cells with activated EGFR or HER-2 signaling: Potential role of histone deacetylase 6. In Ah Kim, No M, Lee JM et al. Radiotherapy & Oncology 2009: 92:125-132

Targeting HER2 signaling pathway for radiosensitization: Alternative strategy for therapeutic resistance. No M, Choi EJ, Kim IA. Cancer Biology & Therapy 2009: 8(24):2351-2361

Radiation-induced pulmonary toxicity and related risk factors in breast cancer. Kim HJ, Jang WI, Kim TJ, Kim JH, Kim SW, Kim IA. J Breast Cancer. 2009:12(2):67-72

Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-RAS. Oh JS, Kim JJ, Byun JY, Kim IA. International J of Radiation Oncology, Biology & Physics 2010:76 (1):5-8

HDAC inhibitor-mediated radiosensitization in human carcinoma cells: a general phenomenon? Kim IA, Kim IH, Kim HJ, Chie EK, Kim JS. J Radiat Res 2010;51(3):257-63.

Targeting epidermal growth factor receptor-associated signaling pathways in non-small cell lung cancer cells: implication in radiation response. Choi EJ, Ryu YK, Kim SY, Wu HG, Kim JS, Kim IH, Kim IA. Mol Cancer Res. 2010 Jul;8(7):1027-36

microRNA-7 increases radiosensitivity of human cancer cells with activated EGFR-associated signaling. Lee KM, Choi EJ, Kim IA. Radiotherapy & Oncology 2011:101:171-6

The prognostic value of the nodal ratio in N1 breast cancer. Han TJ, Kang EY, Jeon W, Kim SW, Kim JH, Kim YJ, Park SY, Kim JS, Kim IA. Radiation Oncology 2011 Oct, 6:6;131-137

Pseudoprogression in patients with malignant gliomas treated with concurrent temozolomide and radiotherapy: potential role of p53. Kang HC, Kim CY, Han JH, Choe GY, Kim JH, Kim JH, Kim IA. J Neurooncol. 2011 Mar;13(3):267-79.

Neck control after definitive radiochemotherapy without planned neck dissection in node-positive head and neck cancers. Jang NY, Lee KW, Ahn SH, Kim JS, Kim IA. BMC Cancer 2012 Feb 7;12(1):59

Intensity modulated fractionated stereotactic radiotherapy in high grade gliomas: potential role as an optic nerve & chiasm sparing technique. Koh HG, Kim CY, Choi BS, Kim YJ, Kim JS, and Kim IA. Journal of Radiosurgery and SBRT. 2013:2;307-14

Pseudoprogression and pseudoresponse in the management of high-grade glioma: Optimal decision timing according to the Response Assessment of the Neuro-Oncology Working Group. Chang, JH, Kim CY, Choi BS, Kim YJ, Kim and In Ah Kim, Journal of Korean Neurosurgery. J Korean Neurosurg Soc. 2014 Jan;55(1):5-11.

Prognostic value of the nodal ratio and Ki-67 expression in breast cancer patients treated with postmastectomy radiotherapy. Koo TR, Eom KY, g Kang EY, Kim YJ, Kim SW, Kim JH, Kim JS and Kim IA. Journal of Breast Cancer, J Breast Cancer. 2013 Sep;16(3):274-84.

Sequence-Dependent Radiosensitization of Histone Deacetylase Inhibitors Trichostatin A and SK-7041. Kim JH, Kim IH, Shin JH, Kim HJ, Kim IA. Cancer Res Treat. 2013 Dec;45(4):334-42.

Enhanced cytotoxic effect of radiation and temozolomide in malignant glioma cells: targeting PI3K-AKT-mTOR signaling, HSP90 and histone deacetylases. Choi EJ, Cho BJ, Lee DJ, Hwang YH, Chun SH, Kim HH, Kim IA. BMC Cancer. 2014 Jan 13;14:17.

MicroRNA-21 inhibitor potentiates anti-tumor effect of radiation therapy in vitro and in vivo. Cho BJ, Kim HH, Lee DJ, Choi EJ, Hwang YH, Chun SH, Kim IA. Tumor Microenviron. Ther.2014:1:1-13

Pattern of care of anaplastic oligodendroglioma and oligoastrocytoma in a Korean population: the Korean radiation oncology group study 13-12. Yu T, Kang HC, Lim do H, Kim IH, Chung WK, Suh CO, Choi BO, Cho KH, Cho JH, Kim JH, Park CK, Hong YK, Kim IA. J Neurooncol. 2015;121(3):531-9.

Radiosensitization with combined use of olaparib and PI-103 in triple-negative breast cancer, Jang NY, Kim DH, Cho BJ, Choi EJ, Lee JS, Wu HG, Chie EK, Kim IA. BMC Cancer 2015;15:89

Potential Prognostic Value of Histone Deacetylase 6 and Acetylated Heat-Shock Protein 90 in Early-Stage Breast Cancer. Park YH, Lee KS, Park SY, Kim JH, Kang EY, Kim SW, Eom KY, Kim JS, Kim IA. J Breast Cancer 2015; 18(3): 1-7

A multicenter study of anaplastic oligodendroglioma: the Korean Radiation Oncology Group Study 13-12. Kang HC, Yu T, Lim DH, Kim IH, Chung WK, Suh CO, Choi BO, Cho KH, Cho JH, Kim JH, Nam DH, Park CK, Hong YK, Kim IA. J Neurooncol. 2015;125(1):207-15.

Brain metastasis in human epidermal growth factor receptor 2-positive breast cancer: from biology to treatment. Koo T, Kim IA. Radiat Oncol J. 2016;34(1):1-9.

The Expression of Carbonic Anhydrase (CA) IX/ XII and Lymph Node Metastasis in Early Breast Cancer. Eom KY, Jang MH, Park SY, Kang EY, Kim SW, Kim JH, Kim JS, Kim IA. Cancer Res Treat. 2016;48(1):125-32.

The Effect of Chemoradiotherapy with SRC Tyrosine Kinase Inhibitor, PP2 and Temozolomide on Malignant Glioma Cells in vitro and in vivo. Eom KY, Cho BJ, Choi EJ, Kim JH, Chie EK, Wu HG, Kim IH, Paek SH, Kim JS, Kim IA. Cancer Res Treat 2016;48(2):687-97.

Objective Measurement of Cosmetic Outcomes of Breast Conserving Therapy Using BCCT.core. Yu T, Eom KY, Jang NY, Kim KS, Koo TR, Kwon J, Kim BH, Kang E, Kim SW, Kim JS, Kim IA. Cancer Res Treat. 2016;48(2):491-8.

Isotype-Specific Inhibition of Histone Deacetylases: Identification of Optimal Targets for Radiosensitization. Kim JH, Moon SH, No M, Kim JJ, Choi EJ, Cho BJ, Kim JS, Kim IH, Kim IA. Cancer Res Treat 2016;48(3):1130-40.

MicroRNA-203 Modulates the Radiation Sensitivity of Human Malignant Glioma Cells.Chang JH, Hwang YH, Lee DJ, Kim DH, Park JM, Wu HG, Kim IA. Int J Radiat Oncol Biol Phys. 2016;94(2):412-20.

Inclined head position improves dose distribution during hippocampal-sparing whole brain radiotherapy using VMAT. Kim KS, Seo SJ, Lee J, Seok JY, Hong JW, Chung JB, Kim E, Choi N, Eom KY, Kim IA. Strahlentherapie und Onkologie 2016:192 (7): 473-480.

Inhibition of STAT3 enhances the radiosensitizing effect of temozolomide in glioblastoma cells in vitro and in vivo. Han TJ, Cho BJ, Choi EJ, Kim DH, Song SH, Paek SH, Kim IA. J Neurooncol. 2016;130(1):89-98.

Targeting phosphatidylinositol 4-kinase IIIα for radiosensitization: a potential model of drug repositioning using anti-HCV agent. Kwon J, Kim DH, Park JM, Park YH, Hwang YH, Wu HG, Shin KH, Kim IA. Int J Radiat Oncol Biol Phys. 2016;96:867-876

Radiosensitizing effect of lapatinib in human epidermal growth factor receptor 2-positive breast cancer cells. Yu T, Cho BJ, Choi EJ, Park JM, Kim DH, Kim IA. Oncotarget. 2016;7(48): 79089-79100

Radiotherapy and immune checkpoint blockades: a snapshot in 2016. Koo TR, Kim IA. Radiation Oncology J 2016;34(4);250-259.

Failure patterns according to molecular subtype in patients with invasive breast cancer following postoperative adjuvant radiotherapy: long-term outcomes in contemporary clinical practice. Lim YJ, Lee SW, Choi N, Kwon J, Eom KY, Kang E, Kim EK, Kim SW, Kim JH, Kim YJ, Kim SH, Park SY, Kim JS, Kim IA. Breast Cancer Res Treat. 2017;163(3):555-563.

MicroRNA-200c increases radiosensitivity of human cancer cells with activated EGFR-associated signaling. Koo T, Cho BJ, Kim DH, Park JM, Choi EJ, Kim HH, Lee DJ and Kim IA. Oncotarget, 2017;8;39 65457-65468

A radiosensitivity gene signature and PD-L1 status predict clinical outcome of patients with invasive breast carcinoma in The Cancer Genome Atlas (TCGA) dataset. Jang BS, Kim IA. Radiother Oncol. 2017;1 24:403-407.

Role of radiation therapy in primary central nervous system lymphoma: KROG 14-20 Collaborative Study of Brain and Lymphoma Committee. Koh HK, Kim IH, Kim TM, Lim DH, Oh D, Cho JH, Kim WC, Kim JH, Chung WK, Jeong BK, Kang KM, Hong S, Suh CO, Kim IA. J Neurooncol. 2017 Dec;135(3):629-638.

Inhibition of PI4K IIIα radiosensitizes in human tumor xenograft and immune-competent syngeneic murine tumor model. Park Y, Park JM, Kim DH, Kwon J, Kim IA. Oncotarget. 2017 Nov 30;8(66):110392-110405.

Hippocampus-sparing radiotherapy using volumetric modulated arc therapy (VMAT) to the primary brain tumor: the result of dosimetric study and neurocognitive function assessment. Kim YJ, Kim JS, Kim IA. Radiat Oncol. 2018;13(1):29.

A radiosensitivity gene signature and PD-L1 predict the clinical outcomes of patients with lower grade glioma in TCGA. Jang BS, Kim IA. Radiother Oncol. 2018;128(2):245-253.

Molecular subtype predicts incidence and prognosis of brain metastasis from breast cancer in SEER database. Kim YJ, Kim JS, Kim IA. J Cancer Res Clin Oncol. 2018; 144(9):1803-1816

Prediction of Pseudoprogression versus Progression using Machine Learning Algorithm in Glioblastoma. Jang BS, Jeon SH, Kim IH, Kim IA. Sci Rep. 2018; 8(1):12516

Jeon W, Jang BS, Jeon SH, Kim JH, Kim YJ, Kim SH, Kim CY, Han JH, Kim IA. Analysis of survival outcomes based on molecular subtypes in breast cancer brain metastases: A single institutional cohort. Breast J. 2018;24(6):920-926.

Central Nervous System Failure in Korean Breast Cancer Patients with HER2-Enriched Subtype: Korean Radiation Oncology Group 16-15 Multicenter Retrospective Study. Kim K, Shin KH, Kim JH, Choi DH, Park W, Kim YB, Kim HJ, Kim JH, Park H, Lee SY, Kim J, Oh DH, Kim IA. J Breast Cancer. 2018;22(1):120-130.

Optimal extent of resection for glioblastoma according to site, extension, and size: a population-based study in the temozolomide era. Kim YJ, Lee DJ, Park CK, Kim IA. Neurosurg Rev. 2019 :42(4);937-950

Survival outcomes of breast cancer patients with brain metastases: A multicenter retrospective study in Korea (KROG 16-12). Kim JS, Kim K, Jung W, Shin KH, Im SA, Kim HJ, Kim YB. Kim IA. Breast. 2019;49:41-47.

Tumor mutation burden, immune checkpoint crosstalk and radiosensitivity in single-cell RNA sequencing data of breast cancer. Jang BS, Han W, Kim IA. Radiother Oncol. 2019 Nov 22. pii: S0167-8140(19)33469-3.

A Radiosensitivity Gene Signature and PD-L1 Status Predict Clinical Outcome of Patients with Glioblastoma Multiforme in The Cancer Genome Atlas Dataset. Jang BS, Kim IA. Cancer Res Treat. 2019 Nov 20. doi: 10.4143/crt.2019.440.

저서

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보도자료

대한방사선종양학회 정기학술대회 주요 수상자
http://medicalworldnews.co.kr/news/view.php?idx=1510927771

포스팅

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영상자료

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발표자료

Targeting HER-2 Signaling Network: Implication in Radiation Response: In “Breast Cancer - Carcinogenesis, Cell growth and Signaling pathway” ISBN 978-953-307-714-7 Modulation of radiation response using microRNAs (#10-2013-0002239)

Modulation of radiation response using microRNAs. Korea (#10-2013-0002239) and USA (#13/888624)

Targeting PI4K for Radiosensitization. Korea (#10-2015-0056653) and USA (#15/048,872)